Detection of Amisulpride Using a Chromium-Salophen Optical Probe
Patients with psychosis around the world are routinely prescribed anti-psychotic medications. Amisulpride (AMI) is one such medication. In order to detect cases like drug overdose, drug abuse, or intentional poisoning, simple, selective and sensitive probes are required. In the present work, we have...
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| Format: | Article |
| Language: | Arabic |
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Naif University Publishing House
2024-07-01
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| Series: | Arab Journal of Forensic Sciences & Forensic Medicine |
| Subjects: | |
| Online Access: | https://journals.nauss.edu.sa/index.php/AJFSFM/article/view/2990 |
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| author | Namrata Dhadnekar Kapil Kumar Devanshi Bhatt Himali Upadhyay Shibu Pillai Uma Harikrishnan |
| author_facet | Namrata Dhadnekar Kapil Kumar Devanshi Bhatt Himali Upadhyay Shibu Pillai Uma Harikrishnan |
| author_sort | Namrata Dhadnekar |
| collection | DOAJ |
| description | Patients with psychosis around the world are routinely prescribed anti-psychotic medications. Amisulpride (AMI) is one such medication. In order to detect cases like drug overdose, drug abuse, or intentional poisoning, simple, selective and sensitive probes are required. In the present work, we have synthesized a fluorescent probe (CRSA) for detecting Amisulpride (AMI) and characterized it by FT-IR, NMR and mass spectroscopy. The probe emits green light in ethanol and acts as a “turn-off” luminescent sensor for the anti-psychotic drug Amisulpride (AMI) with a quenching percentage of 94% and an excellent limit of detection of 1.6 μM. The sensor responded effectively to only AMI even in the presence of other drugs like sertraline, fluoxetine, escitalopram, paroxetine, olanzapine and clozapine ensuring good selectivity and specificity of the method. The effect of pH on the sensing abilities CRSA and the applicability of the method to real-life samples were also studied using spiked alcohol samples. |
| format | Article |
| id | doaj-art-4bc7e38e6ec24dd4a203fddd99423bcd |
| institution | DOAJ |
| issn | 1658-6786 1658-6794 |
| language | Arabic |
| publishDate | 2024-07-01 |
| publisher | Naif University Publishing House |
| record_format | Article |
| series | Arab Journal of Forensic Sciences & Forensic Medicine |
| spelling | doaj-art-4bc7e38e6ec24dd4a203fddd99423bcd2025-08-20T02:56:21ZaraNaif University Publishing HouseArab Journal of Forensic Sciences & Forensic Medicine1658-67861658-67942024-07-016Special Issue15516410.26735/TZYP38602694Detection of Amisulpride Using a Chromium-Salophen Optical ProbeNamrata Dhadnekar0Kapil Kumar1Devanshi Bhatt2Himali Upadhyay3Shibu Pillai4Uma Harikrishnan5Department of Biochemistry and Forensic Science, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, IndiaDepartment of Biochemistry and Forensic Science, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, IndiaDepartment of Biochemistry and Forensic Science, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, IndiaDepartment of Biochemistry and Forensic Science, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, IndiaChemical Engineering Department, Nirma University, Ahmedabad, IndiaDepartment of Chemistry, St. Xavier’s College, Navrangpura, Ahmedabad, IndiaPatients with psychosis around the world are routinely prescribed anti-psychotic medications. Amisulpride (AMI) is one such medication. In order to detect cases like drug overdose, drug abuse, or intentional poisoning, simple, selective and sensitive probes are required. In the present work, we have synthesized a fluorescent probe (CRSA) for detecting Amisulpride (AMI) and characterized it by FT-IR, NMR and mass spectroscopy. The probe emits green light in ethanol and acts as a “turn-off” luminescent sensor for the anti-psychotic drug Amisulpride (AMI) with a quenching percentage of 94% and an excellent limit of detection of 1.6 μM. The sensor responded effectively to only AMI even in the presence of other drugs like sertraline, fluoxetine, escitalopram, paroxetine, olanzapine and clozapine ensuring good selectivity and specificity of the method. The effect of pH on the sensing abilities CRSA and the applicability of the method to real-life samples were also studied using spiked alcohol samples.https://journals.nauss.edu.sa/index.php/AJFSFM/article/view/2990forensic scienceamisulprideschiff basedrug detectionfluorescence analysis methoddrug overdose |
| spellingShingle | Namrata Dhadnekar Kapil Kumar Devanshi Bhatt Himali Upadhyay Shibu Pillai Uma Harikrishnan Detection of Amisulpride Using a Chromium-Salophen Optical Probe Arab Journal of Forensic Sciences & Forensic Medicine forensic science amisulpride schiff base drug detection fluorescence analysis method drug overdose |
| title | Detection of Amisulpride Using a Chromium-Salophen Optical Probe |
| title_full | Detection of Amisulpride Using a Chromium-Salophen Optical Probe |
| title_fullStr | Detection of Amisulpride Using a Chromium-Salophen Optical Probe |
| title_full_unstemmed | Detection of Amisulpride Using a Chromium-Salophen Optical Probe |
| title_short | Detection of Amisulpride Using a Chromium-Salophen Optical Probe |
| title_sort | detection of amisulpride using a chromium salophen optical probe |
| topic | forensic science amisulpride schiff base drug detection fluorescence analysis method drug overdose |
| url | https://journals.nauss.edu.sa/index.php/AJFSFM/article/view/2990 |
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