Pharmacotherapy of anxiety disorders in the 21st century: A call for novel approaches

While limited advances have occurred in the past 30 years in the pharmacological management of anxiety and stress-related disorders, novel molecular pathways both within and without the monoamine systems are currently under investigation and offer promising new avenues for more effective future trea...

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Main Authors: Eric Bui, Franklin King, Andrew Melaragno
Format: Article
Language:English
Published: BMJ Publishing Group 2019-12-01
Series:General Psychiatry
Online Access:https://gpsych.bmj.com/content/32/6/e100136.full
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author Eric Bui
Franklin King
Andrew Melaragno
author_facet Eric Bui
Franklin King
Andrew Melaragno
author_sort Eric Bui
collection DOAJ
description While limited advances have occurred in the past 30 years in the pharmacological management of anxiety and stress-related disorders, novel molecular pathways both within and without the monoamine systems are currently under investigation and offer promising new avenues for more effective future treatments. Enhancing psychotherapy approaches with pharmacological compounds offers the potential to not only transform the standard of care of these conditions, but more broadly would introduce a paradigm shift in the way medications and their role in psychiatric care are conceptualised. Although further human trials and more translational research are sorely needed, continuing to pursue innovative mechanisms and treatments is hoped to yield substantial results in the coming decades and a departure from the reliance on chemical agents of the 20th century.
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series General Psychiatry
spelling doaj-art-4bc7795e0d964a779637219cd7cb83a12025-08-20T02:12:46ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2019-12-0132610.1136/gpsych-2019-100136Pharmacotherapy of anxiety disorders in the 21st century: A call for novel approachesEric Bui0Franklin King1Andrew Melaragno2Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USADepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USADepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USAWhile limited advances have occurred in the past 30 years in the pharmacological management of anxiety and stress-related disorders, novel molecular pathways both within and without the monoamine systems are currently under investigation and offer promising new avenues for more effective future treatments. Enhancing psychotherapy approaches with pharmacological compounds offers the potential to not only transform the standard of care of these conditions, but more broadly would introduce a paradigm shift in the way medications and their role in psychiatric care are conceptualised. Although further human trials and more translational research are sorely needed, continuing to pursue innovative mechanisms and treatments is hoped to yield substantial results in the coming decades and a departure from the reliance on chemical agents of the 20th century.https://gpsych.bmj.com/content/32/6/e100136.full
spellingShingle Eric Bui
Franklin King
Andrew Melaragno
Pharmacotherapy of anxiety disorders in the 21st century: A call for novel approaches
General Psychiatry
title Pharmacotherapy of anxiety disorders in the 21st century: A call for novel approaches
title_full Pharmacotherapy of anxiety disorders in the 21st century: A call for novel approaches
title_fullStr Pharmacotherapy of anxiety disorders in the 21st century: A call for novel approaches
title_full_unstemmed Pharmacotherapy of anxiety disorders in the 21st century: A call for novel approaches
title_short Pharmacotherapy of anxiety disorders in the 21st century: A call for novel approaches
title_sort pharmacotherapy of anxiety disorders in the 21st century a call for novel approaches
url https://gpsych.bmj.com/content/32/6/e100136.full
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