HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification

HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification

Abstract Background Hepatocellular carcinoma is a fatal malignancy that lacking specific therapies. Homeobox B4 (HOXB4) was negatively correlated with poor prognosis in cancers, but its role in hepatocellular carcinoma has not been elucidated. Results We confirmed that HOXB4 was downregulated in hep...

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Bibliographic Details
Main Authors: Enshuang Guo, Lei Li, Jiankun Yang, Yongjian Zhou, Lu Bai, Weiwei Zhu, Qiuyue Hu, Huifen Wang, Hongqiang Liu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Biology Direct
Subjects:
Hepatocellular carcinoma
Homeobox B4
Methyltransferase-like 7B
Malignant progression
Immune evasion
Online Access:https://doi.org/10.1186/s13062-025-00620-3
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