A rare case of Klippel-Trenaunay syndrome presenting with chronic myeloid leukemia
Background. Klippel-Trenaunay syndrome (KTS) is an overgrowth syndrome associated with capillary/venous/ lymphatic malformations with limb hypertrophy and cancer risk. Various cancers, mostly Wilms tumor, have been reported in patients with KTS, but not leukemia. Chronic myeloid leukemia (CML...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2023-02-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/14 |
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| author | Çağrı Coşkun Tekin Aksu Fatma Gümrük Şule Ünal |
| author_facet | Çağrı Coşkun Tekin Aksu Fatma Gümrük Şule Ünal |
| author_sort | Çağrı Coşkun |
| collection | DOAJ |
| description |
Background. Klippel-Trenaunay syndrome (KTS) is an overgrowth syndrome associated with capillary/venous/ lymphatic malformations with limb hypertrophy and cancer risk. Various cancers, mostly Wilms tumor, have been reported in patients with KTS, but not leukemia. Chronic myeloid leukemia (CML) is also a rare disease in children, where there is no known disease or syndrome to predispose to CML.
Case. We report a case of CML incidentally diagnosed in a child with KTS when he was bleeding from surgery of the left groin for vascular malformation.
Conclusions. This case reflects the variety of cancer types that may accompany KTS and provides information about CML prognosis in such patients.
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| format | Article |
| id | doaj-art-4b6edf73866e45b2b1d35f0217837ea3 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-4b6edf73866e45b2b1d35f0217837ea32025-08-20T02:00:55ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212023-02-0165110.24953/turkjped.2022.254A rare case of Klippel-Trenaunay syndrome presenting with chronic myeloid leukemiaÇağrı Coşkun0Tekin Aksu1Fatma Gümrük2Şule Ünal3Department of Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Department of Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Department of Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Department of Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara, Türkiye. Background. Klippel-Trenaunay syndrome (KTS) is an overgrowth syndrome associated with capillary/venous/ lymphatic malformations with limb hypertrophy and cancer risk. Various cancers, mostly Wilms tumor, have been reported in patients with KTS, but not leukemia. Chronic myeloid leukemia (CML) is also a rare disease in children, where there is no known disease or syndrome to predispose to CML. Case. We report a case of CML incidentally diagnosed in a child with KTS when he was bleeding from surgery of the left groin for vascular malformation. Conclusions. This case reflects the variety of cancer types that may accompany KTS and provides information about CML prognosis in such patients. https://turkjpediatr.org/article/view/14CVLM syndromeKlippel-Trenaunay syndromePIK3CA genechronic myeloid leukemiaovergrowth syndromevascular malformation |
| spellingShingle | Çağrı Coşkun Tekin Aksu Fatma Gümrük Şule Ünal A rare case of Klippel-Trenaunay syndrome presenting with chronic myeloid leukemia The Turkish Journal of Pediatrics CVLM syndrome Klippel-Trenaunay syndrome PIK3CA gene chronic myeloid leukemia overgrowth syndrome vascular malformation |
| title | A rare case of Klippel-Trenaunay syndrome presenting with chronic myeloid leukemia |
| title_full | A rare case of Klippel-Trenaunay syndrome presenting with chronic myeloid leukemia |
| title_fullStr | A rare case of Klippel-Trenaunay syndrome presenting with chronic myeloid leukemia |
| title_full_unstemmed | A rare case of Klippel-Trenaunay syndrome presenting with chronic myeloid leukemia |
| title_short | A rare case of Klippel-Trenaunay syndrome presenting with chronic myeloid leukemia |
| title_sort | rare case of klippel trenaunay syndrome presenting with chronic myeloid leukemia |
| topic | CVLM syndrome Klippel-Trenaunay syndrome PIK3CA gene chronic myeloid leukemia overgrowth syndrome vascular malformation |
| url | https://turkjpediatr.org/article/view/14 |
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