Association Analysis of COQ2 Variant in Dementia and Essential Tremor
Objective. COQ2 mutations have been reported in Japanese multiple system atrophy (MSA) patients. We examined the role of COQ2 in patients with dementia and essential tremor (ET), two common neurodegenerative conditions. Materials & Methods. A total of 2064 subjects, including 560 patients with d...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/926280 |
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| author | Yin Xia Chao Ebonne Yu Lin Ng Huihua Li Kandiah Nagaendran Yuen Yih Mei Sian Chong Kumar M. Prakash Louis Tan Wing Lok Au Yi Zhao Zhi Dong Zhou Murni Tio Ratnagopal Pavanni Eng King Tan |
| author_facet | Yin Xia Chao Ebonne Yu Lin Ng Huihua Li Kandiah Nagaendran Yuen Yih Mei Sian Chong Kumar M. Prakash Louis Tan Wing Lok Au Yi Zhao Zhi Dong Zhou Murni Tio Ratnagopal Pavanni Eng King Tan |
| author_sort | Yin Xia Chao |
| collection | DOAJ |
| description | Objective. COQ2 mutations have been reported in Japanese multiple system atrophy (MSA) patients. We examined the role of COQ2 in patients with dementia and essential tremor (ET), two common neurodegenerative conditions. Materials & Methods. A total of 2064 subjects, including 560 patients with dementia, 466 patients with ET, and 1038 healthy controls, were included. Genotyping for the COQ2 V393A (T>C) was carried out. Odds ratio (OR) adjusted by age and gender, together with 95% confidence interval (CI), was reported by means of logistic regression. Results. The frequency of the polymorphic variant V393A heterozygous (T/C) was 2.7% in dementia, 1.1% in ET, and 2.5% in controls (OR = 0.70, 95% confidence interval is 0.29–1.72 for dementia, and OR = 0.47, 95% confidence interval is 0.17–1.31, p=0.1217 for ET). There was no significant association between V393A variant with dementia and ET. Conclusion. There was no significant association between V393A variant with dementia and ET. COQ2 gene is unlikely to play a significant role in patients with dementia or ET in our population. |
| format | Article |
| id | doaj-art-4b9cdc49ba1b441eba853a2dc0ddca30 |
| institution | OA Journals |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-4b9cdc49ba1b441eba853a2dc0ddca302025-08-20T02:38:41ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/926280926280Association Analysis of COQ2 Variant in Dementia and Essential TremorYin Xia Chao0Ebonne Yu Lin Ng1Huihua Li2Kandiah Nagaendran3Yuen Yih4Mei Sian Chong5Kumar M. Prakash6Louis Tan7Wing Lok Au8Yi Zhao9Zhi Dong Zhou10Murni Tio11Ratnagopal Pavanni12Eng King Tan13Department of Neurology, Singapore General Hospital, 169608, SingaporeDepartment of Neurology, Singapore General Hospital, 169608, SingaporeDuke-NUS Graduate Medical School, 169857, SingaporeNational Neuroscience Institute, 308433, SingaporeHealth Assessment Centre, Singapore General Hospital, 169608, SingaporeInstitute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, 308433, SingaporeDepartment of Neurology, Singapore General Hospital, 169608, SingaporeNational Neuroscience Institute, 308433, SingaporeNational Neuroscience Institute, 308433, SingaporeDepartment of Clinical Research, Singapore General Hospital, 169608, SingaporeDepartment of Neurology, Singapore General Hospital, 169608, SingaporeDepartment of Neurology, Singapore General Hospital, 169608, SingaporeDepartment of Neurology, Singapore General Hospital, 169608, SingaporeDepartment of Neurology, Singapore General Hospital, 169608, SingaporeObjective. COQ2 mutations have been reported in Japanese multiple system atrophy (MSA) patients. We examined the role of COQ2 in patients with dementia and essential tremor (ET), two common neurodegenerative conditions. Materials & Methods. A total of 2064 subjects, including 560 patients with dementia, 466 patients with ET, and 1038 healthy controls, were included. Genotyping for the COQ2 V393A (T>C) was carried out. Odds ratio (OR) adjusted by age and gender, together with 95% confidence interval (CI), was reported by means of logistic regression. Results. The frequency of the polymorphic variant V393A heterozygous (T/C) was 2.7% in dementia, 1.1% in ET, and 2.5% in controls (OR = 0.70, 95% confidence interval is 0.29–1.72 for dementia, and OR = 0.47, 95% confidence interval is 0.17–1.31, p=0.1217 for ET). There was no significant association between V393A variant with dementia and ET. Conclusion. There was no significant association between V393A variant with dementia and ET. COQ2 gene is unlikely to play a significant role in patients with dementia or ET in our population.http://dx.doi.org/10.1155/2015/926280 |
| spellingShingle | Yin Xia Chao Ebonne Yu Lin Ng Huihua Li Kandiah Nagaendran Yuen Yih Mei Sian Chong Kumar M. Prakash Louis Tan Wing Lok Au Yi Zhao Zhi Dong Zhou Murni Tio Ratnagopal Pavanni Eng King Tan Association Analysis of COQ2 Variant in Dementia and Essential Tremor Parkinson's Disease |
| title | Association Analysis of COQ2 Variant in Dementia and Essential Tremor |
| title_full | Association Analysis of COQ2 Variant in Dementia and Essential Tremor |
| title_fullStr | Association Analysis of COQ2 Variant in Dementia and Essential Tremor |
| title_full_unstemmed | Association Analysis of COQ2 Variant in Dementia and Essential Tremor |
| title_short | Association Analysis of COQ2 Variant in Dementia and Essential Tremor |
| title_sort | association analysis of coq2 variant in dementia and essential tremor |
| url | http://dx.doi.org/10.1155/2015/926280 |
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