A central vein sign in the magnetic resonance diagnosing of multiple sclerosis
Background. Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease, which is characterized by the inevitable disability of patients in the long term, which determines the relevance of this problem. Currently, active improvements are being made in the methods of diagnosing multiple scl...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Private institution educational organization of higher education "Medical University "ReaViz"
2024-06-01
|
| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| Subjects: | |
| Online Access: | https://vestnik.reaviz.ru/jour/article/view/934 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849244990076616704 |
|---|---|
| author | E. A. Potemkina I. A. Turchinskay A. Yu. Efimtsev A. G. Trufanov G. N. Bisaga A. Yu. Polushin V. V. Volgina |
| author_facet | E. A. Potemkina I. A. Turchinskay A. Yu. Efimtsev A. G. Trufanov G. N. Bisaga A. Yu. Polushin V. V. Volgina |
| author_sort | E. A. Potemkina |
| collection | DOAJ |
| description | Background. Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease, which is characterized by the inevitable disability of patients in the long term, which determines the relevance of this problem. Currently, active improvements are being made in the methods of diagnosing multiple sclerosis, which include the use of the central vein sign in magnetic resonance imaging (MRI) as a neuroimaging biomarker of MS with high sensitivity and specificity.Aim of study. Determination of the possibility of assessing the central vein sign (CVS) according to MRI data as a potential diagnostic biomarker of MS.Object and methods. An open single-center prospective study of brain MR data was conducted in 55 patients with a verified diagnosis of MS (EDSS 1.0-6.5) aged 19 to 72 years. MR-images were obtained on a tomograph with a magnetic field induction force of 3.0 T. Patients underwent MRI of the brain according to the standard protocol: T2-VI, FLAIR, T1-VI (before and after administration of contrast agent), SWI. A comprehensive statistical analysis and evaluation of the obtained MRI data was performed using the Statistica 12 program.Result. During the evaluation of MR-tomograms, all patients with a verified diagnosis in the foci of MS were found to have CVS. In 14.5 % of patients, CVS was detected in 10-30 % of foci, in 61.8 % of patients in 30-60 %, in 23.6 % of patients, from 60 to 95 % was detected. Accordingly, 52.7 % of patients overcame the threshold value of 45 % required for the differential diagnosis of MS from other conditions.Conclusion. The use of CVS in MRI helps to solve the problem of differential diagnosis of MS from other demyelinating diseases when using its threshold criterion – the percentage of foci containing central veins. |
| format | Article |
| id | doaj-art-4b8c2a436bea40809f3e6b510d9edfb3 |
| institution | Kabale University |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| publishDate | 2024-06-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj-art-4b8c2a436bea40809f3e6b510d9edfb32025-08-20T03:58:59ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792024-06-0114212313010.20340/vmi-rvz.2024.2.MIM.2583A central vein sign in the magnetic resonance diagnosing of multiple sclerosisE. A. Potemkina0I. A. Turchinskay1A. Yu. Efimtsev2A. G. Trufanov3G. N. Bisaga4A. Yu. Polushin5V. V. Volgina6V.A. Almazov National Medical Research CenterV.A. Almazov National Medical Research CenterV.A. Almazov National Medical Research Center; Personalized Medicine CenterFirst St. Petersburg State Medical University named after Academician I.P. PavlovV.A. Almazov National Medical Research CenterFirst St. Petersburg State Medical University named after Academician I.P. PavlovV.A. Almazov National Medical Research CenterBackground. Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease, which is characterized by the inevitable disability of patients in the long term, which determines the relevance of this problem. Currently, active improvements are being made in the methods of diagnosing multiple sclerosis, which include the use of the central vein sign in magnetic resonance imaging (MRI) as a neuroimaging biomarker of MS with high sensitivity and specificity.Aim of study. Determination of the possibility of assessing the central vein sign (CVS) according to MRI data as a potential diagnostic biomarker of MS.Object and methods. An open single-center prospective study of brain MR data was conducted in 55 patients with a verified diagnosis of MS (EDSS 1.0-6.5) aged 19 to 72 years. MR-images were obtained on a tomograph with a magnetic field induction force of 3.0 T. Patients underwent MRI of the brain according to the standard protocol: T2-VI, FLAIR, T1-VI (before and after administration of contrast agent), SWI. A comprehensive statistical analysis and evaluation of the obtained MRI data was performed using the Statistica 12 program.Result. During the evaluation of MR-tomograms, all patients with a verified diagnosis in the foci of MS were found to have CVS. In 14.5 % of patients, CVS was detected in 10-30 % of foci, in 61.8 % of patients in 30-60 %, in 23.6 % of patients, from 60 to 95 % was detected. Accordingly, 52.7 % of patients overcame the threshold value of 45 % required for the differential diagnosis of MS from other conditions.Conclusion. The use of CVS in MRI helps to solve the problem of differential diagnosis of MS from other demyelinating diseases when using its threshold criterion – the percentage of foci containing central veins.https://vestnik.reaviz.ru/jour/article/view/934magnetic resonance imagingcentral vein sign, multiple sclerosisflairswi |
| spellingShingle | E. A. Potemkina I. A. Turchinskay A. Yu. Efimtsev A. G. Trufanov G. N. Bisaga A. Yu. Polushin V. V. Volgina A central vein sign in the magnetic resonance diagnosing of multiple sclerosis Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье magnetic resonance imaging central vein sign , multiple sclerosis flair swi |
| title | A central vein sign in the magnetic resonance diagnosing of multiple sclerosis |
| title_full | A central vein sign in the magnetic resonance diagnosing of multiple sclerosis |
| title_fullStr | A central vein sign in the magnetic resonance diagnosing of multiple sclerosis |
| title_full_unstemmed | A central vein sign in the magnetic resonance diagnosing of multiple sclerosis |
| title_short | A central vein sign in the magnetic resonance diagnosing of multiple sclerosis |
| title_sort | central vein sign in the magnetic resonance diagnosing of multiple sclerosis |
| topic | magnetic resonance imaging central vein sign , multiple sclerosis flair swi |
| url | https://vestnik.reaviz.ru/jour/article/view/934 |
| work_keys_str_mv | AT eapotemkina acentralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT iaturchinskay acentralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT ayuefimtsev acentralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT agtrufanov acentralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT gnbisaga acentralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT ayupolushin acentralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT vvvolgina acentralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT eapotemkina centralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT iaturchinskay centralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT ayuefimtsev centralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT agtrufanov centralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT gnbisaga centralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT ayupolushin centralveinsigninthemagneticresonancediagnosingofmultiplesclerosis AT vvvolgina centralveinsigninthemagneticresonancediagnosingofmultiplesclerosis |