EXPLORING PREVALENCE, ANTIMICROBIAL SUSCEPTIBILITY, VIRULENCE PROFILES, AND MULTIDRUG RESISTANCE IN STAPHYLOCOCCUS AUREUS ISOLATES FROM RESPIRATORY DISEASE-AFFECTED SHEEP AND GOATS REARED BY THE MIGRATORY COMMUNITIES OF LOWER HIMALAYAS
Staphylococcus aureus is a significant bacterium that causes substantial economic losses in the livestock sector and poses life-threatening risks to both humans and animals. This study aimed to explore the prevalence, susceptibility to antimicrobials, and profiles of virulence and antimicrobial re...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
West Bengal Veterinary Alumni Association
2024-12-01
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| Series: | Exploratory Animal and Medical Research |
| Subjects: | |
| Online Access: | https://animalmedicalresearch.org/Vol.14_Issue-2_December_2024/EXPLORING%20PREVALENCE,%20ANTIMICROBIAL%20SUSCEPTIBILITY,%20VIRULENCE.pdf |
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| Summary: | Staphylococcus aureus is a significant bacterium that causes substantial economic losses in the
livestock sector and poses life-threatening risks to both humans and animals. This study aimed to explore
the prevalence, susceptibility to antimicrobials, and profiles of virulence and antimicrobial resistance
(AMR) genes in S. aureus isolated from nasal swabs and lung tissues of sheep and goats exhibiting symptoms
of respiratory disease. A total of 194 samples were examined, resulting in the isolation and confirmation of S.
aureus in 65 samples, indicating an overall prevalence of 33.5%. These isolates were further subjected to an
AMR assay. Among the representative isolates (37), sensitivity was observed to chloramphenicol and
ceftriaxone. Conversely, penicillin showed the lowest efficacy, with 83.8% of isolates demonstrating
resistance, followed closely by amoxiclav, which exhibited resistance in 75.7% of isolates. Close to threequarters of isolates carried at least one AMR gene. Virulence genes were identified in 67.6% of S. aureus
isolates, with coa and lukpv detected in 37.8% and arcA in 32.4% of isolates. Additionally, mecA and vatC
were present in 54.05%, vatB in 43.25% and aphD in 18.91% of S. aureus isolates. A substantial 91.9% of
isolates exhibited multidrug resistance, and MAR indices exceeding 0.2 were recorded in 86.5% of S. aureus
isolates, indicating a high public health risk. These findings underscore the importance of prioritizing
infections caused by S. aureus, necessitating heightened attention from both veterinarians and healthcare
workers in migratory communities. Furthermore, the regulated and judicious use of antimicrobials is
crucial to mitigate the risks associated with antimicrobial resistance in these settings. |
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| ISSN: | 2277-470X 2319-247X |