Risk of Potentially Neurotoxic Exposure in Infants Under High-Dose Cefepime Treatment—A Pharmacometric Simulation Study

Risk of Potentially Neurotoxic Exposure in Infants Under High-Dose Cefepime Treatment—A Pharmacometric Simulation Study

<b>Background:</b> Optimal dosing of cefepime in infants 1–2 months remains undefined. <b>Objectives</b>: We aimed to quantify the risk of potentially neurotoxic exposure with high-dose cefepime (50 mg/kg/8 h) in infants 1–2 months of age, as compared to adjacent age groups (...

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Bibliographic Details
Main Authors: Verena Gotta, Chantal Csajka, Antonia Glauser, Christoph Berger, Marc Pfister, Paolo Paioni
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceutics
Subjects:
cefepime
neurotoxicity
infants
neonates
children
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/17/5/544
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