DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS
Abstract. The aim of this study was to detect some features of autoreactive IgM production that interact with IgGs and normal human cellular antigens in blood sera of patients with acute respiratory viral infections caused by various factors, dependent on their age and clinical features of disease....
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| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/153 |
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| author | V. Z. Krivitskaya M. V. Sverlova V. F. Sukhovetskaya N. I. Lvov I. A. Vassilieva A. A. Sominina |
| author_facet | V. Z. Krivitskaya M. V. Sverlova V. F. Sukhovetskaya N. I. Lvov I. A. Vassilieva A. A. Sominina |
| author_sort | V. Z. Krivitskaya |
| collection | DOAJ |
| description | Abstract. The aim of this study was to detect some features of autoreactive IgM production that interact with IgGs and normal human cellular antigens in blood sera of patients with acute respiratory viral infections caused by various factors, dependent on their age and clinical features of disease. The antibody concentrations were determined by immunoenzyme technique in paired serum samples from 750 patients and single specimens from 97 healthy persons. The results of analysis have shown that the studied types of autoreactive IgM represent a normal component of humoral immunity, since they are detectable in sufficient number of normal sera from healthy persons over 3 years old. In acute respiratory viral infections of different etiology, the rates of appropriate seroconversions comprised 0 to 16% for age cohort of < 3 years old. Incidence of seroconversions reached 37% among older children and adult patients with respiratory syncitial virus (RSV), or adenoviral infection, thus being 1.7 to 5.1-fold higher than in patients with influenza A, or B, or parainfluenza. In cases of clinical complications of RSV or parainfluenza infections (i.e., respiratory tract obstruction, or pneumonia), the rates of seroconversions to autoreactive IgMs was 1.4 to1.8-fold higher than among the patients with uncomplicated clinical course of these infections. (Med. Immunol., 2008, vol. 10, N 2-3, pp 229-238). |
| format | Article |
| id | doaj-art-4bb1d317a3ca40718d4b843ac7edf880 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-4bb1d317a3ca40718d4b843ac7edf8802025-08-20T03:44:07ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01102-322923810.15789/1563-0625-2008-2-3-229-238150DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONSV. Z. Krivitskaya0M. V. Sverlova1V. F. Sukhovetskaya2N. I. Lvov3I. A. Vassilieva4A. A. Sominina5ГУ Научно-исследовательский институт гриппа РАМН, Санкт-ПетербургГУ Научно-исследовательский институт гриппа РАМН, Санкт-ПетербургГУ Научно-исследовательский институт гриппа РАМН, Санкт-ПетербургВоенно-медицинская академия им. С.М. Кирова, Санкт-ПетербургГУ Научно-исследовательский институт гриппа РАМН, Санкт-ПетербургГУ Научно-исследовательский институт гриппа РАМН, Санкт-ПетербургAbstract. The aim of this study was to detect some features of autoreactive IgM production that interact with IgGs and normal human cellular antigens in blood sera of patients with acute respiratory viral infections caused by various factors, dependent on their age and clinical features of disease. The antibody concentrations were determined by immunoenzyme technique in paired serum samples from 750 patients and single specimens from 97 healthy persons. The results of analysis have shown that the studied types of autoreactive IgM represent a normal component of humoral immunity, since they are detectable in sufficient number of normal sera from healthy persons over 3 years old. In acute respiratory viral infections of different etiology, the rates of appropriate seroconversions comprised 0 to 16% for age cohort of < 3 years old. Incidence of seroconversions reached 37% among older children and adult patients with respiratory syncitial virus (RSV), or adenoviral infection, thus being 1.7 to 5.1-fold higher than in patients with influenza A, or B, or parainfluenza. In cases of clinical complications of RSV or parainfluenza infections (i.e., respiratory tract obstruction, or pneumonia), the rates of seroconversions to autoreactive IgMs was 1.4 to1.8-fold higher than among the patients with uncomplicated clinical course of these infections. (Med. Immunol., 2008, vol. 10, N 2-3, pp 229-238).https://www.mimmun.ru/mimmun/article/view/153autoreactive igmacute respiratory viral infectionschildrenadult patients |
| spellingShingle | V. Z. Krivitskaya M. V. Sverlova V. F. Sukhovetskaya N. I. Lvov I. A. Vassilieva A. A. Sominina DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS Медицинская иммунология autoreactive igm acute respiratory viral infections children adult patients |
| title | DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS |
| title_full | DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS |
| title_fullStr | DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS |
| title_full_unstemmed | DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS |
| title_short | DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS |
| title_sort | detection of autoreactive class m antibodies in patients with respiratory viral infections |
| topic | autoreactive igm acute respiratory viral infections children adult patients |
| url | https://www.mimmun.ru/mimmun/article/view/153 |
| work_keys_str_mv | AT vzkrivitskaya detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections AT mvsverlova detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections AT vfsukhovetskaya detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections AT nilvov detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections AT iavassilieva detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections AT aasominina detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections |