Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signaling

Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signaling

Abstract Background Angiogenesis and osteogenesis are closely interrelated. The interaction between endothelial and bone-forming cells, such as osteoblasts, is crucial for normal bone development and repair. Juxtacrine and paracrine mechanisms play key roles in cell differentiation towards the osteo...

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Main Authors: Daria Perepletchikova, Polina Kuchur, Liubov Basovich, Irina Khvorova, Arseniy Lobov, Kseniia Azarkina, Nikolay Aksenov, Svetlana Bozhkova, Vitaliy Karelkin, Anna Malashicheva
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
Endothelial cells
Osteoblasts
Osteogenic differentiation
Notch signaling
Co-culture
Online Access:https://doi.org/10.1186/s12964-025-02096-0
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