Effects of 1<i>H</i>-1,2,3-Triazole Derivatives of 3-<i>O</i>-Acetyl-11-Keto-Beta-Boswellic Acid from <i>Boswellia sacra</i> Resin on T-Cell Proliferation and Activation
<b>Background:</b> 3-<i>O</i>-acetyl-11-keto-<i>β</i>-boswellic acid (<i>β</i>-AKBA), a triterpene natural product, is one of the main natural products of <i>Boswellia sacra</i> resin (BSR) and has reported biological and immunomodulatory e...
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2024-12-01
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| author | Abdo Meyiah Satya Kumar Avula Ahmed Al-Harrasi Eyad Elkord |
| author_facet | Abdo Meyiah Satya Kumar Avula Ahmed Al-Harrasi Eyad Elkord |
| author_sort | Abdo Meyiah |
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| description | <b>Background:</b> 3-<i>O</i>-acetyl-11-keto-<i>β</i>-boswellic acid (<i>β</i>-AKBA), a triterpene natural product, is one of the main natural products of <i>Boswellia sacra</i> resin (BSR) and has reported biological and immunomodulatory effects. 1<i>H</i>-1,2,3-triazole derivatives of <i>β</i>-AKBA (named <b>6a</b>–<b>6d</b>) were synthesized from <i>β</i>-AKBA. The 1<i>H</i>-1,2,3-triazole compounds are also known to have a wide range of biological and pharmacological properties as demonstrated by in vitro and in vivo studies. This study aimed to investigate the effects of these 1<i>H</i>-1,2,3-triazole derivatives of <i>β</i>-AKBA on human T-cell proliferation and activation. <b>Methods:</b> PBMCs isolated from healthy donors were activated by anti-CD3/CD28 monoclonal antibodies in the presence of <i>β</i>-AKBA (<b>1</b>) or 1<i>H</i>-1,2,3-triazole derivatives of <i>β</i>-AKBA or DMSO controls. <b>Results:</b> We found that similar to the parent compound <i>β</i>-AKBA (<b>1</b>), derivatives <b>6a</b>, <b>6b</b>, and <b>6d</b> significantly inhibited T-cell expansion/proliferation and reduced the levels of CD25 activation marker on CD4<sup>+</sup> and CD8<sup>+</sup> T cells without exerting significant cytotoxic effects on T-cell viability at a concentration of 25 µM. However, compound <b>6c</b> further inhibited T-cell expansion/proliferation and CD25 expression, but had a significant cytotoxic effect on cell viability at similar concentrations of 25 µM. <b>Conclusions:</b> These findings demonstrate the immunoinhibitory effects of <i>β</i>-AKBA (<b>1</b>) and its corresponding triazole derivatives on T-cell proliferation and activation, highlighting the promising therapeutic potential of these compounds in T-cell-mediated diseases. |
| format | Article |
| id | doaj-art-4b5aae82268b49c4b3072fece942da4f |
| institution | OA Journals |
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| publishDate | 2024-12-01 |
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| spelling | doaj-art-4b5aae82268b49c4b3072fece942da4f2025-08-20T02:01:09ZengMDPI AGPharmaceuticals1424-82472024-12-011712165010.3390/ph17121650Effects of 1<i>H</i>-1,2,3-Triazole Derivatives of 3-<i>O</i>-Acetyl-11-Keto-Beta-Boswellic Acid from <i>Boswellia sacra</i> Resin on T-Cell Proliferation and ActivationAbdo Meyiah0Satya Kumar Avula1Ahmed Al-Harrasi2Eyad Elkord3Department of Biosciences and Bioinformatics and Suzhou Municipal Key Laboratory of Biomedical Sciences and Translational Immunology, School of Science, Xi’an Jiaotong-Liverpool University, Suzhou 215123, ChinaNatural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, OmanNatural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, OmanDepartment of Biosciences and Bioinformatics and Suzhou Municipal Key Laboratory of Biomedical Sciences and Translational Immunology, School of Science, Xi’an Jiaotong-Liverpool University, Suzhou 215123, China<b>Background:</b> 3-<i>O</i>-acetyl-11-keto-<i>β</i>-boswellic acid (<i>β</i>-AKBA), a triterpene natural product, is one of the main natural products of <i>Boswellia sacra</i> resin (BSR) and has reported biological and immunomodulatory effects. 