Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha
Purpose. To compare the initial clinical features, laboratory values, and bone mineral density among patients with primary hyperparathyroidism (PHPT) in Changsha (China) and New Brunswick (USA). Methods. In this retrospective study, we reviewed 169 PHPT patients who presented at Robert Wood Johnson...
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| Format: | Article |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/6282687 |
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| author | Lingqiong Meng Shuying Liu Aseel Al-Dayyeni Zhifeng Sheng Zhiguang Zhou Xiangbing Wang |
| author_facet | Lingqiong Meng Shuying Liu Aseel Al-Dayyeni Zhifeng Sheng Zhiguang Zhou Xiangbing Wang |
| author_sort | Lingqiong Meng |
| collection | DOAJ |
| description | Purpose. To compare the initial clinical features, laboratory values, and bone mineral density among patients with primary hyperparathyroidism (PHPT) in Changsha (China) and New Brunswick (USA). Methods. In this retrospective study, we reviewed 169 PHPT patients who presented at Robert Wood Johnson University Hospital and 133 PHPT patients who presented at the Second Xiangya Hospital of Central South University in the same time period. The following characteristics were compared between the groups: age, gender, BMI, serum calcium, alkaline phosphatase (AKP), albumin, intact PTH (iPTH), 25-hydroxyvitamin D (25 (OH) D), fasting blood glucose levels, and bone mineral density (BMD). All these parameters were also compared according to gender and menopausal status. iPTH associations were also assessed along with several other parameters. Results. PHPT patients from Changsha had higher serum calcium, iPTH, and AKP levels but lower 25 (OH) D levels than the patients from New Brunswick (p<0.05). Patients in Changsha had lower T-scores and Z-scores in both the lumbar spine and hip regions than those in New Brunswick (p<0.05). Patients in New Brunswick had lower percentages of parathyroid adenoma and kidney stones. Serum iPTH level was positively correlated with serum calcium and serum AKP levels in both Changsha and New Brunswick (p<0.05). Conclusions. There are distinct biochemical and clinical differences between patients with PHPT in China and the United States. Our study revealed that Asian PHPT patients from Changsha presented more severe PHPT profiles, lower bone mineral density, and higher incidence of renal stones. |
| format | Article |
| id | doaj-art-4b42bbfe3139406d961e741ead25f02a |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-4b42bbfe3139406d961e741ead25f02a2025-02-03T05:58:07ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/62826876282687Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and ChangshaLingqiong Meng0Shuying Liu1Aseel Al-Dayyeni2Zhifeng Sheng3Zhiguang Zhou4Xiangbing Wang5Division of Endocrinology and Metabolism, Rutgers-RWJMS, New Brunswick, NJ 08901, USADepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaDivision of Endocrinology and Metabolism, Rutgers-RWJMS, New Brunswick, NJ 08901, USADepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaNational Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaDivision of Endocrinology and Metabolism, Rutgers-RWJMS, New Brunswick, NJ 08901, USAPurpose. To compare the initial clinical features, laboratory values, and bone mineral density among patients with primary hyperparathyroidism (PHPT) in Changsha (China) and New Brunswick (USA). Methods. In this retrospective study, we reviewed 169 PHPT patients who presented at Robert Wood Johnson University Hospital and 133 PHPT patients who presented at the Second Xiangya Hospital of Central South University in the same time period. The following characteristics were compared between the groups: age, gender, BMI, serum calcium, alkaline phosphatase (AKP), albumin, intact PTH (iPTH), 25-hydroxyvitamin D (25 (OH) D), fasting blood glucose levels, and bone mineral density (BMD). All these parameters were also compared according to gender and menopausal status. iPTH associations were also assessed along with several other parameters. Results. PHPT patients from Changsha had higher serum calcium, iPTH, and AKP levels but lower 25 (OH) D levels than the patients from New Brunswick (p<0.05). Patients in Changsha had lower T-scores and Z-scores in both the lumbar spine and hip regions than those in New Brunswick (p<0.05). Patients in New Brunswick had lower percentages of parathyroid adenoma and kidney stones. Serum iPTH level was positively correlated with serum calcium and serum AKP levels in both Changsha and New Brunswick (p<0.05). Conclusions. There are distinct biochemical and clinical differences between patients with PHPT in China and the United States. Our study revealed that Asian PHPT patients from Changsha presented more severe PHPT profiles, lower bone mineral density, and higher incidence of renal stones.http://dx.doi.org/10.1155/2018/6282687 |
| spellingShingle | Lingqiong Meng Shuying Liu Aseel Al-Dayyeni Zhifeng Sheng Zhiguang Zhou Xiangbing Wang Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha International Journal of Endocrinology |
| title | Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha |
| title_full | Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha |
| title_fullStr | Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha |
| title_full_unstemmed | Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha |
| title_short | Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha |
| title_sort | comparison of initial clinical presentations between primary hyperparathyroidism patients from new brunswick and changsha |
| url | http://dx.doi.org/10.1155/2018/6282687 |
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