Enhanced tumor suppression in patient-derived temozolomide-resistant glioblastoma cells using a combination treatment of Olaparib and FK866

Enhanced tumor suppression in patient-derived temozolomide-resistant glioblastoma cells using a combination treatment of Olaparib and FK866

Abstract Glioblastoma (GBM) is a prevalent brain cancer with notorious aggressiveness in adults. Standard treatment for GBM includes surgery, radiation, and administration of Temozolomide (TMZ). However, the TMZ resistance during chemotherapy poses a significant challenge. In the recent study a pati...

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Bibliographic Details
Main Authors: Xiaowei Sha, Jiaqian Li, Yunlong Fang, Jingjie Feng, Yasong Feng, Jing Wang, Yang Si, Feng Li, Shan Cheng, Wei Ding
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
GBM
TMZ
PARP inhibitor
NAMPT
Combination therapy
Online Access:https://doi.org/10.1186/s12885-025-14568-0
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