The Effect of High Poly Unsaturated Fatty Acid (PUFA) Dietary Supplementation on Inflammatory Status of Patients with Advanced Cervical Cancer on Radiation Treatment
Aim: to identify the effect of high-PUFA dietary supplementation on inflammatory status of patients with advanced cervical cancer. Methods: a randomized double-blind clinical trial was conducted in patients with advanced cervical cancer who had undergone external radiation therapy at Department of R...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Interna Publishing
2016-05-01
|
| Series: | Acta Medica Indonesiana |
| Online Access: | http://actamedindones.org/index.php/ijim/article/view/8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849391573885779968 |
|---|---|
| author | Sri Wuryanti Andrijono Andrijono Susworo Susworo Fiastuti Witjaksono |
| author_facet | Sri Wuryanti Andrijono Andrijono Susworo Susworo Fiastuti Witjaksono |
| author_sort | Sri Wuryanti |
| collection | DOAJ |
| description | Aim: to identify the effect of high-PUFA dietary supplementation on inflammatory status of patients with advanced cervical cancer. Methods: a randomized double-blind clinical trial was conducted in patients with advanced cervical cancer who had undergone external radiation therapy at Department of Radiotherapy, Cipto Mangunkusumo Hospital, Jakarta, between April 2013 and April 2014. The inflammatory status was evaluated based on serum prostaglandin E2 (PGE2) levels using ELISA method. The dietary supplementation was isocaloric, isoprotein and contained PUFA with a ratio of ω-6: ω-3 fatty acid = 1.27:1 and supplementation without PUFA. Data were analyzed with statistical tests, including Shapiro-Wilk test, independent T-test and Mann–Whitney test. Results: there was statistically no significant difference on PGE2 level between treatment and control groups (p=0.127). However, there was clinically significant difference, in which the treatment group had reduced PGE2 level by 8.9%; while the control group had increased level by 28.1%. Conclusion: dietary supplementation enriched with PUFA can reduce inflammatory status in patients with advanced cervical cancer. Reduced PGE2 level will lower the survival of cancer cells; therefore dietary supplementation enriched with PUFA with a ratio of ω-6 : ω-3 fatty acid = 1.27 : 1 along with radiation therapy may improve tumor response to radiation.
Key words: cervical cancer, ω-3 PUFA, ω-6 PUFA, PGE2 level. |
| format | Article |
| id | doaj-art-4bb75475b8984b02b4971502129b1d3c |
| institution | Kabale University |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-4bb75475b8984b02b4971502129b1d3c2025-08-20T03:41:01ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322016-05-01471The Effect of High Poly Unsaturated Fatty Acid (PUFA) Dietary Supplementation on Inflammatory Status of Patients with Advanced Cervical Cancer on Radiation TreatmentSri Wuryanti0Andrijono Andrijono1Susworo Susworo2Fiastuti Witjaksono3Faculty of Medicine YARSI University, Jakarta, IndonesiaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Radiotherapy, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Clinical Nutrition, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaAim: to identify the effect of high-PUFA dietary supplementation on inflammatory status of patients with advanced cervical cancer. Methods: a randomized double-blind clinical trial was conducted in patients with advanced cervical cancer who had undergone external radiation therapy at Department of Radiotherapy, Cipto Mangunkusumo Hospital, Jakarta, between April 2013 and April 2014. The inflammatory status was evaluated based on serum prostaglandin E2 (PGE2) levels using ELISA method. The dietary supplementation was isocaloric, isoprotein and contained PUFA with a ratio of ω-6: ω-3 fatty acid = 1.27:1 and supplementation without PUFA. Data were analyzed with statistical tests, including Shapiro-Wilk test, independent T-test and Mann–Whitney test. Results: there was statistically no significant difference on PGE2 level between treatment and control groups (p=0.127). However, there was clinically significant difference, in which the treatment group had reduced PGE2 level by 8.9%; while the control group had increased level by 28.1%. Conclusion: dietary supplementation enriched with PUFA can reduce inflammatory status in patients with advanced cervical cancer. Reduced PGE2 level will lower the survival of cancer cells; therefore dietary supplementation enriched with PUFA with a ratio of ω-6 : ω-3 fatty acid = 1.27 : 1 along with radiation therapy may improve tumor response to radiation. Key words: cervical cancer, ω-3 PUFA, ω-6 PUFA, PGE2 level.http://actamedindones.org/index.php/ijim/article/view/8 |
| spellingShingle | Sri Wuryanti Andrijono Andrijono Susworo Susworo Fiastuti Witjaksono The Effect of High Poly Unsaturated Fatty Acid (PUFA) Dietary Supplementation on Inflammatory Status of Patients with Advanced Cervical Cancer on Radiation Treatment Acta Medica Indonesiana |
| title | The Effect of High Poly Unsaturated Fatty Acid (PUFA) Dietary Supplementation on Inflammatory Status of Patients with Advanced Cervical Cancer on Radiation Treatment |
| title_full | The Effect of High Poly Unsaturated Fatty Acid (PUFA) Dietary Supplementation on Inflammatory Status of Patients with Advanced Cervical Cancer on Radiation Treatment |
| title_fullStr | The Effect of High Poly Unsaturated Fatty Acid (PUFA) Dietary Supplementation on Inflammatory Status of Patients with Advanced Cervical Cancer on Radiation Treatment |
| title_full_unstemmed | The Effect of High Poly Unsaturated Fatty Acid (PUFA) Dietary Supplementation on Inflammatory Status of Patients with Advanced Cervical Cancer on Radiation Treatment |
| title_short | The Effect of High Poly Unsaturated Fatty Acid (PUFA) Dietary Supplementation on Inflammatory Status of Patients with Advanced Cervical Cancer on Radiation Treatment |
| title_sort | effect of high poly unsaturated fatty acid pufa dietary supplementation on inflammatory status of patients with advanced cervical cancer on radiation treatment |
| url | http://actamedindones.org/index.php/ijim/article/view/8 |
| work_keys_str_mv | AT sriwuryanti theeffectofhighpolyunsaturatedfattyacidpufadietarysupplementationoninflammatorystatusofpatientswithadvancedcervicalcanceronradiationtreatment AT andrijonoandrijono theeffectofhighpolyunsaturatedfattyacidpufadietarysupplementationoninflammatorystatusofpatientswithadvancedcervicalcanceronradiationtreatment AT susworosusworo theeffectofhighpolyunsaturatedfattyacidpufadietarysupplementationoninflammatorystatusofpatientswithadvancedcervicalcanceronradiationtreatment AT fiastutiwitjaksono theeffectofhighpolyunsaturatedfattyacidpufadietarysupplementationoninflammatorystatusofpatientswithadvancedcervicalcanceronradiationtreatment AT sriwuryanti effectofhighpolyunsaturatedfattyacidpufadietarysupplementationoninflammatorystatusofpatientswithadvancedcervicalcanceronradiationtreatment AT andrijonoandrijono effectofhighpolyunsaturatedfattyacidpufadietarysupplementationoninflammatorystatusofpatientswithadvancedcervicalcanceronradiationtreatment AT susworosusworo effectofhighpolyunsaturatedfattyacidpufadietarysupplementationoninflammatorystatusofpatientswithadvancedcervicalcanceronradiationtreatment AT fiastutiwitjaksono effectofhighpolyunsaturatedfattyacidpufadietarysupplementationoninflammatorystatusofpatientswithadvancedcervicalcanceronradiationtreatment |