The Rise of Mpox in a Post-Smallpox World
Reports of mpox are rising in Africa where the disease is endemic and in new countries where the disease has not been previously seen. The 2022 global outbreak of clade II mpox and an ongoing outbreak of the more lethal clade I mpox highlight the pandemic potential for monkeypox virus. Waning popul...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2025-01-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/31/1/24-1230_article |
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| author | Jennifer H. McQuiston Andrea McCollum Athalia Christie Fernando Torres Jonathan Mermin Daniel B. Jernigan Christina L. Hutson |
| author_facet | Jennifer H. McQuiston Andrea McCollum Athalia Christie Fernando Torres Jonathan Mermin Daniel B. Jernigan Christina L. Hutson |
| author_sort | Jennifer H. McQuiston |
| collection | DOAJ |
| description |
Reports of mpox are rising in Africa where the disease is endemic and in new countries where the disease has not been previously seen. The 2022 global outbreak of clade II mpox and an ongoing outbreak of the more lethal clade I mpox highlight the pandemic potential for monkeypox virus. Waning population immunity after the cessation of routine immunization for smallpox plays a key role in the changing epidemiologic patterns of mpox. Sustained human-to-human transmission of mpox is occurring widely in the context of insufficient population immunity, fueling genetic mutations that affect the accuracy of some diagnostic tests and that could lead to changing virulence. Additional research should address complex challenges for control of mpox, including improved diagnostics and medical countermeasures. The availability of vaccines should be expanded not only for outbreak response but also for broader routine use for persons in mpox-endemic countries.
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| format | Article |
| id | doaj-art-4b4c6c77e3064125accbc692f6d0ed2f |
| institution | OA Journals |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-4b4c6c77e3064125accbc692f6d0ed2f2025-08-20T01:59:52ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-01-01311273110.3201/eid3101.241230The Rise of Mpox in a Post-Smallpox WorldJennifer H. McQuistonAndrea McCollumAthalia ChristieFernando TorresJonathan MerminDaniel B. JerniganChristina L. Hutson Reports of mpox are rising in Africa where the disease is endemic and in new countries where the disease has not been previously seen. The 2022 global outbreak of clade II mpox and an ongoing outbreak of the more lethal clade I mpox highlight the pandemic potential for monkeypox virus. Waning population immunity after the cessation of routine immunization for smallpox plays a key role in the changing epidemiologic patterns of mpox. Sustained human-to-human transmission of mpox is occurring widely in the context of insufficient population immunity, fueling genetic mutations that affect the accuracy of some diagnostic tests and that could lead to changing virulence. Additional research should address complex challenges for control of mpox, including improved diagnostics and medical countermeasures. The availability of vaccines should be expanded not only for outbreak response but also for broader routine use for persons in mpox-endemic countries. https://wwwnc.cdc.gov/eid/article/31/1/24-1230_articlempoxmonkeypox virussmallpoxoutbreakorthopox vaccinevaccines |
| spellingShingle | Jennifer H. McQuiston Andrea McCollum Athalia Christie Fernando Torres Jonathan Mermin Daniel B. Jernigan Christina L. Hutson The Rise of Mpox in a Post-Smallpox World Emerging Infectious Diseases mpox monkeypox virus smallpox outbreak orthopox vaccine vaccines |
| title | The Rise of Mpox in a Post-Smallpox World |
| title_full | The Rise of Mpox in a Post-Smallpox World |
| title_fullStr | The Rise of Mpox in a Post-Smallpox World |
| title_full_unstemmed | The Rise of Mpox in a Post-Smallpox World |
| title_short | The Rise of Mpox in a Post-Smallpox World |
| title_sort | rise of mpox in a post smallpox world |
| topic | mpox monkeypox virus smallpox outbreak orthopox vaccine vaccines |
| url | https://wwwnc.cdc.gov/eid/article/31/1/24-1230_article |
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