Highly Pathogenic Avian Influenza A(H5N1) in Animals: A Systematic Review and Meta-Analysis
Introduction: Avian influenza A H5N1 is a significant global public health threat. Although relevant, systematic reviews about its prevalence in animals are lacking. Methods: We performed a systematic literature review in bibliographic databases to assess the prevalence of H5N1 in animals. A meta-an...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224006908 |
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| author | Dr D. Katterine Bonilla-Aldana Dr Dayana M Calle-Hernández Dr Juan R Ulloque-Badaracco Dr Esteban A Alarcón-Braga Dr Enrique A Hernández-Bustamante Dr Juan C Cabrera-Guzmán Dr Sthephanie M Quispe-Vasquez Dr Miguel A Huayta-Cortez Dr Vicente A Benites-Zapata Dr Alfonso J Rodriguez-Morales |
| author_facet | Dr D. Katterine Bonilla-Aldana Dr Dayana M Calle-Hernández Dr Juan R Ulloque-Badaracco Dr Esteban A Alarcón-Braga Dr Enrique A Hernández-Bustamante Dr Juan C Cabrera-Guzmán Dr Sthephanie M Quispe-Vasquez Dr Miguel A Huayta-Cortez Dr Vicente A Benites-Zapata Dr Alfonso J Rodriguez-Morales |
| author_sort | Dr D. Katterine Bonilla-Aldana |
| collection | DOAJ |
| description | Introduction: Avian influenza A H5N1 is a significant global public health threat. Although relevant, systematic reviews about its prevalence in animals are lacking. Methods: We performed a systematic literature review in bibliographic databases to assess the prevalence of H5N1 in animals. A meta-analysis with a random-effects model was performed to calculate the pooled prevalence and 95% confidence intervals (95%CI). In addition, measures of heterogeneity (Cochran's Q statistic and I2 test) were reported. Results: The literature search yielded 1357 articles, of which 33 studies were fully valid for analysis, including 96,909 animals. The pooled prevalence for H5N1 in birds (n=90,045, 234 studies) was 5.0% (95%CI: 4.0-6.0%; I2=99.21); in pigs (n=3,178, 4 studies) was 1.0% (95%CI: 0.0-1.0%); in cats (n=2,911, 4 studies) was 0.0% (95%CI: 0.0-1.0%); and in dogs (n=479, 3 studies) was 0.0% (95%CI: 0.0-2.0%). Conclusions: While the occurrence of H5N1 in animals might be comparatively limited compared to other influenza viruses, its impact on public health can be substantial when it transmits to humans. This virus can potentially induce severe illness and has been linked to previous outbreaks. Therefore, it is essential to closely monitor and comprehend the factors influencing the prevalence of H5N1 in both avian and human populations to develop effective disease control and prevention strategies. |
| format | Article |
| id | doaj-art-4bb7a48eadfd43d2a4290089c5f3a0ff |
| institution | OA Journals |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-4bb7a48eadfd43d2a4290089c5f3a0ff2025-08-20T02:00:46ZengElsevierInternational Journal of Infectious Diseases1201-97122025-03-0115210761510.1016/j.ijid.2024.107615Highly Pathogenic Avian Influenza A(H5N1) in Animals: A Systematic Review and Meta-AnalysisDr D. Katterine Bonilla-Aldana0Dr Dayana M Calle-Hernández1Dr Juan R Ulloque-Badaracco2Dr Esteban A Alarcón-Braga3Dr Enrique A Hernández-Bustamante4Dr Juan C Cabrera-Guzmán5Dr Sthephanie M Quispe-Vasquez6Dr Miguel A Huayta-Cortez7Dr Vicente A Benites-Zapata8Dr Alfonso J Rodriguez-Morales9Research Unit, Universidad ContinentalBioparque UkumaríFacultad de Ciencias de la Salud, Universidad Peruana de Ciencias AplicadasFacultad de Ciencias de la Salud, Universidad Peruana de Ciencias AplicadasGrupo Peruano de Investigación Epidemiológica, Unidad para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de LoyolaFacultad de Ciencias de la Salud, Universidad Peruana de Ciencias AplicadasFacultad de Ciencias de la Salud, Universidad Peruana de Ciencias AplicadasFacultad de Ciencias de la Salud, Universidad Peruana de Ciencias AplicadasGrupo Peruano de Investigación Epidemiológica, Unidad para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de LoyolaFaculty of Health Sciences, Universidad Cientifica del Sur; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American UniversityIntroduction: Avian influenza A H5N1 is a significant global public health threat. Although relevant, systematic reviews about its prevalence in animals are lacking. Methods: We performed a systematic literature review in bibliographic databases to assess the prevalence of H5N1 in animals. A meta-analysis with a random-effects model was performed to calculate the pooled prevalence and 95% confidence intervals (95%CI). In addition, measures of heterogeneity (Cochran's Q statistic and I2 test) were reported. Results: The literature search yielded 1357 articles, of which 33 studies were fully valid for analysis, including 96,909 animals. The pooled prevalence for H5N1 in birds (n=90,045, 234 studies) was 5.0% (95%CI: 4.0-6.0%; I2=99.21); in pigs (n=3,178, 4 studies) was 1.0% (95%CI: 0.0-1.0%); in cats (n=2,911, 4 studies) was 0.0% (95%CI: 0.0-1.0%); and in dogs (n=479, 3 studies) was 0.0% (95%CI: 0.0-2.0%). Conclusions: While the occurrence of H5N1 in animals might be comparatively limited compared to other influenza viruses, its impact on public health can be substantial when it transmits to humans. This virus can potentially induce severe illness and has been linked to previous outbreaks. Therefore, it is essential to closely monitor and comprehend the factors influencing the prevalence of H5N1 in both avian and human populations to develop effective disease control and prevention strategies.http://www.sciencedirect.com/science/article/pii/S1201971224006908 |
| spellingShingle | Dr D. Katterine Bonilla-Aldana Dr Dayana M Calle-Hernández Dr Juan R Ulloque-Badaracco Dr Esteban A Alarcón-Braga Dr Enrique A Hernández-Bustamante Dr Juan C Cabrera-Guzmán Dr Sthephanie M Quispe-Vasquez Dr Miguel A Huayta-Cortez Dr Vicente A Benites-Zapata Dr Alfonso J Rodriguez-Morales Highly Pathogenic Avian Influenza A(H5N1) in Animals: A Systematic Review and Meta-Analysis International Journal of Infectious Diseases |
| title | Highly Pathogenic Avian Influenza A(H5N1) in Animals: A Systematic Review and Meta-Analysis |
| title_full | Highly Pathogenic Avian Influenza A(H5N1) in Animals: A Systematic Review and Meta-Analysis |
| title_fullStr | Highly Pathogenic Avian Influenza A(H5N1) in Animals: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Highly Pathogenic Avian Influenza A(H5N1) in Animals: A Systematic Review and Meta-Analysis |
| title_short | Highly Pathogenic Avian Influenza A(H5N1) in Animals: A Systematic Review and Meta-Analysis |
| title_sort | highly pathogenic avian influenza a h5n1 in animals a systematic review and meta analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224006908 |
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