Analysis of exhaled nitric oxide and its influencing factors in patients with chronic obstructive pulmonary disease
ObjectivesTo compare exhaled nitric oxide (eNO) levels between patients with chronic obstructive pulmonary disease (COPD) and healthy controls, and to investigate factors influencing eNO measurements.MethodsThe study included 115 patients with acute exacerbation of chronic obstructive pulmonary dise...
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Frontiers Media S.A.
2025-07-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1611947/full |
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| author | Ya Shen Li-Li Yang Guo-Lan Ning Xiao-Bao Teng Jing-Feng Shi Shun-Shun Cui Zi-Xiao Cao Yan-Bei Zhang Ming-Feng Han |
| author_facet | Ya Shen Li-Li Yang Guo-Lan Ning Xiao-Bao Teng Jing-Feng Shi Shun-Shun Cui Zi-Xiao Cao Yan-Bei Zhang Ming-Feng Han |
| author_sort | Ya Shen |
| collection | DOAJ |
| description | ObjectivesTo compare exhaled nitric oxide (eNO) levels between patients with chronic obstructive pulmonary disease (COPD) and healthy controls, and to investigate factors influencing eNO measurements.MethodsThe study included 115 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), 89 patients with stable COPD, and 70 healthy medical checkups, and the basic data and eNO of the three groups were collected.ResultsConcentration of alveolar Nitric Oxide (CaNO) was higher in the AECOPD group than in the COPD and healthy control groups, nitric oxide concentration in exhaled breath at a flow rate of 200 ml/s (FeNO200) was higher in the AECOPD group than in the healthy control group, and the difference was significant. In the AECOPD group, non-smokers and ex-smokers had higher nitric oxide concentration in exhaled breath at a flow rate of 50 ml/s (FeNO50) and joint analysis of washout nitric oxide (JawNO) than current smokers. In the healthy control group, FeNO50 was higher in non-smokers and ex-smokers than in current-smokers, and JawNO was higher in non-smokers than in current-smokers. In the AECOPD group, non-smokers also had higher FeNO200 than current smokers, there was no difference in the comparison of CaNO for different smoking states in the three groups. In the COPD group, BMI was negatively correlated with FeNO50, FeNO200, and CaNO; height was positively correlated with FeNO200 and CaNO. Patients who inhaled Corticosteroids (ICS) had lower FeNO50, FeNO200, and JawNO than patients who did not inhale ICS in the AECOPD and COPD groups, with a significant difference in comparison, while there was no difference in CaNO. Multiple regression analysis showed that smoking and ICS were the main factors affecting FeNO50, FeNO200, and JawNO of COPD patients.ConclusionThe CaNO levels in patients with AECOPD were significantly elevated compared to those with stable COPD and healthy controls. Smoking and the use of ICS were identified as key influencing factors for both FeNO50, FeNO200, and JawNO. Preliminary observations suggest that BMI and height might exert potential influences on eNO levels in COPD patients, although further investigations are required to confirm these relationships. |
| format | Article |
| id | doaj-art-4b8cdebe7f134fa0a475d295d2958665 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-4b8cdebe7f134fa0a475d295d29586652025-08-20T03:33:07ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16119471611947Analysis of exhaled nitric oxide and its influencing factors in patients with chronic obstructive pulmonary diseaseYa Shen0Li-Li Yang1Guo-Lan Ning2Xiao-Bao Teng3Jing-Feng Shi4Shun-Shun Cui5Zi-Xiao Cao6Yan-Bei Zhang7Ming-Feng Han8Department of Respiratory and Critical Care Medicine, Fuyang Infectious Disease Clinical College of Anhui Medical University, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Fuyang Infectious Disease Clinical College of Anhui Medical University, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Fuyang Infectious Disease Clinical College of Anhui Medical University, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Fuyang Infectious Disease Clinical College of Anhui Medical University, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Fuyang Infectious Disease Clinical College of Anhui Medical University, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Fuyang People’s Hospital, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Fuyang Infectious Disease Clinical College of Anhui Medical University, Fuyang, Anhui, ChinaGeriatric Respiratory and Critical Care, Anhui Geriatric Institute, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Fuyang Infectious Disease Clinical College of Anhui Medical University, Fuyang, Anhui, ChinaObjectivesTo compare exhaled nitric oxide (eNO) levels between patients with chronic obstructive pulmonary disease (COPD) and healthy controls, and to investigate factors influencing eNO measurements.MethodsThe study included 115 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), 89 patients with stable COPD, and 70 healthy medical checkups, and the basic data and eNO of the three groups were collected.ResultsConcentration of alveolar Nitric Oxide (CaNO) was higher in the AECOPD group than in the COPD and healthy control groups, nitric oxide concentration in exhaled breath at a flow rate of 200 ml/s (FeNO200) was higher in the AECOPD group than in the healthy control group, and the difference was significant. In the AECOPD group, non-smokers and ex-smokers had higher nitric oxide concentration in exhaled breath at a flow rate of 50 ml/s (FeNO50) and joint analysis of washout nitric oxide (JawNO) than current smokers. In the healthy control group, FeNO50 was higher in non-smokers and ex-smokers than in current-smokers, and JawNO was higher in non-smokers than in current-smokers. In the AECOPD group, non-smokers also had higher FeNO200 than current smokers, there was no difference in the comparison of CaNO for different smoking states in the three groups. In the COPD group, BMI was negatively correlated with FeNO50, FeNO200, and CaNO; height was positively correlated with FeNO200 and CaNO. Patients who inhaled Corticosteroids (ICS) had lower FeNO50, FeNO200, and JawNO than patients who did not inhale ICS in the AECOPD and COPD groups, with a significant difference in comparison, while there was no difference in CaNO. Multiple regression analysis showed that smoking and ICS were the main factors affecting FeNO50, FeNO200, and JawNO of COPD patients.ConclusionThe CaNO levels in patients with AECOPD were significantly elevated compared to those with stable COPD and healthy controls. Smoking and the use of ICS were identified as key influencing factors for both FeNO50, FeNO200, and JawNO. Preliminary observations suggest that BMI and height might exert potential influences on eNO levels in COPD patients, although further investigations are required to confirm these relationships.https://www.frontiersin.org/articles/10.3389/fmed.2025.1611947/fullexhaled nitric oxideacute exacerbationchronic obstructive pulmonary diseasefactorsinhaled corticosteroid |
| spellingShingle | Ya Shen Li-Li Yang Guo-Lan Ning Xiao-Bao Teng Jing-Feng Shi Shun-Shun Cui Zi-Xiao Cao Yan-Bei Zhang Ming-Feng Han Analysis of exhaled nitric oxide and its influencing factors in patients with chronic obstructive pulmonary disease Frontiers in Medicine exhaled nitric oxide acute exacerbation chronic obstructive pulmonary disease factors inhaled corticosteroid |
| title | Analysis of exhaled nitric oxide and its influencing factors in patients with chronic obstructive pulmonary disease |
| title_full | Analysis of exhaled nitric oxide and its influencing factors in patients with chronic obstructive pulmonary disease |
| title_fullStr | Analysis of exhaled nitric oxide and its influencing factors in patients with chronic obstructive pulmonary disease |
| title_full_unstemmed | Analysis of exhaled nitric oxide and its influencing factors in patients with chronic obstructive pulmonary disease |
| title_short | Analysis of exhaled nitric oxide and its influencing factors in patients with chronic obstructive pulmonary disease |
| title_sort | analysis of exhaled nitric oxide and its influencing factors in patients with chronic obstructive pulmonary disease |
| topic | exhaled nitric oxide acute exacerbation chronic obstructive pulmonary disease factors inhaled corticosteroid |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1611947/full |
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