Exploring adjunctive continuous theta burst stimulation for treatment-resistant auditory hallucinations in schizophrenia: Insights from a case series
Background: Auditory hallucinations affect 60%–80% of schizophrenia patients, often causing distress and functional impairment. Despite antipsychotic treatment, 30% remain resistant. Dysfunctional prefrontal-temporal connectivity has been found to be associated with these symptoms. Repetitive Transc...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_200_25 |
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| author | Sukriti Mukherjee Jayashree Kalita Trishita Chatterjee Zinedine Zidane Sukanto Sarkar |
| author_facet | Sukriti Mukherjee Jayashree Kalita Trishita Chatterjee Zinedine Zidane Sukanto Sarkar |
| author_sort | Sukriti Mukherjee |
| collection | DOAJ |
| description | Background:
Auditory hallucinations affect 60%–80% of schizophrenia patients, often causing distress and functional impairment. Despite antipsychotic treatment, 30% remain resistant. Dysfunctional prefrontal-temporal connectivity has been found to be associated with these symptoms. Repetitive Transcranial Magnetic Stimulation (rTMS) is a neuromodulation technique that targets the dysfunctional area and is being used for treatment of persistent auditory hallucinations in Schizophrenia with mixed results. Continuous Theta Burst Stimulation (cTBS) is a novel neuromodulation technique that works on the principals of rTMS with similar or more robust clinical efficacy.
Cases:
We describe the cases of three patients where cTBS was applied.
Conclusion:
Significant improvement in auditory hallucinations was noticed in all three patients. While this evidence must be interpreted with caution, future studies on this topic with robust protocol to be conducted. |
| format | Article |
| id | doaj-art-4bc1e58fee8147ceaff12e2edf9d03c3 |
| institution | Kabale University |
| issn | 0019-5545 1998-3794 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Psychiatry |
| spelling | doaj-art-4bc1e58fee8147ceaff12e2edf9d03c32025-08-20T03:29:45ZengWolters Kluwer Medknow PublicationsIndian Journal of Psychiatry0019-55451998-37942025-06-0167662763010.4103/indianjpsychiatry.indianjpsychiatry_200_25Exploring adjunctive continuous theta burst stimulation for treatment-resistant auditory hallucinations in schizophrenia: Insights from a case seriesSukriti MukherjeeJayashree KalitaTrishita ChatterjeeZinedine ZidaneSukanto SarkarBackground: Auditory hallucinations affect 60%–80% of schizophrenia patients, often causing distress and functional impairment. Despite antipsychotic treatment, 30% remain resistant. Dysfunctional prefrontal-temporal connectivity has been found to be associated with these symptoms. Repetitive Transcranial Magnetic Stimulation (rTMS) is a neuromodulation technique that targets the dysfunctional area and is being used for treatment of persistent auditory hallucinations in Schizophrenia with mixed results. Continuous Theta Burst Stimulation (cTBS) is a novel neuromodulation technique that works on the principals of rTMS with similar or more robust clinical efficacy. Cases: We describe the cases of three patients where cTBS was applied. Conclusion: Significant improvement in auditory hallucinations was noticed in all three patients. While this evidence must be interpreted with caution, future studies on this topic with robust protocol to be conducted.https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_200_25clozapine resistant schizophreniacontinuous theta burst stimulationneuromodulationpersistent auditory hallucinations |
| spellingShingle | Sukriti Mukherjee Jayashree Kalita Trishita Chatterjee Zinedine Zidane Sukanto Sarkar Exploring adjunctive continuous theta burst stimulation for treatment-resistant auditory hallucinations in schizophrenia: Insights from a case series Indian Journal of Psychiatry clozapine resistant schizophrenia continuous theta burst stimulation neuromodulation persistent auditory hallucinations |
| title | Exploring adjunctive continuous theta burst stimulation for treatment-resistant auditory hallucinations in schizophrenia: Insights from a case series |
| title_full | Exploring adjunctive continuous theta burst stimulation for treatment-resistant auditory hallucinations in schizophrenia: Insights from a case series |
| title_fullStr | Exploring adjunctive continuous theta burst stimulation for treatment-resistant auditory hallucinations in schizophrenia: Insights from a case series |
| title_full_unstemmed | Exploring adjunctive continuous theta burst stimulation for treatment-resistant auditory hallucinations in schizophrenia: Insights from a case series |
| title_short | Exploring adjunctive continuous theta burst stimulation for treatment-resistant auditory hallucinations in schizophrenia: Insights from a case series |
| title_sort | exploring adjunctive continuous theta burst stimulation for treatment resistant auditory hallucinations in schizophrenia insights from a case series |
| topic | clozapine resistant schizophrenia continuous theta burst stimulation neuromodulation persistent auditory hallucinations |
| url | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_200_25 |
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