Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation

Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation

Abstract The success of the poliovirus (PV) vaccines has enabled the near-eradication of wild PV, however, their continued use post-eradication poses concerns, due to the potential for virus escape during vaccine manufacture. Recombinant virus-like particles (VLPs) that lack the viral genome remove...

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Bibliographic Details
Main Authors: Lee Sherry, Keith Grehan, Mohammad W. Bahar, Jessica J. Swanson, Helen Fox, Sue Matthews, Sarah Carlyle, Ling Qin, Claudine Porta, Steven Wilkinson, Suzanne Robb, Naomi Clark, John Liddell, Elizabeth E. Fry, David I. Stuart, Andrew J. Macadam, David J. Rowlands, Nicola J. Stonehouse
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01111-2
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