Comprehensive systematic review and meta-analysis on the therapeutic efficacy of curcumin in osteoporosis: unveiling mechanisms and preclinical evidence
BackgroundOsteoporosis (OP) is a common degenerative bone disease that seriously affects the quality of life of patients and poses a significant public health burden. Curcumin (CUR), a natural compound, has attracted much attention due to its anti-inflammatory, antioxidant and bone protective effect...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1590256/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850128423113981952 |
|---|---|
| author | Sheng-lei Yang Jing-xiang Wang Fei-er Ma Jiang-hua He Ao Zhang Xiao-ming Sun Ying Wei Yan Wang |
| author_facet | Sheng-lei Yang Jing-xiang Wang Fei-er Ma Jiang-hua He Ao Zhang Xiao-ming Sun Ying Wei Yan Wang |
| author_sort | Sheng-lei Yang |
| collection | DOAJ |
| description | BackgroundOsteoporosis (OP) is a common degenerative bone disease that seriously affects the quality of life of patients and poses a significant public health burden. Curcumin (CUR), a natural compound, has attracted much attention due to its anti-inflammatory, antioxidant and bone protective effects. However, there is currently a lack of systematic evaluation of the efficacy and mechanism of CUR in treating OP.MethodsThis study is a systematic review and meta-analysis conducted per PRISMA guidelines. Studies meeting the inclusion criteria were retrieved and screened from the PubMed, Embase, Web of Science, and Cochrane Library databases. The included studies were limited to animal models of OP, and the intervention group was treated with a single dose of CUR. A meta-analysis was performed using Review Manager 5.4 and R Studio software. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated using the fixed-effect or random-effects model. Sources of heterogeneity, sensitivity, and publication bias were also explored.ResultsA total of 17 high-quality studies involving 282 animals were included. The results of the metaanalysis showed that compared with the control group, CUR significantly increased bone mineral density (BMD of the femur: SMD = 2.18, 95% CI: 1.53–2.83; BMD of the tibia: SMD = 1.08, 95% CI: 0.30–1.87), improved the trabecular microstructure (BV/TV: SMD = 2.74, 95% CI: 1.84–3.64; Tb.N: SMD = 2.31, 95% CI: 1.65–2.96; Tb.Th: SMD = 2.09, 95% CI: 1.43–2.76; Tb.Sp: SMD = −2.32, 95% CI: −3.15 to −1.50). In addition, CUR significantly reduced serum CTX-1 and TRAP-5b levels, while increasing OCN and ALP levels. Mechanism studies have shown that CUR may act through OPG/RANKL, Wnt/β-catenin, NF-κB, MAPK, and TGF-β/Smad2/3 signaling pathways.ConclusionThis study is the first to systematically evaluate CUR's therapeutic effect on an OP animal model. The results show that CUR can significantly improve the pathological state of osteoporosis through a multi-target mechanism and has good therapeutic potential. However, heterogeneity and differences in the quality of the literature suggest that high-quality prospective studies are needed to verify the clinical value of CUR further. |
| format | Article |
| id | doaj-art-4b4fcae2c87d4e3da0760d8a2569adc4 |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-4b4fcae2c87d4e3da0760d8a2569adc42025-08-20T02:33:19ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-05-011210.3389/fnut.2025.15902561590256Comprehensive systematic review and meta-analysis on the therapeutic efficacy of curcumin in osteoporosis: unveiling mechanisms and preclinical evidenceSheng-lei Yang0Jing-xiang Wang1Fei-er Ma2Jiang-hua He3Ao Zhang4Xiao-ming Sun5Ying Wei6Yan Wang7School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaRehabilitation Medicine Center, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, ChinaSchool of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaSchool of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaDepartment of Rehabilition, West Coast New District Hospital of Chinese Medicine, Huangdao, Shandong, ChinaDepartment of Rehabilition, West Coast New District Hospital of Chinese Medicine, Huangdao, Shandong, ChinaRehabilitation Medicine Center, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, ChinaSchool of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaBackgroundOsteoporosis (OP) is a common degenerative bone disease that seriously affects the quality of life of patients and poses a significant public health burden. Curcumin (CUR), a natural compound, has attracted much attention due to its anti-inflammatory, antioxidant and bone protective effects. However, there is currently a lack of systematic evaluation of the efficacy and mechanism of CUR in treating OP.MethodsThis study is a systematic review and meta-analysis conducted per PRISMA guidelines. Studies meeting the inclusion criteria were retrieved and screened from the PubMed, Embase, Web of Science, and Cochrane Library databases. The included studies were limited to animal models of OP, and the intervention group was treated with a single dose of CUR. A meta-analysis was performed using Review Manager 5.4 and R Studio software. