Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis
Objectives. In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis (SpA). Patients and Methods. We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO. We assessed extra-articular symptoms in al...
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| Format: | Article |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/7617954 |
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| author | Hanna Przepiera-Będzak Katarzyna Fischer Marek Brzosko |
| author_facet | Hanna Przepiera-Będzak Katarzyna Fischer Marek Brzosko |
| author_sort | Hanna Przepiera-Będzak |
| collection | DOAJ |
| description | Objectives. In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis (SpA). Patients and Methods. We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO. We assessed extra-articular symptoms in all cases. In 191 SpA patients, we measured serum interleukin-6 (IL-6), interleukin-18 (IL-18), interleukin-23 (IL-23), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). Results. Patients with acute anterior uveitis (AAU) had higher VAS (P=0.0008), BADSDAI (P=0.0001), ASDAS-ESR (P=0.04), CRP (P=0.006), IL-6 (P=0.02), and IL-18 (P=0.03) levels. Patients with inflammatory bowel disease (IBD) had higher VAS (P=0.03), CRP (P=0.0009), and IL-6 (P=0.0003) levels. Patients with skin psoriasis had lower VAS (P=0.001) and BASDAI (P=0.00007) levels. Patients with psoriatic onycholysis had lower VAS (P=0.006), BASDAI (P=0.00001), and CRP (P=0.02) and higher IL-23 (P=0.04) levels. Patients with PPP had lower BASDAI (P=0.04) and higher ET-1 (P=0.001) levels. Conclusions. SpA patients with increased serum IL-18 and decreased serum ET-1 had an increased risk of extra-articular symptoms. In SpA patients, increased disease activity was associated with an increased risk of AAU and IBD and a decreased risk of skin psoriasis, psoriatic onycholysis, and PPP. |
| format | Article |
| id | doaj-art-4bb546198ffb469aac4de5c64f37306d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4bb546198ffb469aac4de5c64f37306d2025-02-03T01:24:31ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/76179547617954Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in SpondyloarthritisHanna Przepiera-Będzak0Katarzyna Fischer1Marek Brzosko2Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, PolandIndependent Laboratory of Rheumatic Diagnostics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, PolandObjectives. In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis (SpA). Patients and Methods. We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO. We assessed extra-articular symptoms in all cases. In 191 SpA patients, we measured serum interleukin-6 (IL-6), interleukin-18 (IL-18), interleukin-23 (IL-23), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). Results. Patients with acute anterior uveitis (AAU) had higher VAS (P=0.0008), BADSDAI (P=0.0001), ASDAS-ESR (P=0.04), CRP (P=0.006), IL-6 (P=0.02), and IL-18 (P=0.03) levels. Patients with inflammatory bowel disease (IBD) had higher VAS (P=0.03), CRP (P=0.0009), and IL-6 (P=0.0003) levels. Patients with skin psoriasis had lower VAS (P=0.001) and BASDAI (P=0.00007) levels. Patients with psoriatic onycholysis had lower VAS (P=0.006), BASDAI (P=0.00001), and CRP (P=0.02) and higher IL-23 (P=0.04) levels. Patients with PPP had lower BASDAI (P=0.04) and higher ET-1 (P=0.001) levels. Conclusions. SpA patients with increased serum IL-18 and decreased serum ET-1 had an increased risk of extra-articular symptoms. In SpA patients, increased disease activity was associated with an increased risk of AAU and IBD and a decreased risk of skin psoriasis, psoriatic onycholysis, and PPP.http://dx.doi.org/10.1155/2016/7617954 |
| spellingShingle | Hanna Przepiera-Będzak Katarzyna Fischer Marek Brzosko Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis Mediators of Inflammation |
| title | Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis |
| title_full | Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis |
| title_fullStr | Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis |
| title_full_unstemmed | Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis |
| title_short | Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis |
| title_sort | extra articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis |
| url | http://dx.doi.org/10.1155/2016/7617954 |
| work_keys_str_mv | AT hannaprzepierabedzak extraarticularsymptomsinconstellationwithselectedserumcytokinesanddiseaseactivityinspondyloarthritis AT katarzynafischer extraarticularsymptomsinconstellationwithselectedserumcytokinesanddiseaseactivityinspondyloarthritis AT marekbrzosko extraarticularsymptomsinconstellationwithselectedserumcytokinesanddiseaseactivityinspondyloarthritis |