1<i>H</i>-1,2,3-triazole derivatives of <i>β</i>-AKBA (named <b>6a</b>–<b>6d</b>) were synthesized from <i>β</i>-AKBA. The 1<i>H</i>-1,2,3-triazole compounds are also known to have a wide range of biological and pharmacological properties as demonstrated by in vitro and in vivo studies. This study aimed to investigate the effects of these 1<i>H</i>-1,2,3-triazole derivatives of <i>β</i>-AKBA on human T-cell proliferation and activation. <b>Methods:</b> PBMCs isolated from healthy donors were activated by anti-CD3/CD28 monoclonal antibodies in the presence of <i>β</i>-AKBA (<b>1</b>) or 1<i>H</i>-1,2,3-triazole derivatives of <i>β</i>-AKBA or DMSO controls. <b>Results:</b> We found that similar to the parent compound <i>β</i>-AKBA (<b>1</b>), derivatives <b>6a</b>, <b>6b</b>, and <b>6d</b> significantly inhibited T-cell expansion/proliferation and reduced the levels of CD25 activation marker on CD4<sup>+</sup> and CD8<sup>+</sup> T cells without exerting significant cytotoxic effects on T-cell viability at a concentration of 25 µM. However, compound <b>6c</b> further inhibited T-cell expansion/proliferation and CD25 expression, but had a significant cytotoxic effect on cell viability at similar concentrations of 25 µM. <b>Conclusions:</b> These findings demonstrate the immunoinhibitory effects of <i>β</i>-AKBA (<b>1</b>) and its corresponding triazole derivatives on T-cell proliferation and activation, highlighting the promising therapeutic potential of these compounds in T-cell-mediated diseases.https://www.mdpi.com/1424-8247/17/12/1650boswellic acidT cellsCD25<i>β</i>-AKBA1<i>H</i>-1,2,3-triazole |
| spellingShingle | Abdo Meyiah Satya Kumar Avula Ahmed Al-Harrasi Eyad Elkord Effects of 1<i>H</i>-1,2,3-Triazole Derivatives of 3-<i>O</i>-Acetyl-11-Keto-Beta-Boswellic Acid from <i>Boswellia sacra</i> Resin on T-Cell Proliferation and Activation Pharmaceuticals boswellic acid T cells CD25 <i>β</i>-AKBA 1<i>H</i>-1,2,3-triazole |
| title | Effects of 1<i>H</i>-1,2,3-Triazole Derivatives of 3-<i>O</i>-Acetyl-11-Keto-Beta-Boswellic Acid from <i>Boswellia sacra</i> Resin on T-Cell Proliferation and Activation |
| title_full | Effects of 1<i>H</i>-1,2,3-Triazole Derivatives of 3-<i>O</i>-Acetyl-11-Keto-Beta-Boswellic Acid from <i>Boswellia sacra</i> Resin on T-Cell Proliferation and Activation |
| title_fullStr | Effects of 1<i>H</i>-1,2,3-Triazole Derivatives of 3-<i>O</i>-Acetyl-11-Keto-Beta-Boswellic Acid from <i>Boswellia sacra</i> Resin on T-Cell Proliferation and Activation |
| title_full_unstemmed | Effects of 1<i>H</i>-1,2,3-Triazole Derivatives of 3-<i>O</i>-Acetyl-11-Keto-Beta-Boswellic Acid from <i>Boswellia sacra</i> Resin on T-Cell Proliferation and Activation |
| title_short | Effects of 1<i>H</i>-1,2,3-Triazole Derivatives of 3-<i>O</i>-Acetyl-11-Keto-Beta-Boswellic Acid from <i>Boswellia sacra</i> Resin on T-Cell Proliferation and Activation |
| title_sort | effects of 1 i h i 1 2 3 triazole derivatives of 3 i o i acetyl 11 keto beta boswellic acid from i boswellia sacra i resin on t cell proliferation and activation |
| topic | boswellic acid T cells CD25 <i>β</i>-AKBA 1<i>H</i>-1,2,3-triazole |
| url | https://www.mdpi.com/1424-8247/17/12/1650 |
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