Methotrexate in Rheumatoid Arthritis: Effect on Blood, Liver and Renal Laboratory Parameters
Objective: To evaluate the effect of Methotrexate on blood, liver and renal laboratory parameters in patients having rheumatoid arthritis. Materials and Methods : A 24-week, single-blind, interventional study was carried out on 155 consecutive patients, aged 29- 70 years, diagnosed with rheumatoid...
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| Format: | Article |
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Bahria Univerisy Health Sciences, Campus Karachi
2015-12-01
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| Series: | Journal of Bahria University Medical and Dental College |
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| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/141 |
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| author | Fuad Shaikh Rabia Arshad Fahad Azam Nasim Karim |
| author_facet | Fuad Shaikh Rabia Arshad Fahad Azam Nasim Karim |
| author_sort | Fuad Shaikh |
| collection | DOAJ |
| description |
Objective: To evaluate the effect of Methotrexate on blood, liver and renal laboratory parameters in patients having rheumatoid
arthritis.
Materials and Methods : A 24-week, single-blind, interventional study was carried out on 155 consecutive patients, aged 29-
70 years, diagnosed with rheumatoid arthritis. They received tablet Methotrexate, 10 mg (2.5 mg, 4 tablets) weekly, orally.
Laboratory tests like hemoglobin level, total white cell and platelet counts, erythrocyte sedimentation rate, serum glutamic
pyruvic transaminase and serum creatinine levels were recorded at the initial visit as well as at 6, 14 and 24 weeks follow-up
visits.
Results: At the end of 24 weeks hemoglobin level increased to 12.43 ± 0.92 grams per deciliter (g/dl) from a baseline of 10.76
± 1.12 g/dl, white cell count fell to 7,142.46 ± 1332.23 per cubic mm (cmm) from 8,572 ± 1445/cmm, the ESR fell to 40.14
±15.78 mm of Hg in 1st hour from 81.03 ±17.98 mm of Hg, the platelet count fell to 2, 33,738.10 ± 59,769/ cmm from 2, 90,278
± 68,813/cmm, the SGPT levels increased to 55.29 ± 21.97 international units per litre (IU/l) from 31.67 ± 7.37 IU/l and the
serum creatinine increased to 1.11 ± 0.14 mg/dl from 0.95 ± 0.16 mg/dl, all values being highly significant statistically (p<0.001).
Conclusion: Methotrexate exerted significant effects on the blood, liver and renal laboratory parameters. These parameters
may be utilized for monitoring the response and safety of methotrexate use in RA.
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| format | Article |
| id | doaj-art-4b7a22e4d2ea45f9a3bba6e6fddab2ee |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-4b7a22e4d2ea45f9a3bba6e6fddab2ee2025-08-20T03:10:49ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822015-12-0154Methotrexate in Rheumatoid Arthritis: Effect on Blood, Liver and Renal Laboratory ParametersFuad ShaikhRabia ArshadFahad AzamNasim Karim Objective: To evaluate the effect of Methotrexate on blood, liver and renal laboratory parameters in patients having rheumatoid arthritis. Materials and Methods : A 24-week, single-blind, interventional study was carried out on 155 consecutive patients, aged 29- 70 years, diagnosed with rheumatoid arthritis. They received tablet Methotrexate, 10 mg (2.5 mg, 4 tablets) weekly, orally. Laboratory tests like hemoglobin level, total white cell and platelet counts, erythrocyte sedimentation rate, serum glutamic pyruvic transaminase and serum creatinine levels were recorded at the initial visit as well as at 6, 14 and 24 weeks follow-up visits. Results: At the end of 24 weeks hemoglobin level increased to 12.43 ± 0.92 grams per deciliter (g/dl) from a baseline of 10.76 ± 1.12 g/dl, white cell count fell to 7,142.46 ± 1332.23 per cubic mm (cmm) from 8,572 ± 1445/cmm, the ESR fell to 40.14 ±15.78 mm of Hg in 1st hour from 81.03 ±17.98 mm of Hg, the platelet count fell to 2, 33,738.10 ± 59,769/ cmm from 2, 90,278 ± 68,813/cmm, the SGPT levels increased to 55.29 ± 21.97 international units per litre (IU/l) from 31.67 ± 7.37 IU/l and the serum creatinine increased to 1.11 ± 0.14 mg/dl from 0.95 ± 0.16 mg/dl, all values being highly significant statistically (p<0.001). Conclusion: Methotrexate exerted significant effects on the blood, liver and renal laboratory parameters. These parameters may be utilized for monitoring the response and safety of methotrexate use in RA. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/141Rheumatoid arthritis, Methotrexate, Laboratory parameters, Monitoring, Response, Drug safety |
| spellingShingle | Fuad Shaikh Rabia Arshad Fahad Azam Nasim Karim Methotrexate in Rheumatoid Arthritis: Effect on Blood, Liver and Renal Laboratory Parameters Journal of Bahria University Medical and Dental College Rheumatoid arthritis, Methotrexate, Laboratory parameters, Monitoring, Response, Drug safety |
| title | Methotrexate in Rheumatoid Arthritis: Effect on Blood, Liver and Renal Laboratory Parameters |
| title_full | Methotrexate in Rheumatoid Arthritis: Effect on Blood, Liver and Renal Laboratory Parameters |
| title_fullStr | Methotrexate in Rheumatoid Arthritis: Effect on Blood, Liver and Renal Laboratory Parameters |
| title_full_unstemmed | Methotrexate in Rheumatoid Arthritis: Effect on Blood, Liver and Renal Laboratory Parameters |
| title_short | Methotrexate in Rheumatoid Arthritis: Effect on Blood, Liver and Renal Laboratory Parameters |
| title_sort | methotrexate in rheumatoid arthritis effect on blood liver and renal laboratory parameters |
| topic | Rheumatoid arthritis, Methotrexate, Laboratory parameters, Monitoring, Response, Drug safety |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/141 |
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