Local and Distributed fMRI Changes Induced by 40 Hz Gamma tACS of the Bilateral Dorsolateral Prefrontal Cortex: A Pilot Study
Over the past few years, the possibility of modulating fast brain oscillatory activity in the gamma (γ) band through transcranial alternating current stimulation (tACS) has been discussed in the context of both cognitive enhancement and therapeutic scenarios. However, the effects of tACS targeting r...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2022/6197505 |
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| author | Lucia Mencarelli Lucia Monti Sara Romanella Francesco Neri Giacomo Koch Ricardo Salvador Giulio Ruffini Giulia Sprugnoli Simone Rossi Emiliano Santarnecchi |
| author_facet | Lucia Mencarelli Lucia Monti Sara Romanella Francesco Neri Giacomo Koch Ricardo Salvador Giulio Ruffini Giulia Sprugnoli Simone Rossi Emiliano Santarnecchi |
| author_sort | Lucia Mencarelli |
| collection | DOAJ |
| description | Over the past few years, the possibility of modulating fast brain oscillatory activity in the gamma (γ) band through transcranial alternating current stimulation (tACS) has been discussed in the context of both cognitive enhancement and therapeutic scenarios. However, the effects of tACS targeting regions outside the motor cortex, as well as its spatial specificity, are still unclear. Here, we present a concurrent tACS-fMRI block design study to characterize the impact of 40 Hz tACS applied over the left and right dorsolateral prefrontal cortex (DLPFC) in healthy subjects. Results suggest an increase in blood oxygenation level-dependent (BOLD) activity in the targeted bilateral DLPFCs, as well as in surrounding brain areas affected by stimulation according to biophysical modeling, i.e., the premotor cortex and anterior cingulate cortex (ACC). However, off-target effects were also observed, primarily involving the visual cortices, with further effects on the supplementary motor areas (SMA), left subgenual cingulate, and right superior temporal gyrus. The specificity of 40 Hz tACS over bilateral DLPFC and the possibility for network-level effects should be considered in future studies, especially in the context of recently promoted gamma-induction therapeutic protocols for neurodegenerative disorders. |
| format | Article |
| id | doaj-art-4b779d668e77414b8328493da29afc11 |
| institution | Kabale University |
| issn | 1687-5443 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-4b779d668e77414b8328493da29afc112025-02-03T06:04:49ZengWileyNeural Plasticity1687-54432022-01-01202210.1155/2022/6197505Local and Distributed fMRI Changes Induced by 40 Hz Gamma tACS of the Bilateral Dorsolateral Prefrontal Cortex: A Pilot StudyLucia Mencarelli0Lucia Monti1Sara Romanella2Francesco Neri3Giacomo Koch4Ricardo Salvador5Giulio Ruffini6Giulia Sprugnoli7Simone Rossi8Emiliano Santarnecchi9Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab)Unit of Neuroimaging and NeurointerventionSiena Brain Investigation & Neuromodulation Lab (Si-BIN Lab)Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab)Non-invasive Brain Stimulation UnitNeuroelectricsNeuroelectricsSiena Brain Investigation & Neuromodulation Lab (Si-BIN Lab)Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab)Precision Neuromodulation Program & Network Control LaboratoryOver the past few years, the possibility of modulating fast brain oscillatory activity in the gamma (γ) band through transcranial alternating current stimulation (tACS) has been discussed in the context of both cognitive enhancement and therapeutic scenarios. However, the effects of tACS targeting regions outside the motor cortex, as well as its spatial specificity, are still unclear. Here, we present a concurrent tACS-fMRI block design study to characterize the impact of 40 Hz tACS applied over the left and right dorsolateral prefrontal cortex (DLPFC) in healthy subjects. Results suggest an increase in blood oxygenation level-dependent (BOLD) activity in the targeted bilateral DLPFCs, as well as in surrounding brain areas affected by stimulation according to biophysical modeling, i.e., the premotor cortex and anterior cingulate cortex (ACC). However, off-target effects were also observed, primarily involving the visual cortices, with further effects on the supplementary motor areas (SMA), left subgenual cingulate, and right superior temporal gyrus. The specificity of 40 Hz tACS over bilateral DLPFC and the possibility for network-level effects should be considered in future studies, especially in the context of recently promoted gamma-induction therapeutic protocols for neurodegenerative disorders.http://dx.doi.org/10.1155/2022/6197505 |
| spellingShingle | Lucia Mencarelli Lucia Monti Sara Romanella Francesco Neri Giacomo Koch Ricardo Salvador Giulio Ruffini Giulia Sprugnoli Simone Rossi Emiliano Santarnecchi Local and Distributed fMRI Changes Induced by 40 Hz Gamma tACS of the Bilateral Dorsolateral Prefrontal Cortex: A Pilot Study Neural Plasticity |
| title | Local and Distributed fMRI Changes Induced by 40 Hz Gamma tACS of the Bilateral Dorsolateral Prefrontal Cortex: A Pilot Study |
| title_full | Local and Distributed fMRI Changes Induced by 40 Hz Gamma tACS of the Bilateral Dorsolateral Prefrontal Cortex: A Pilot Study |
| title_fullStr | Local and Distributed fMRI Changes Induced by 40 Hz Gamma tACS of the Bilateral Dorsolateral Prefrontal Cortex: A Pilot Study |
| title_full_unstemmed | Local and Distributed fMRI Changes Induced by 40 Hz Gamma tACS of the Bilateral Dorsolateral Prefrontal Cortex: A Pilot Study |
| title_short | Local and Distributed fMRI Changes Induced by 40 Hz Gamma tACS of the Bilateral Dorsolateral Prefrontal Cortex: A Pilot Study |
| title_sort | local and distributed fmri changes induced by 40 hz gamma tacs of the bilateral dorsolateral prefrontal cortex a pilot study |
| url | http://dx.doi.org/10.1155/2022/6197505 |
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