Potential implications of thyroid autoantibodies in children, adolescents, and young adults with thyroid nodules in Japan: The Fukushima Health Management Survey

There have been no systematic epidemiological evaluations of the relationship between thyroid autoimmunity and the clinical background of young patients with thyroid nodules. We aimed to clarify the clinical features associated with thyroglobulin or thyroperoxidase antibodies (thyroid autoantibodies...

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Main Authors: Rina Tazaki, Yurie Kobashi, Nana Nakahata, Mahiro Asano, Norikazu Abe, Haruka Ejiri, Ayako Sato, Natsuki Nagamine, Chisato Takahashi, Yukie Yamaya, Manabu Iwadate, Takashi Matsuzuka, Satoshi Suzuki, Tetsuya Ohira, Satoru Suzuki, Fumihiko Furuya, Hiroki Shimura, Shinichi Suzuki, Susumu Yokoya, Shunichi Yamashita, Hitoshi Ohto, Seiji Yasumura
Format: Article
Language:English
Published: The Japan Endocrine Society 2024-12-01
Series:Endocrine Journal
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Online Access:https://www.jstage.jst.go.jp/article/endocrj/71/12/71_EJ24-0293/_html/-char/en
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author Rina Tazaki
Yurie Kobashi
Nana Nakahata
Mahiro Asano
Norikazu Abe
Haruka Ejiri
Ayako Sato
Natsuki Nagamine
Chisato Takahashi
Yukie Yamaya
Manabu Iwadate
Takashi Matsuzuka
Satoshi Suzuki
Tetsuya Ohira
Satoru Suzuki
Fumihiko Furuya
Hiroki Shimura
Shinichi Suzuki
Susumu Yokoya
Shunichi Yamashita
Hitoshi Ohto
Seiji Yasumura
author_facet Rina Tazaki
Yurie Kobashi
Nana Nakahata
Mahiro Asano
Norikazu Abe
Haruka Ejiri
Ayako Sato
Natsuki Nagamine
Chisato Takahashi
Yukie Yamaya
Manabu Iwadate
Takashi Matsuzuka
Satoshi Suzuki
Tetsuya Ohira
Satoru Suzuki
Fumihiko Furuya
Hiroki Shimura
Shinichi Suzuki
Susumu Yokoya
Shunichi Yamashita
Hitoshi Ohto
Seiji Yasumura
author_sort Rina Tazaki
collection DOAJ
description There have been no systematic epidemiological evaluations of the relationship between thyroid autoimmunity and the clinical background of young patients with thyroid nodules. We aimed to clarify the clinical features associated with thyroglobulin or thyroperoxidase antibodies (thyroid autoantibodies [Tabs]) in children and young adults with nodules. We performed a cross-sectional study using data from 3,018 participants of 3–29 years of age with nodules, including thyroid cancer, from the Fukushima Health Management Survey. After stratification of the data for body mass index (BMI) and the bilateral width and thickness of the area (BWTAR) as indicators of thyroid volume for age, sex, body surface area (BSA), and sex-adjusted standard deviation score (SDS), trend analyses were performed. A logistic regression analysis was performed using tab-positivity as an objective variable. The overall prevalence of tab-positivity is 13.9%. It was high in females (17%), participants with diffuse goiter (DG) (19.2%), and those with papillary thyroid carcinoma (PTC) (12.8%). The age- and sex-adjusted odds ratios (95% confidence intervals) for BMI-SDS, BWTAR-SDS, presence of DG, diagnosis of PTC, and TSH concentrations were 0.962 (0.863–1.073), 1.263 (1.171–1.361), 7.357 (4.816–11.239), 2.787 (1.965–4.014), and 1.403 (1.257–1.564), respectively. Tab positivity was independently associated with a large thyroid, the presence of DG, the presence of PTC, and a high TSH concentration in patients with nodules. Based on the systematic epidemiologic evidence shown in young patients, Tab positivity might complement ultrasonography for the assessment of the thyroid function and identification of malignancy in younger patients with asymptomatic thyroid nodules.
