Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice.
Atherosclerosis is the main underlying cause for cardiovascular events such as myocardial infarction and stroke and its development might be influenced by immune cells. Dendritic cells (DCs) bridge innate and adaptive immune responses by presenting antigens to T cells and releasing a variety of cyto...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181947&type=printable |
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| author | Jesus Gil-Pulido Clement Cochain Malte A Lippert Nicole Schneider Elke Butt Núria Amézaga Alma Zernecke |
| author_facet | Jesus Gil-Pulido Clement Cochain Malte A Lippert Nicole Schneider Elke Butt Núria Amézaga Alma Zernecke |
| author_sort | Jesus Gil-Pulido |
| collection | DOAJ |
| description | Atherosclerosis is the main underlying cause for cardiovascular events such as myocardial infarction and stroke and its development might be influenced by immune cells. Dendritic cells (DCs) bridge innate and adaptive immune responses by presenting antigens to T cells and releasing a variety of cytokines. Several subsets of DCs can be discriminated that engage specific transcriptional pathways for their development. Basic leucine zipper transcription factor ATF-like 3 (Batf3) is required for the development of classical CD8α+ and CD103+ DCs. By crossing mice deficient in Batf3 with atherosclerosis-prone low density lipoprotein receptor (Ldlr-/-)-deficient mice we here aimed to further address the contribution of Batf3-dependent CD8α+ and CD103+ antigen-presenting cells to atherosclerosis. We demonstrate that deficiency in Batf3 entailed mild effects on the immune response in the spleen but did not alter atherosclerotic lesion formation in the aorta or aortic root, nor affected plaque phenotype in low density lipoprotein receptor-deficient mice fed a high fat diet. We thus provide evidence that Batf3-dependent antigen-presenting cells do not have a prominent role in atherosclerosis. |
| format | Article |
| id | doaj-art-4ba99e53a63b43899bb55b41046166a3 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-4ba99e53a63b43899bb55b41046166a32025-08-20T02:03:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018194710.1371/journal.pone.0181947Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice.Jesus Gil-PulidoClement CochainMalte A LippertNicole SchneiderElke ButtNúria AmézagaAlma ZerneckeAtherosclerosis is the main underlying cause for cardiovascular events such as myocardial infarction and stroke and its development might be influenced by immune cells. Dendritic cells (DCs) bridge innate and adaptive immune responses by presenting antigens to T cells and releasing a variety of cytokines. Several subsets of DCs can be discriminated that engage specific transcriptional pathways for their development. Basic leucine zipper transcription factor ATF-like 3 (Batf3) is required for the development of classical CD8α+ and CD103+ DCs. By crossing mice deficient in Batf3 with atherosclerosis-prone low density lipoprotein receptor (Ldlr-/-)-deficient mice we here aimed to further address the contribution of Batf3-dependent CD8α+ and CD103+ antigen-presenting cells to atherosclerosis. We demonstrate that deficiency in Batf3 entailed mild effects on the immune response in the spleen but did not alter atherosclerotic lesion formation in the aorta or aortic root, nor affected plaque phenotype in low density lipoprotein receptor-deficient mice fed a high fat diet. We thus provide evidence that Batf3-dependent antigen-presenting cells do not have a prominent role in atherosclerosis.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181947&type=printable |
| spellingShingle | Jesus Gil-Pulido Clement Cochain Malte A Lippert Nicole Schneider Elke Butt Núria Amézaga Alma Zernecke Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice. PLoS ONE |
| title | Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice. |
| title_full | Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice. |
| title_fullStr | Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice. |
| title_full_unstemmed | Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice. |
| title_short | Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice. |
| title_sort | deletion of batf3 dependent antigen presenting cells does not affect atherosclerotic lesion formation in mice |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181947&type=printable |
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