Selenium - its role in physiology and endocrinology and as organoselenium compounds in oncology: A minireview
The present minireview traces the road leading to discovery of selenium, formerly appointed as a toxic element that became later a bioelement, which is necessary for the proper functioning of living organisms. Selenium occurs in human and animal bodies either in the form of seleno-Lcysteine or its d...
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Sciendo
2024-01-01
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| Series: | Endocrine Regulations |
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| Online Access: | https://doi.org/10.2478/enr-2024-0028 |
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| author | Brtko Julius Podoba Jan Macejova Dana |
| author_facet | Brtko Julius Podoba Jan Macejova Dana |
| author_sort | Brtko Julius |
| collection | DOAJ |
| description | The present minireview traces the road leading to discovery of selenium, formerly appointed as a toxic element that became later a bioelement, which is necessary for the proper functioning of living organisms. Selenium occurs in human and animal bodies either in the form of seleno-Lcysteine or its dimeric form seleno-L-cystine as a crucial component of selenoenzymes or selenoproteins. Selenium atom represents an integral component of the enzyme active site of different forms of glutathione peroxidase, which catalyzes conversion of hydrogen peroxide and organic hydroperoxides into the water and corresponding alcohols. A revolutionary breakthrough in the field of endocrinology came with the identification of different forms of iodothyronine deiodinase as selenoenzymes, which play an important role in the metabolism of thyroid hormone. The role of selenium in immune function and autoimmune thyropathies that might be associated with selenium deficiency are reported and discussed. This minireview also brings forward novel directions of organoselenium compounds or selenium nanoparticles in cancer therapy. Based on the update of available literature and the author’s experimental experience, the minireview can be devoted to clinicians and medical students. |
| format | Article |
| id | doaj-art-4b855d9bc5cf48078df5dc1a94d26bc2 |
| institution | OA Journals |
| issn | 1336-0329 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Endocrine Regulations |
| spelling | doaj-art-4b855d9bc5cf48078df5dc1a94d26bc22025-08-20T01:53:33ZengSciendoEndocrine Regulations1336-03292024-01-0158123324110.2478/enr-2024-0028Selenium - its role in physiology and endocrinology and as organoselenium compounds in oncology: A minireviewBrtko Julius0Podoba Jan1Macejova Dana2Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaDepartment of Endocrinology, Slovak Medical University and St. Elisabeth Institute of Oncology, Bratislava, SlovakiaInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaThe present minireview traces the road leading to discovery of selenium, formerly appointed as a toxic element that became later a bioelement, which is necessary for the proper functioning of living organisms. Selenium occurs in human and animal bodies either in the form of seleno-Lcysteine or its dimeric form seleno-L-cystine as a crucial component of selenoenzymes or selenoproteins. Selenium atom represents an integral component of the enzyme active site of different forms of glutathione peroxidase, which catalyzes conversion of hydrogen peroxide and organic hydroperoxides into the water and corresponding alcohols. A revolutionary breakthrough in the field of endocrinology came with the identification of different forms of iodothyronine deiodinase as selenoenzymes, which play an important role in the metabolism of thyroid hormone. The role of selenium in immune function and autoimmune thyropathies that might be associated with selenium deficiency are reported and discussed. This minireview also brings forward novel directions of organoselenium compounds or selenium nanoparticles in cancer therapy. Based on the update of available literature and the author’s experimental experience, the minireview can be devoted to clinicians and medical students.https://doi.org/10.2478/enr-2024-0028seleniumorganoselenium compoundsselenium nanoparticlesselenoenzymesselenoproteinsthyroid hormoneimmune functionautoimmune thyropathiescancer |
| spellingShingle | Brtko Julius Podoba Jan Macejova Dana Selenium - its role in physiology and endocrinology and as organoselenium compounds in oncology: A minireview Endocrine Regulations selenium organoselenium compounds selenium nanoparticles selenoenzymes selenoproteins thyroid hormone immune function autoimmune thyropathies cancer |
| title | Selenium - its role in physiology and endocrinology and as organoselenium compounds in oncology: A minireview |
| title_full | Selenium - its role in physiology and endocrinology and as organoselenium compounds in oncology: A minireview |
| title_fullStr | Selenium - its role in physiology and endocrinology and as organoselenium compounds in oncology: A minireview |
| title_full_unstemmed | Selenium - its role in physiology and endocrinology and as organoselenium compounds in oncology: A minireview |
| title_short | Selenium - its role in physiology and endocrinology and as organoselenium compounds in oncology: A minireview |
| title_sort | selenium its role in physiology and endocrinology and as organoselenium compounds in oncology a minireview |
| topic | selenium organoselenium compounds selenium nanoparticles selenoenzymes selenoproteins thyroid hormone immune function autoimmune thyropathies cancer |
| url | https://doi.org/10.2478/enr-2024-0028 |
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