From Mechanism to Therapy: The Role of MSC-EVs in Alleviating Radiation-Induced Injuries
Radiation injury is a severe issue in both nuclear accidents and cancer radiotherapy. Ionizing radiation impairs the regenerative and repair capabilities of tissues and organs, resulting in a scarcity of effective therapeutic approaches to prevent or mitigate such injuries. Mesenchymal stem cells (M...
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2025-05-01
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| author | Chong Huang Heng Li Zhiyue Zhang Ting Mou Dandan Wang Chenlu Li Lei Tian Chunlin Zong |
| author_facet | Chong Huang Heng Li Zhiyue Zhang Ting Mou Dandan Wang Chenlu Li Lei Tian Chunlin Zong |
| author_sort | Chong Huang |
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| description | Radiation injury is a severe issue in both nuclear accidents and cancer radiotherapy. Ionizing radiation impairs the regenerative and repair capabilities of tissues and organs, resulting in a scarcity of effective therapeutic approaches to prevent or mitigate such injuries. Mesenchymal stem cells (MSCs) possess favorable biological characteristics and have emerged as ideal candidates for the treatment of radiation injury. However, the use of MSCs as therapeutic agents is associated with uncertainties in therapeutic efficacy, transient effects, and the risk of immune rejection. Recent advances in research have revealed that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSC-EVs) exhibit similar beneficial properties to MSCs and represent a promising cell-free therapy for mitigating radiation injuries. MSC-EVs are enriched with microRNAs (miRNAs), proteins, and lipids, which can modulate immune responses, inflammatory reactions, cell survival, and proliferation in irradiated tissues. This review synthesizes recent studies on the application of MSC-EVs in radiation injury, focusing on the therapeutic effects and mechanisms of MSC-EVs derived from various sources in radiation-induced diseases of different organs. The therapeutic potential of MSC-EVs for radiation injury provides valuable insights for addressing ionizing radiation-induced injuries and offers a reference for future clinical applications. |
| format | Article |
| id | doaj-art-4ba94b41ed2b4345b3a6cc43cf7e18b8 |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj-art-4ba94b41ed2b4345b3a6cc43cf7e18b82025-08-20T01:56:44ZengMDPI AGPharmaceutics1999-49232025-05-0117565210.3390/pharmaceutics17050652From Mechanism to Therapy: The Role of MSC-EVs in Alleviating Radiation-Induced InjuriesChong Huang0Heng Li1Zhiyue Zhang2Ting Mou3Dandan Wang4Chenlu Li5Lei Tian6Chunlin Zong7State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, ChinaSchool of Stomatology, Jiamusi University, Jiamusi 154007, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, ChinaRadiation injury is a severe issue in both nuclear accidents and cancer radiotherapy. Ionizing radiation impairs the regenerative and repair capabilities of tissues and organs, resulting in a scarcity of effective therapeutic approaches to prevent or mitigate such injuries. Mesenchymal stem cells (MSCs) possess favorable biological characteristics and have emerged as ideal candidates for the treatment of radiation injury. However, the use of MSCs as therapeutic agents is associated with uncertainties in therapeutic efficacy, transient effects, and the risk of immune rejection. Recent advances in research have revealed that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSC-EVs) exhibit similar beneficial properties to MSCs and represent a promising cell-free therapy for mitigating radiation injuries. MSC-EVs are enriched with microRNAs (miRNAs), proteins, and lipids, which can modulate immune responses, inflammatory reactions, cell survival, and proliferation in irradiated tissues. This review synthesizes recent studies on the application of MSC-EVs in radiation injury, focusing on the therapeutic effects and mechanisms of MSC-EVs derived from various sources in radiation-induced diseases of different organs. The therapeutic potential of MSC-EVs for radiation injury provides valuable insights for addressing ionizing radiation-induced injuries and offers a reference for future clinical applications.https://www.mdpi.com/1999-4923/17/5/652mesenchymal stem cellsextracellular vesiclesradiation-induced injuries |
| spellingShingle | Chong Huang Heng Li Zhiyue Zhang Ting Mou Dandan Wang Chenlu Li Lei Tian Chunlin Zong From Mechanism to Therapy: The Role of MSC-EVs in Alleviating Radiation-Induced Injuries Pharmaceutics mesenchymal stem cells extracellular vesicles radiation-induced injuries |
| title | From Mechanism to Therapy: The Role of MSC-EVs in Alleviating Radiation-Induced Injuries |
| title_full | From Mechanism to Therapy: The Role of MSC-EVs in Alleviating Radiation-Induced Injuries |
| title_fullStr | From Mechanism to Therapy: The Role of MSC-EVs in Alleviating Radiation-Induced Injuries |
| title_full_unstemmed | From Mechanism to Therapy: The Role of MSC-EVs in Alleviating Radiation-Induced Injuries |
| title_short | From Mechanism to Therapy: The Role of MSC-EVs in Alleviating Radiation-Induced Injuries |
| title_sort | from mechanism to therapy the role of msc evs in alleviating radiation induced injuries |
| topic | mesenchymal stem cells extracellular vesicles radiation-induced injuries |
| url | https://www.mdpi.com/1999-4923/17/5/652 |
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