Nonpigmented Metastatic Melanoma in a Two-Year-Old Girl: A Serious Diagnostic Dilemma
Although rare, malignant melanoma may occur in children. Childhood melanomas account for only 0.3–3% of all melanomas. In particular the presence of congenital melanocytic nevi is associated with an increased risk of development of melanoma. We herein report a case of malignant melanoma that develop...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/298273 |
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| author | Gulden Diniz Hulya Tosun Yildirim Selcen Yamaci Nur Olgun |
| author_facet | Gulden Diniz Hulya Tosun Yildirim Selcen Yamaci Nur Olgun |
| author_sort | Gulden Diniz |
| collection | DOAJ |
| description | Although rare, malignant melanoma may occur in children. Childhood melanomas account for only 0.3–3% of all melanomas. In particular the presence of congenital melanocytic nevi is associated with an increased risk of development of melanoma. We herein report a case of malignant melanoma that developed on a giant congenital melanocytic nevus and made a metastasis to the subcutaneous tissue of neck in a two-year-old girl. The patient was hospitalized for differential diagnosis and treatment of cervical mass with a suspicion of hematological malignancy, because the malignant transformation of congenital nevus was not noticed before. In this case, we found out a nonpigmented malignant tumor of pleomorphic cells after the microscopic examination of subcutaneous lesion. Nonpigmented metastatic melanoma was diagnosed by several immunohistochemical and flow cytometric studies. She was offered palliative chemotherapy; however, her parents did not accept treatment. The patient died within 9 months of diagnosis. We emphasized here that the possibility of malignant melanoma in the differential diagnosis of childhood tumors should be kept in mind. |
| format | Article |
| id | doaj-art-4b5a8fef786e44f28f288fc4bddb8ea3 |
| institution | OA Journals |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-4b5a8fef786e44f28f288fc4bddb8ea32025-08-20T02:38:35ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/298273298273Nonpigmented Metastatic Melanoma in a Two-Year-Old Girl: A Serious Diagnostic DilemmaGulden Diniz0Hulya Tosun Yildirim1Selcen Yamaci2Nur Olgun3Izmir Tepecik Education and Research Hospital, Pathology Laboratory, TurkeyIzmir Dr. Behcet Uz Children’s Hospital, Pathology Laboratory and Dermatology Clinics, TurkeyIzmir Dr. Behcet Uz Children’s Hospital, Pathology Laboratory and Dermatology Clinics, TurkeyPediatric Oncology Clinics, Izmir Dokuz Eylul University, TurkeyAlthough rare, malignant melanoma may occur in children. Childhood melanomas account for only 0.3–3% of all melanomas. In particular the presence of congenital melanocytic nevi is associated with an increased risk of development of melanoma. We herein report a case of malignant melanoma that developed on a giant congenital melanocytic nevus and made a metastasis to the subcutaneous tissue of neck in a two-year-old girl. The patient was hospitalized for differential diagnosis and treatment of cervical mass with a suspicion of hematological malignancy, because the malignant transformation of congenital nevus was not noticed before. In this case, we found out a nonpigmented malignant tumor of pleomorphic cells after the microscopic examination of subcutaneous lesion. Nonpigmented metastatic melanoma was diagnosed by several immunohistochemical and flow cytometric studies. She was offered palliative chemotherapy; however, her parents did not accept treatment. The patient died within 9 months of diagnosis. We emphasized here that the possibility of malignant melanoma in the differential diagnosis of childhood tumors should be kept in mind.http://dx.doi.org/10.1155/2015/298273 |
| spellingShingle | Gulden Diniz Hulya Tosun Yildirim Selcen Yamaci Nur Olgun Nonpigmented Metastatic Melanoma in a Two-Year-Old Girl: A Serious Diagnostic Dilemma Case Reports in Oncological Medicine |
| title | Nonpigmented Metastatic Melanoma in a Two-Year-Old Girl: A Serious Diagnostic Dilemma |
| title_full | Nonpigmented Metastatic Melanoma in a Two-Year-Old Girl: A Serious Diagnostic Dilemma |
| title_fullStr | Nonpigmented Metastatic Melanoma in a Two-Year-Old Girl: A Serious Diagnostic Dilemma |
| title_full_unstemmed | Nonpigmented Metastatic Melanoma in a Two-Year-Old Girl: A Serious Diagnostic Dilemma |
| title_short | Nonpigmented Metastatic Melanoma in a Two-Year-Old Girl: A Serious Diagnostic Dilemma |
| title_sort | nonpigmented metastatic melanoma in a two year old girl a serious diagnostic dilemma |
| url | http://dx.doi.org/10.1155/2015/298273 |
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