Multicomponent synthesis of α-branched amines using organozinc reagents generated from alkyl bromides

Multicomponent synthesis of α-branched amines using organozinc reagents generated from alkyl bromides

The use of alkylzinc bromides in the multicomponent Mannich reaction is described. Heteroleptic organozinc compounds were obtained in THF or 2-MeTHF by direct insertion of zinc dust into the C–Br bond of alkyl bromides. It was found that the presence of a stoichiometric amount of LiCl was essential...

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Bibliographic Details
Main Authors: Baptiste Leroux, Alexis Beaufils, Federico Banchini, Olivier Jackowski, Alejandro Perez-Luna, Fabrice Chemla, Marc Presset, Erwan Le Gall
Format: Article
Language:English
Published: Beilstein-Institut 2024-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
alkyl bromides
branched amines
mannich reaction
multicomponent reaction
zinc
Online Access:https://doi.org/10.3762/bjoc.20.239
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