Impact of Goal-Oriented Therapy with Different Infusion Media on Pulmonary Extravascular Water Levels in Cardiac Surgery Patients
Objective: to study the impact of goal-oriented infusion therapy using balanced salt solution, 4% succinylated gelatin, and 6% hydroxyethyl starch 130/0.42 solution on pulmonary extravascular water levels in coronary heart disease patients operated on under extracorporeal circulation.Materials and m...
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2015-07-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1464 |
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| author | G. B. Moroz E. V. Fominsky A. N. Shilova A. M. Karaskov I. A. Kornilov M. G. Pustovetova V. V. Lomivorotov |
| author_facet | G. B. Moroz E. V. Fominsky A. N. Shilova A. M. Karaskov I. A. Kornilov M. G. Pustovetova V. V. Lomivorotov |
| author_sort | G. B. Moroz |
| collection | DOAJ |
| description | Objective: to study the impact of goal-oriented infusion therapy using balanced salt solution, 4% succinylated gelatin, and 6% hydroxyethyl starch 130/0.42 solution on pulmonary extravascular water levels in coronary heart disease patients operated on under extracorporeal circulation.Materials and methods. A prospective, randomized, single-blind clinical study investigating the impact of goal-oriented infusion therapy using balanced salt solution, 4% succinylated gelatin, and 6% hydroxyethyl starch 130/0.42 solution on pulmonary extravascular water levels was conducted in coronary heart disease patents operated on under extracorporeal circulation. The hemodynamic target was the global end-diastolic volume index which was maintained in the range from 680 to 850 ml/m2. Pulmonary extravascular water was measured by a transpulmonary thermodilution technique; hydrobalance, lactate, mixed venous oxygen saturation, hemodynamic parameters, and troponin I concentrations were also investigated.Results. Analysis of the values of the pulmonary extravascular water index revealed no differences between the groups in pulmonary extravascular water levels throughout the study. Large volumes of balanced crystalloid solution were required to maintain intraoperative and postoperative hemodynamics. Balance after surgery was considerably higher and amounted to 2000 [1415—2200] ml in the crystalloid group, 1020 [650—1563] ml in the gelatin group, and 1070 [550—1675] ml in the hydroxyethyl starch solution (p=0.001). Mixed venous oxygen saturation, lactate, and troponin I concentrations were comparable between the groups at the study stages.Conclusion. It was found the infusion therapy using balanced salt solution failed to result in an increase in pulmonary extravascular water levels in coronary heart disease patients operated on under extracorporeal circulation as did colloid solution-based infusion therapy. Achieving hemodynamic targets requires a large volume of crystalloid solution than the use of colloid infusion solution. |
| format | Article |
| id | doaj-art-4b9a692dab7e4a7c8ac1683f684af4fe |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-4b9a692dab7e4a7c8ac1683f684af4fe2025-08-20T03:35:07ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102015-07-01113546410.15360/1813-9779-2015-3-54-641454Impact of Goal-Oriented Therapy with Different Infusion Media on Pulmonary Extravascular Water Levels in Cardiac Surgery PatientsG. B. Moroz0E. V. Fominsky1A. N. Shilova2A. M. Karaskov3I. A. Kornilov4M. G. Pustovetova5V. V. Lomivorotov6Academician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationObjective: to study the impact of goal-oriented infusion therapy using balanced salt solution, 4% succinylated gelatin, and 6% hydroxyethyl starch 130/0.42 solution on pulmonary extravascular water levels in coronary heart disease patients operated on under extracorporeal circulation.Materials and methods. A prospective, randomized, single-blind clinical study investigating the impact of goal-oriented infusion therapy using balanced salt solution, 4% succinylated gelatin, and 6% hydroxyethyl starch 130/0.42 solution on pulmonary extravascular water levels was conducted in coronary heart disease patents operated on under extracorporeal circulation. The hemodynamic target was the global end-diastolic volume index which was maintained in the range from 680 to 850 ml/m2. Pulmonary extravascular water was measured by a transpulmonary thermodilution technique; hydrobalance, lactate, mixed venous oxygen saturation, hemodynamic parameters, and troponin I concentrations were also investigated.Results. Analysis of the values of the pulmonary extravascular water index revealed no differences between the groups in pulmonary extravascular water levels throughout the study. Large volumes of balanced crystalloid solution were required to maintain intraoperative and postoperative hemodynamics. Balance after surgery was considerably higher and amounted to 2000 [1415—2200] ml in the crystalloid group, 1020 [650—1563] ml in the gelatin group, and 1070 [550—1675] ml in the hydroxyethyl starch solution (p=0.001). Mixed venous oxygen saturation, lactate, and troponin I concentrations were comparable between the groups at the study stages.Conclusion. It was found the infusion therapy using balanced salt solution failed to result in an increase in pulmonary extravascular water levels in coronary heart disease patients operated on under extracorporeal circulation as did colloid solution-based infusion therapy. Achieving hemodynamic targets requires a large volume of crystalloid solution than the use of colloid infusion solution.https://www.reanimatology.com/rmt/article/view/1464infusion therapycrystalloid solutionscolloid solutionstranspulmonary thermodilutionpulmonary extravascular waterglobal end-diastolic volume indexhydrobalance |
| spellingShingle | G. B. Moroz E. V. Fominsky A. N. Shilova A. M. Karaskov I. A. Kornilov M. G. Pustovetova V. V. Lomivorotov Impact of Goal-Oriented Therapy with Different Infusion Media on Pulmonary Extravascular Water Levels in Cardiac Surgery Patients Общая реаниматология infusion therapy crystalloid solutions colloid solutions transpulmonary thermodilution pulmonary extravascular water global end-diastolic volume index hydrobalance |
| title | Impact of Goal-Oriented Therapy with Different Infusion Media on Pulmonary Extravascular Water Levels in Cardiac Surgery Patients |
| title_full | Impact of Goal-Oriented Therapy with Different Infusion Media on Pulmonary Extravascular Water Levels in Cardiac Surgery Patients |
| title_fullStr | Impact of Goal-Oriented Therapy with Different Infusion Media on Pulmonary Extravascular Water Levels in Cardiac Surgery Patients |
| title_full_unstemmed | Impact of Goal-Oriented Therapy with Different Infusion Media on Pulmonary Extravascular Water Levels in Cardiac Surgery Patients |
| title_short | Impact of Goal-Oriented Therapy with Different Infusion Media on Pulmonary Extravascular Water Levels in Cardiac Surgery Patients |
| title_sort | impact of goal oriented therapy with different infusion media on pulmonary extravascular water levels in cardiac surgery patients |
| topic | infusion therapy crystalloid solutions colloid solutions transpulmonary thermodilution pulmonary extravascular water global end-diastolic volume index hydrobalance |
| url | https://www.reanimatology.com/rmt/article/view/1464 |
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