Anti-Inflammatory Activity of Hydroxytriazenes and their Vanadium Complexes
The anti-inflammatory activity of hydroxytriazenes as well as their vanadium complexes has been studied using carrageenan induced hind paw oedema method in albino rats (Wister strain). Hydroxytriazenes viz., 3-hydroxy-1,3-diphenyltriazene (HT-1), 3-hydroxy-3-phenyl-1-(4-sulfonamido)phenyl triazene (...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/830737 |
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| author | Kalpana Singh Peeyush Patel A. K. Goswami |
| author_facet | Kalpana Singh Peeyush Patel A. K. Goswami |
| author_sort | Kalpana Singh |
| collection | DOAJ |
| description | The anti-inflammatory activity of hydroxytriazenes as well as their vanadium complexes has been studied using carrageenan induced hind paw oedema method in albino rats (Wister strain). Hydroxytriazenes viz., 3-hydroxy-1,3-diphenyltriazene (HT-1), 3-hydroxy-3-phenyl-1-(4-sulfonamido)phenyl triazene (HT-2), 3-hydroxy-3-p-chlorophenyl-1-(4-sulfonamido) phenyltriazene (HT-3), 3-hydroxy-3-m-chlorophenyl-1-(4-sulfonamido)phenyltriazene (HT-4)(HT-4) and their respective vanadium complexes C-1, C-2, C-3 and C-4 have been synthesized using standard methods, purified, characterized and used for studying their anti-inflammatory activities. The hind paw oedema was produced by subplanter injection of carrageenan and the paw volume was measured plethysmographically after 0.5, 1, 2, 3 and 5 h. The animals were given HT-1, HT-2, HT-3 and HT-4 and also vanadium complexes C-1, C-2, C-3 and C-4 dissolved in DMSO (at dose 5 mg/Kg body weight). Diclofenac sodium (5 mg/kg) was used as a standard drug. The standard drug shows maximum inibition up to 1h as 81.73% which goes on increasing up to 3h (88.94%) but further reduces to 74.93% at the end of 5 h. The test compounds i.e. both ligands as well as their metal complexes show maximum percent inhibition only up to 1h. after which the efficacy reduces. Thus it can be said that both ligands as well as their vanadium complexes show very significant anti-inflammatory activity up to 1h which is comparable to standard drug. |
| format | Article |
| id | doaj-art-4b8fdc112aff459f8bcc67b719524655 |
| institution | DOAJ |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-4b8fdc112aff459f8bcc67b7195246552025-08-20T03:20:14ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015S21144114810.1155/2008/830737Anti-Inflammatory Activity of Hydroxytriazenes and their Vanadium ComplexesKalpana Singh0Peeyush Patel1A. K. Goswami2Co-ordination Chemistry Laboratory, M.L. Sukhadia University, Udaipur 313001, IndiaCo-ordination Chemistry Laboratory, M.L. Sukhadia University, Udaipur 313001, IndiaCo-ordination Chemistry Laboratory, M.L. Sukhadia University, Udaipur 313001, IndiaThe anti-inflammatory activity of hydroxytriazenes as well as their vanadium complexes has been studied using carrageenan induced hind paw oedema method in albino rats (Wister strain). Hydroxytriazenes viz., 3-hydroxy-1,3-diphenyltriazene (HT-1), 3-hydroxy-3-phenyl-1-(4-sulfonamido)phenyl triazene (HT-2), 3-hydroxy-3-p-chlorophenyl-1-(4-sulfonamido) phenyltriazene (HT-3), 3-hydroxy-3-m-chlorophenyl-1-(4-sulfonamido)phenyltriazene (HT-4)(HT-4) and their respective vanadium complexes C-1, C-2, C-3 and C-4 have been synthesized using standard methods, purified, characterized and used for studying their anti-inflammatory activities. The hind paw oedema was produced by subplanter injection of carrageenan and the paw volume was measured plethysmographically after 0.5, 1, 2, 3 and 5 h. The animals were given HT-1, HT-2, HT-3 and HT-4 and also vanadium complexes C-1, C-2, C-3 and C-4 dissolved in DMSO (at dose 5 mg/Kg body weight). Diclofenac sodium (5 mg/kg) was used as a standard drug. The standard drug shows maximum inibition up to 1h as 81.73% which goes on increasing up to 3h (88.94%) but further reduces to 74.93% at the end of 5 h. The test compounds i.e. both ligands as well as their metal complexes show maximum percent inhibition only up to 1h. after which the efficacy reduces. Thus it can be said that both ligands as well as their vanadium complexes show very significant anti-inflammatory activity up to 1h which is comparable to standard drug.http://dx.doi.org/10.1155/2008/830737 |
| spellingShingle | Kalpana Singh Peeyush Patel A. K. Goswami Anti-Inflammatory Activity of Hydroxytriazenes and their Vanadium Complexes E-Journal of Chemistry |
| title | Anti-Inflammatory Activity of Hydroxytriazenes and their Vanadium Complexes |
| title_full | Anti-Inflammatory Activity of Hydroxytriazenes and their Vanadium Complexes |
| title_fullStr | Anti-Inflammatory Activity of Hydroxytriazenes and their Vanadium Complexes |
| title_full_unstemmed | Anti-Inflammatory Activity of Hydroxytriazenes and their Vanadium Complexes |
| title_short | Anti-Inflammatory Activity of Hydroxytriazenes and their Vanadium Complexes |
| title_sort | anti inflammatory activity of hydroxytriazenes and their vanadium complexes |
| url | http://dx.doi.org/10.1155/2008/830737 |
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