A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging
Abstract The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. SWIR spectral activity may also be accessed via supramolecular dye aggregation. Unfortunately, development of dye aggregation remains ch...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55445-x |
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| _version_ | 1850076539816771584 |
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| author | Cheng Yao Ruwei Wei Xiao Luo Jie Zhou Xiaodong Zhang Xicun Lu Yan Dong Ruofan Chu Yuxin Sun Yu Wang Wencheng Xia Dahui Qu Cong Liu Jun Ren Guangbo Ge Jinquan Chen Xuhong Qian Youjun Yang |
| author_facet | Cheng Yao Ruwei Wei Xiao Luo Jie Zhou Xiaodong Zhang Xicun Lu Yan Dong Ruofan Chu Yuxin Sun Yu Wang Wencheng Xia Dahui Qu Cong Liu Jun Ren Guangbo Ge Jinquan Chen Xuhong Qian Youjun Yang |
| author_sort | Cheng Yao |
| collection | DOAJ |
| description | Abstract The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. SWIR spectral activity may also be accessed via supramolecular dye aggregation. Unfortunately, development of dye aggregation remains challenging. We propose a crystal-aided aggregate synthesis (CAASH) approach to introduce a layer of rationality for the development of J-aggregate and the successful development of a water-soluble SWIR JV-aggregate with a bisbenzannulated silicon rhodamine scaffold (ESi5). The resulting SWIR-aggregates exhibit excellent stabilities toward organic solvents, pH, sonication, photobleaching, thiols, and endogenous oxidative species. Notably, the aggregates have a high structure-dependent melting temperature of ca. 330-335 K. In fact, the heating/annealing process can be exploited to reduce aggregation disorder. The aggregates are biocompatible and have broad potential in in vivo fluorescence and photoacoustic imaging and more. |
| format | Article |
| id | doaj-art-4b917c4d3ff7466e8123323f741b3144 |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-4b917c4d3ff7466e8123323f741b31442025-08-20T02:46:00ZengNature PortfolioNature Communications2041-17232025-01-0116111210.1038/s41467-024-55445-xA stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imagingCheng Yao0Ruwei Wei1Xiao Luo2Jie Zhou3Xiaodong Zhang4Xicun Lu5Yan Dong6Ruofan Chu7Yuxin Sun8Yu Wang9Wencheng Xia10Dahui Qu11Cong Liu12Jun Ren13Guangbo Ge14Jinquan Chen15Xuhong Qian16Youjun Yang17State Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyShanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal UniversityState Key Laboratory of Precision Spectroscopy, East China Normal UniversityState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyShanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal UniversityInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesHubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals & Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei UniversityInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese MedicineState Key Laboratory of Precision Spectroscopy, East China Normal UniversityState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyAbstract The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. SWIR spectral activity may also be accessed via supramolecular dye aggregation. Unfortunately, development of dye aggregation remains challenging. We propose a crystal-aided aggregate synthesis (CAASH) approach to introduce a layer of rationality for the development of J-aggregate and the successful development of a water-soluble SWIR JV-aggregate with a bisbenzannulated silicon rhodamine scaffold (ESi5). The resulting SWIR-aggregates exhibit excellent stabilities toward organic solvents, pH, sonication, photobleaching, thiols, and endogenous oxidative species. Notably, the aggregates have a high structure-dependent melting temperature of ca. 330-335 K. In fact, the heating/annealing process can be exploited to reduce aggregation disorder. The aggregates are biocompatible and have broad potential in in vivo fluorescence and photoacoustic imaging and more.https://doi.org/10.1038/s41467-024-55445-x |
| spellingShingle | Cheng Yao Ruwei Wei Xiao Luo Jie Zhou Xiaodong Zhang Xicun Lu Yan Dong Ruofan Chu Yuxin Sun Yu Wang Wencheng Xia Dahui Qu Cong Liu Jun Ren Guangbo Ge Jinquan Chen Xuhong Qian Youjun Yang A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging Nature Communications |
| title | A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging |
| title_full | A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging |
| title_fullStr | A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging |
| title_full_unstemmed | A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging |
| title_short | A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging |
| title_sort | stable and biocompatible shortwave infrared nanoribbon for dual channel in vivo imaging |
| url | https://doi.org/10.1038/s41467-024-55445-x |
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