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publisher The Japan Endocrine Society
record_format Article
series Endocrine Journal
spelling doaj-art-4bb989f28ff541a1af571bf5b3e8130a2025-01-22T05:34:07ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-12-0171121145115510.1507/endocrj.EJ24-0293endocrjPotential implications of thyroid autoantibodies in children, adolescents, and young adults with thyroid nodules in Japan: The Fukushima Health Management SurveyRina Tazaki0Yurie Kobashi1Nana Nakahata2Mahiro Asano3Norikazu Abe4Haruka Ejiri5Ayako Sato6Natsuki Nagamine7Chisato Takahashi8Yukie Yamaya9Manabu Iwadate10Takashi Matsuzuka11Satoshi Suzuki12Tetsuya Ohira13Satoru Suzuki14Fumihiko Furuya15Hiroki Shimura16Shinichi Suzuki17Susumu Yokoya18Shunichi Yamashita19Hitoshi Ohto20Seiji Yasumura21Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanDepartment of Surgery, Minamisoma Municipal General Hospital, Fukushima 975-0033, JapanDepartment of Head and Neck Surgery and Otolaryngology, Asahi University Hospital, Gifu 550-8523, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanNihonmatsu Hospital, Fukushima 964-0871, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanRadiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960-1295, JapanThere have been no systematic epidemiological evaluations of the relationship between thyroid autoimmunity and the clinical background of young patients with thyroid nodules. We aimed to clarify the clinical features associated with thyroglobulin or thyroperoxidase antibodies (thyroid autoantibodies [Tabs]) in children and young adults with nodules. We performed a cross-sectional study using data from 3,018 participants of 3–29 years of age with nodules, including thyroid cancer, from the Fukushima Health Management Survey. After stratification of the data for body mass index (BMI) and the bilateral width and thickness of the area (BWTAR) as indicators of thyroid volume for age, sex, body surface area (BSA), and sex-adjusted standard deviation score (SDS), trend analyses were performed. A logistic regression analysis was performed using tab-positivity as an objective variable. The overall prevalence of tab-positivity is 13.9%. It was high in females (17%), participants with diffuse goiter (DG) (19.2%), and those with papillary thyroid carcinoma (PTC) (12.8%). The age- and sex-adjusted odds ratios (95% confidence intervals) for BMI-SDS, BWTAR-SDS, presence of DG, diagnosis of PTC, and TSH concentrations were 0.962 (0.863–1.073), 1.263 (1.171–1.361), 7.357 (4.816–11.239), 2.787 (1.965–4.014), and 1.403 (1.257–1.564), respectively. Tab positivity was independently associated with a large thyroid, the presence of DG, the presence of PTC, and a high TSH concentration in patients with nodules. Based on the systematic epidemiologic evidence shown in young patients, Tab positivity might complement ultrasonography for the assessment of the thyroid function and identification of malignancy in younger patients with asymptomatic thyroid nodules.https://www.jstage.jst.go.jp/article/endocrj/71/12/71_EJ24-0293/_html/-char/enautoimmunityhashimoto’s thyroiditischildultrasonographyhealth survey
spellingShingle Rina Tazaki
Yurie Kobashi
Nana Nakahata
Mahiro Asano
Norikazu Abe
Haruka Ejiri
Ayako Sato
Natsuki Nagamine
Chisato Takahashi
Yukie Yamaya
Manabu Iwadate
Takashi Matsuzuka
Satoshi Suzuki
Tetsuya Ohira
Satoru Suzuki
Fumihiko Furuya
Hiroki Shimura
Shinichi Suzuki
Susumu Yokoya
Shunichi Yamashita
Hitoshi Ohto
Seiji Yasumura
Potential implications of thyroid autoantibodies in children, adolescents, and young adults with thyroid nodules in Japan: The Fukushima Health Management Survey
Endocrine Journal
autoimmunity
hashimoto’s thyroiditis
child
ultrasonography
health survey
title Potential implications of thyroid autoantibodies in children, adolescents, and young adults with thyroid nodules in Japan: The Fukushima Health Management Survey
title_full Potential implications of thyroid autoantibodies in children, adolescents, and young adults with thyroid nodules in Japan: The Fukushima Health Management Survey
title_fullStr Potential implications of thyroid autoantibodies in children, adolescents, and young adults with thyroid nodules in Japan: The Fukushima Health Management Survey
title_full_unstemmed Potential implications of thyroid autoantibodies in children, adolescents, and young adults with thyroid nodules in Japan: The Fukushima Health Management Survey
title_short Potential implications of thyroid autoantibodies in children, adolescents, and young adults with thyroid nodules in Japan: The Fukushima Health Management Survey
title_sort potential implications of thyroid autoantibodies in children adolescents and young adults with thyroid nodules in japan the fukushima health management survey
topic autoimmunity
hashimoto’s thyroiditis
child
ultrasonography
health survey
url https://www.jstage.jst.go.jp/article/endocrj/71/12/71_EJ24-0293/_html/-char/en
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