Negative Epistasis between Sickle and Foetal Haemoglobin Suggests a Reduction in Protection against Malaria.

Negative Epistasis between Sickle and Foetal Haemoglobin Suggests a Reduction in Protection against Malaria.

<h4>Background</h4>Haemoglobin variants, Sickle (HbS) and foetal (HbF) have been associated with malaria protection. This study explores epistatic interactions between HbS and HbF on malaria infection.<h4>Methods</h4>The study was conducted between March 2004 and December 201...

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Main Authors: Bruno P Mmbando, Josephine Mgaya, Sharon E Cox, Siana N Mtatiro, Deogratias Soka, Stella Rwezaula, Elineema Meda, Evarist Msaki, Robert W Snow, Neal Jeffries, Nancy L Geller, Julie Makani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0125929
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