Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway

Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway

Abstract Background Gut microbiota has emerged as a promising therapeutic target for neurodegenerative disorders through regulation of neuroinflammatory responses, while its role in optic nerve degeneration remains incompletely characterized. This study elucidates the neuroprotective role of gut mic...

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Main Authors: Ning Wang, Chengyang Sun, Yijie Yang, Dandan Zhang, Lulu Huang, Chenrui Xu, Minghan Wang, Mengmeng Xu, Tongtong Yan, Yue Wu, Li Xu, Yahan Ju, Hao Sun, Wenyi Guo
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Neuroinflammation
Subjects:
Gut microbiota-eye axis
Glaucoma
Neuroinflammation
Tryptophan metabolites
AhR
Microglia
Online Access:https://doi.org/10.1186/s12974-025-03505-4
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https://doi.org/10.1186/s12974-025-03505-4

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