Click-cross-linked, doxorubicin-loaded hydrogels based on poly(styrene-alt-maleic anhydride)
A new type of hydrogels based on poly(styrene-alt-maleic anhydride) (PSMA) was prepared via Diels-Alder click chemistry. The formulations consisting of tetrazine-functionalized PSMA as a multi-clickable polymer and norbornene-terminated poly(ethylene glycol) (PEG) as a polymeric cross-linker were us...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Budapest University of Technology and Economics
2020-03-01
|
| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0010228&mi=cd |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849246898869764096 |
|---|---|
| author | D. S. B. Anugrah M. P. Patil X. Li C. M. Q. Le K. Ramesh G-D. Kim K. Hyun K. T. Lim |
| author_facet | D. S. B. Anugrah M. P. Patil X. Li C. M. Q. Le K. Ramesh G-D. Kim K. Hyun K. T. Lim |
| author_sort | D. S. B. Anugrah |
| collection | DOAJ |
| description | A new type of hydrogels based on poly(styrene-alt-maleic anhydride) (PSMA) was prepared via Diels-Alder click chemistry. The formulations consisting of tetrazine-functionalized PSMA as a multi-clickable polymer and norbornene-terminated poly(ethylene glycol) (PEG) as a polymeric cross-linker were used as precursors to give ultrafast hydrogels with controlled structures. The hydrogels formed within several minutes under a physiological condition without any catalyst, and their storage modulus (G′) values were in the range 0.3–1.7 kPa suitable for bio-applications. The pore structure and the release profile of doxorubicin hydrochloride (DOX・HCl) of the hydrogels could be manipulated by the molecular weight of PEG. The precursors exhibited practically no depressing effect of the normal HEK293 growth, while the DOX・HCl-loaded hydrogel presented significant anticancer activity towards HeLa cells. The results suggested this biocompatible hydrogel as a potential injectable drug depot for tumor sites. |
| format | Article |
| id | doaj-art-4ba6fb02450341e6a336fa6eb5f4c689 |
| institution | Kabale University |
| issn | 1788-618X |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-4ba6fb02450341e6a336fa6eb5f4c6892025-08-20T03:58:22ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2020-03-0114324826010.3144/expresspolymlett.2020.21Click-cross-linked, doxorubicin-loaded hydrogels based on poly(styrene-alt-maleic anhydride)D. S. B. AnugrahM. P. PatilX. LiC. M. Q. LeK. RameshG-D. KimK. HyunK. T. LimA new type of hydrogels based on poly(styrene-alt-maleic anhydride) (PSMA) was prepared via Diels-Alder click chemistry. The formulations consisting of tetrazine-functionalized PSMA as a multi-clickable polymer and norbornene-terminated poly(ethylene glycol) (PEG) as a polymeric cross-linker were used as precursors to give ultrafast hydrogels with controlled structures. The hydrogels formed within several minutes under a physiological condition without any catalyst, and their storage modulus (G′) values were in the range 0.3–1.7 kPa suitable for bio-applications. The pore structure and the release profile of doxorubicin hydrochloride (DOX・HCl) of the hydrogels could be manipulated by the molecular weight of PEG. The precursors exhibited practically no depressing effect of the normal HEK293 growth, while the DOX・HCl-loaded hydrogel presented significant anticancer activity towards HeLa cells. The results suggested this biocompatible hydrogel as a potential injectable drug depot for tumor sites.http://www.expresspolymlett.com/letolt.php?file=EPL-0010228&mi=cdpolymer gelsinjectable hydrogelpoly(styrene-alt-maleic anhydride)raft polymerizationtetrazine-norbornene click reaction |
| spellingShingle | D. S. B. Anugrah M. P. Patil X. Li C. M. Q. Le K. Ramesh G-D. Kim K. Hyun K. T. Lim Click-cross-linked, doxorubicin-loaded hydrogels based on poly(styrene-alt-maleic anhydride) eXPRESS Polymer Letters polymer gels injectable hydrogel poly(styrene-alt-maleic anhydride) raft polymerization tetrazine-norbornene click reaction |
| title | Click-cross-linked, doxorubicin-loaded hydrogels based on poly(styrene-alt-maleic anhydride) |
| title_full | Click-cross-linked, doxorubicin-loaded hydrogels based on poly(styrene-alt-maleic anhydride) |
| title_fullStr | Click-cross-linked, doxorubicin-loaded hydrogels based on poly(styrene-alt-maleic anhydride) |
| title_full_unstemmed | Click-cross-linked, doxorubicin-loaded hydrogels based on poly(styrene-alt-maleic anhydride) |
| title_short | Click-cross-linked, doxorubicin-loaded hydrogels based on poly(styrene-alt-maleic anhydride) |
| title_sort | click cross linked doxorubicin loaded hydrogels based on poly styrene alt maleic anhydride |
| topic | polymer gels injectable hydrogel poly(styrene-alt-maleic anhydride) raft polymerization tetrazine-norbornene click reaction |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0010228&mi=cd |
| work_keys_str_mv | AT dsbanugrah clickcrosslinkeddoxorubicinloadedhydrogelsbasedonpolystyrenealtmaleicanhydride AT mppatil clickcrosslinkeddoxorubicinloadedhydrogelsbasedonpolystyrenealtmaleicanhydride AT xli clickcrosslinkeddoxorubicinloadedhydrogelsbasedonpolystyrenealtmaleicanhydride AT cmqle clickcrosslinkeddoxorubicinloadedhydrogelsbasedonpolystyrenealtmaleicanhydride AT kramesh clickcrosslinkeddoxorubicinloadedhydrogelsbasedonpolystyrenealtmaleicanhydride AT gdkim clickcrosslinkeddoxorubicinloadedhydrogelsbasedonpolystyrenealtmaleicanhydride AT khyun clickcrosslinkeddoxorubicinloadedhydrogelsbasedonpolystyrenealtmaleicanhydride AT ktlim clickcrosslinkeddoxorubicinloadedhydrogelsbasedonpolystyrenealtmaleicanhydride |