Endobronchial tuberculosis mimicking malignancy: Lessons from a case report

Endobronchial tuberculosis is characterized by the presence of tuberculous lesions within the bronchi, irrespective of the formation of pulmonary lesions. When these lesions are visible, their morphology often raises the differential diagnosis of malignancy. Diagnostic challenges arise as sputum sme...

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Main Authors: Tomohito Okano, Hajime Fujimoto, Toshiyuki Ito, Atsushi Tomaru, Haruko Saiki, Tatsuki Tsuruga, Taro Yasuma, Corina N. D'Alessandro-Gabazza, Esteban C. Gabazza, Tetsu Kobayashi
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Respiratory Medicine Case Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213007125000371
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Summary:Endobronchial tuberculosis is characterized by the presence of tuberculous lesions within the bronchi, irrespective of the formation of pulmonary lesions. When these lesions are visible, their morphology often raises the differential diagnosis of malignancy. Diagnostic challenges arise as sputum smear tests—crucial for mycobacterial identification—may yield negative results in up to half of the cases. Here, we present a 66-year-old male who exhibited clinical and radiological findings suggestive of malignancy but was ultimately diagnosed with endobronchial tuberculosis through a combination of bronchoscopy, histopathology, and polymerase chain reaction testing. The patient responded favorably to anti-tuberculosis therapy. This case underscores the importance of comprehensive diagnostic strategies for endobronchial tuberculosis, particularly in distinguishing it from tracheal malignancies.
ISSN:2213-0071