Exploring adjunctive continuous theta burst stimulation for treatment-resistant auditory hallucinations in schizophrenia: Insights from a case series
Background: Auditory hallucinations affect 60%–80% of schizophrenia patients, often causing distress and functional impairment. Despite antipsychotic treatment, 30% remain resistant. Dysfunctional prefrontal-temporal connectivity has been found to be associated with these symptoms. Repetitive Transc...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_200_25 |
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| Summary: | Background:
Auditory hallucinations affect 60%–80% of schizophrenia patients, often causing distress and functional impairment. Despite antipsychotic treatment, 30% remain resistant. Dysfunctional prefrontal-temporal connectivity has been found to be associated with these symptoms. Repetitive Transcranial Magnetic Stimulation (rTMS) is a neuromodulation technique that targets the dysfunctional area and is being used for treatment of persistent auditory hallucinations in Schizophrenia with mixed results. Continuous Theta Burst Stimulation (cTBS) is a novel neuromodulation technique that works on the principals of rTMS with similar or more robust clinical efficacy.
Cases:
We describe the cases of three patients where cTBS was applied.
Conclusion:
Significant improvement in auditory hallucinations was noticed in all three patients. While this evidence must be interpreted with caution, future studies on this topic with robust protocol to be conducted. |
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| ISSN: | 0019-5545 1998-3794 |