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated using the fixed-effect or random-effects model. Sources of heterogeneity, sensitivity, and publication bias were also explored.ResultsA total of 17 high-quality studies involving 282 animals were included. The results of the metaanalysis showed that compared with the control group, CUR significantly increased bone mineral density (BMD of the femur: SMD = 2.18, 95% CI: 1.53–2.83; BMD of the tibia: SMD = 1.08, 95% CI: 0.30–1.87), improved the trabecular microstructure (BV/TV: SMD = 2.74, 95% CI: 1.84–3.64; Tb.N: SMD = 2.31, 95% CI: 1.65–2.96; Tb.Th: SMD = 2.09, 95% CI: 1.43–2.76; Tb.Sp: SMD = −2.32, 95% CI: −3.15 to −1.50). In addition, CUR significantly reduced serum CTX-1 and TRAP-5b levels, while increasing OCN and ALP levels. Mechanism studies have shown that CUR may act through OPG/RANKL, Wnt/β-catenin, NF-κB, MAPK, and TGF-β/Smad2/3 signaling pathways.ConclusionThis study is the first to systematically evaluate CUR's therapeutic effect on an OP animal model. The results show that CUR can significantly improve the pathological state of osteoporosis through a multi-target mechanism and has good therapeutic potential. However, heterogeneity and differences in the quality of the literature suggest that high-quality prospective studies are needed to verify the clinical value of CUR further.https://www.frontiersin.org/articles/10.3389/fnut.2025.1590256/fullosteoporosiscurcuminanimal modelpreclinical studymeta-analysissystematic review |
| spellingShingle | Sheng-lei Yang Jing-xiang Wang Fei-er Ma Jiang-hua He Ao Zhang Xiao-ming Sun Ying Wei Yan Wang Comprehensive systematic review and meta-analysis on the therapeutic efficacy of curcumin in osteoporosis: unveiling mechanisms and preclinical evidence Frontiers in Nutrition osteoporosis curcumin animal model preclinical study meta-analysis systematic review |
| title | Comprehensive systematic review and meta-analysis on the therapeutic efficacy of curcumin in osteoporosis: unveiling mechanisms and preclinical evidence |
| title_full | Comprehensive systematic review and meta-analysis on the therapeutic efficacy of curcumin in osteoporosis: unveiling mechanisms and preclinical evidence |
| title_fullStr | Comprehensive systematic review and meta-analysis on the therapeutic efficacy of curcumin in osteoporosis: unveiling mechanisms and preclinical evidence |
| title_full_unstemmed | Comprehensive systematic review and meta-analysis on the therapeutic efficacy of curcumin in osteoporosis: unveiling mechanisms and preclinical evidence |
| title_short | Comprehensive systematic review and meta-analysis on the therapeutic efficacy of curcumin in osteoporosis: unveiling mechanisms and preclinical evidence |
| title_sort | comprehensive systematic review and meta analysis on the therapeutic efficacy of curcumin in osteoporosis unveiling mechanisms and preclinical evidence |
| topic | osteoporosis curcumin animal model preclinical study meta-analysis systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1590256/full |
| work_keys_str_mv | AT shengleiyang comprehensivesystematicreviewandmetaanalysisonthetherapeuticefficacyofcurcumininosteoporosisunveilingmechanismsandpreclinicalevidence AT jingxiangwang comprehensivesystematicreviewandmetaanalysisonthetherapeuticefficacyofcurcumininosteoporosisunveilingmechanismsandpreclinicalevidence AT feierma comprehensivesystematicreviewandmetaanalysisonthetherapeuticefficacyofcurcumininosteoporosisunveilingmechanismsandpreclinicalevidence AT jianghuahe comprehensivesystematicreviewandmetaanalysisonthetherapeuticefficacyofcurcumininosteoporosisunveilingmechanismsandpreclinicalevidence AT aozhang comprehensivesystematicreviewandmetaanalysisonthetherapeuticefficacyofcurcumininosteoporosisunveilingmechanismsandpreclinicalevidence AT xiaomingsun comprehensivesystematicreviewandmetaanalysisonthetherapeuticefficacyofcurcumininosteoporosisunveilingmechanismsandpreclinicalevidence AT yingwei comprehensivesystematicreviewandmetaanalysisonthetherapeuticefficacyofcurcumininosteoporosisunveilingmechanismsandpreclinicalevidence AT yanwang comprehensivesystematicreviewandmetaanalysisonthetherapeuticefficacyofcurcumininosteoporosisunveilingmechanismsandpreclinicalevidence |