Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer
Abstract Intravesical photodynamic therapy (PDT) emerges as a promising modality for bladder cancer treatment, yet its efficacy is often curtailed by weak muco-adhesion, poor muco-penetration, low tumor-targeting and intra-tumoral oxygen scarcity. In this work, we introduce a drug delivery system le...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03594-6 |
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| author | Yang Liu Wentao Xu Xiaowen Qin Jiajia Zheng Bin Zheng Li Sun Wenyan Zuo Dingyi Liu Zhenghong Liu Yixuan Mou Heng Wang Qi Zhang Jun Chen Pu Zhang Dahong Zhang |
| author_facet | Yang Liu Wentao Xu Xiaowen Qin Jiajia Zheng Bin Zheng Li Sun Wenyan Zuo Dingyi Liu Zhenghong Liu Yixuan Mou Heng Wang Qi Zhang Jun Chen Pu Zhang Dahong Zhang |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Abstract Intravesical photodynamic therapy (PDT) emerges as a promising modality for bladder cancer treatment, yet its efficacy is often curtailed by weak muco-adhesion, poor muco-penetration, low tumor-targeting and intra-tumoral oxygen scarcity. In this work, we introduce a drug delivery system leveraging cerium oxide (CeO2) nanozymes as the core, polyarginine peptides R11 as the tumor-targeting ligands, and indocyanine green (ICG) as the photosensitizers, with the latter two components assembled on the particle surface. Intravesical ICG@R11-CeO2 nanoparticles displayed enhanced mucoadhesive, mucus-penetrating and tumor-targeting properties, and effectively mitigated the hypoxia threat in the tumor microenvironment to improve the PDT sensitivity. Remarkably, the intravesical PDT via ICG@R11-CeO2 nanoparticles achieved complete tumor inhibition in orthotopic bladder cancer models, offering strong evidence on its clinical translational potential. |
| format | Article |
| id | doaj-art-4b70d65b97394e2e99a2680f94c15db0 |
| institution | DOAJ |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-4b70d65b97394e2e99a2680f94c15db02025-08-20T03:06:04ZengBMCJournal of Nanobiotechnology1477-31552025-08-0123111410.1186/s12951-025-03594-6Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancerYang Liu0Wentao Xu1Xiaowen Qin2Jiajia Zheng3Bin Zheng4Li Sun5Wenyan Zuo6Dingyi Liu7Zhenghong Liu8Yixuan Mou9Heng Wang10Qi Zhang11Jun Chen12Pu Zhang13Dahong Zhang14Suzhou Medical College of Soochow UniversityCancer Center, Department of Interventional Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeCancer Center, Department of Interventional Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeCancer Center, Department of Interventional Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeSuzhou Medical College of Soochow UniversityAbstract Intravesical photodynamic therapy (PDT) emerges as a promising modality for bladder cancer treatment, yet its efficacy is often curtailed by weak muco-adhesion, poor muco-penetration, low tumor-targeting and intra-tumoral oxygen scarcity. In this work, we introduce a drug delivery system leveraging cerium oxide (CeO2) nanozymes as the core, polyarginine peptides R11 as the tumor-targeting ligands, and indocyanine green (ICG) as the photosensitizers, with the latter two components assembled on the particle surface. Intravesical ICG@R11-CeO2 nanoparticles displayed enhanced mucoadhesive, mucus-penetrating and tumor-targeting properties, and effectively mitigated the hypoxia threat in the tumor microenvironment to improve the PDT sensitivity. Remarkably, the intravesical PDT via ICG@R11-CeO2 nanoparticles achieved complete tumor inhibition in orthotopic bladder cancer models, offering strong evidence on its clinical translational potential.https://doi.org/10.1186/s12951-025-03594-6Bladder CancerIntravesical therapyNanozymePhotodynamic therapy |
| spellingShingle | Yang Liu Wentao Xu Xiaowen Qin Jiajia Zheng Bin Zheng Li Sun Wenyan Zuo Dingyi Liu Zhenghong Liu Yixuan Mou Heng Wang Qi Zhang Jun Chen Pu Zhang Dahong Zhang Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer Journal of Nanobiotechnology Bladder Cancer Intravesical therapy Nanozyme Photodynamic therapy |
| title | Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer |
| title_full | Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer |
| title_fullStr | Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer |
| title_full_unstemmed | Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer |
| title_short | Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer |
| title_sort | intravesical delivery of mucoadhesive and tumor selective penetrating nanozymes for enhancing the pdt of bladder cancer |
| topic | Bladder Cancer Intravesical therapy Nanozyme Photodynamic therapy |
| url | https://doi.org/10.1186/s12951-025-03594-6 |
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