Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis
A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the casc...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/6716419 |
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| author | K. Juczynska A. Wozniacka E. Waszczykowska M. Danilewicz M. Wagrowska-Danilewicz J. Wieczfinska R. Pawliczak A. Zebrowska |
| author_facet | K. Juczynska A. Wozniacka E. Waszczykowska M. Danilewicz M. Wagrowska-Danilewicz J. Wieczfinska R. Pawliczak A. Zebrowska |
| author_sort | K. Juczynska |
| collection | DOAJ |
| description | A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the cascade may contribute to pathogenesis of autoimmune diseases; however, there are no reports concerning autoimmune bullous diseases yet to be published. The aim of this study was to evaluate the expression of proteins constituting the JAK/STAT signaling pathway in skin lesions and perilesional area in dermatitis herpetiformis (DH) and bullous pemphigoid (BP), as well as in the control group. Skin biopsies were collected from 21 DH patients, from 20 BP patients, and from 10 healthy volunteers. The localization and expression of selected STAT and JAK proteins were examined by immunohistochemistry and immunoblotting. We found significantly higher expression of JAK/STAT proteins in skin lesions in patients with BP and DH, in comparison to perilesional skin and the control group, which may be related to proinflammatory cytokine network and induction of inflammatory infiltrate in tissues. Our findings suggest that differences in the JAK and STAT expression may be related to distinct cytokines activating them and mediating neutrophilic and/or eosinophilic infiltrate. |
| format | Article |
| id | doaj-art-4b7ae40f559549cc83b4befe43de361a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4b7ae40f559549cc83b4befe43de361a2025-02-03T05:47:16ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/67164196716419Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis HerpetiformisK. Juczynska0A. Wozniacka1E. Waszczykowska2M. Danilewicz3M. Wagrowska-Danilewicz4J. Wieczfinska5R. Pawliczak6A. Zebrowska7Department of Dermatology and Venereology, Medical University of Lodz, Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Lodz, PolandDepartment of Pathomorphology, Medical University of Lodz, Lodz, PolandDepartment of Nephropathology, Medical University of Lodz, Lodz, PolandDepartment of Immunopathology, Chair of Allergy, Immunology and Dermatology, Medical University of Lodz, Lodz, PolandDepartment of Immunopathology, Chair of Allergy, Immunology and Dermatology, Medical University of Lodz, Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Lodz, PolandA family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the cascade may contribute to pathogenesis of autoimmune diseases; however, there are no reports concerning autoimmune bullous diseases yet to be published. The aim of this study was to evaluate the expression of proteins constituting the JAK/STAT signaling pathway in skin lesions and perilesional area in dermatitis herpetiformis (DH) and bullous pemphigoid (BP), as well as in the control group. Skin biopsies were collected from 21 DH patients, from 20 BP patients, and from 10 healthy volunteers. The localization and expression of selected STAT and JAK proteins were examined by immunohistochemistry and immunoblotting. We found significantly higher expression of JAK/STAT proteins in skin lesions in patients with BP and DH, in comparison to perilesional skin and the control group, which may be related to proinflammatory cytokine network and induction of inflammatory infiltrate in tissues. Our findings suggest that differences in the JAK and STAT expression may be related to distinct cytokines activating them and mediating neutrophilic and/or eosinophilic infiltrate.http://dx.doi.org/10.1155/2017/6716419 |
| spellingShingle | K. Juczynska A. Wozniacka E. Waszczykowska M. Danilewicz M. Wagrowska-Danilewicz J. Wieczfinska R. Pawliczak A. Zebrowska Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis Mediators of Inflammation |
| title | Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis |
| title_full | Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis |
| title_fullStr | Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis |
| title_full_unstemmed | Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis |
| title_short | Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis |
| title_sort | expression of the jak stat signaling pathway in bullous pemphigoid and dermatitis herpetiformis |
| url | http://dx.doi.org/10.1155/2017/6716419 |
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