Extracts and isolated compounds from the Acorus calamus L. (sweet flag) rhizome showed distinct antimetastatic activity against MDA-MB-231 breast cancer cells
The present work aims to investigate and validate the medicinal potential of Acorus calamus, a plant known for its high therapeutic potential. The focus was identifying biologically active extracts and compounds that exhibit promising anticancer properties. The cytotoxicity of the extracts and compo...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Maximum Academic Press
2024-01-01
|
| Series: | Medicinal Plant Biology |
| Subjects: | |
| Online Access: | https://www.maxapress.com/article/doi/10.48130/mpb-0024-0021 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850148319870844928 |
|---|---|
| author | Sabiyah Akhter Malik Muzafar Manzoor Sameer Ahmad Mir Tahirah Khaliq Phalisteen Sultan Qazi Parvaiz Hassan |
| author_facet | Sabiyah Akhter Malik Muzafar Manzoor Sameer Ahmad Mir Tahirah Khaliq Phalisteen Sultan Qazi Parvaiz Hassan |
| author_sort | Sabiyah Akhter |
| collection | DOAJ |
| description | The present work aims to investigate and validate the medicinal potential of Acorus calamus, a plant known for its high therapeutic potential. The focus was identifying biologically active extracts and compounds that exhibit promising anticancer properties. The cytotoxicity of the extracts and compounds extracted from the rhizomes of A. calamus was assessed in three different cancer cell lines: lung carcinoma (A549), colon carcinoma (HCT-116), and breast carcinoma (MDA-MB-231). The application of extracts derived from the rhizome of A. calamus significantly inhibited cell proliferation in various cancer cell lines, including lung, colon, and breast cancer cells. Furthermore, the isolated compounds ACS08 (stearic acid), ACS06 (beta-sitosterol), and ACS02 (β-asarone) exhibited superior anticancer activity against all the tested cancer cell lines, with an inhibition rate of ≥ 50%. Compared with ACS06 and ACS02, ACS08 exhibited greater cytotoxicity. Among the panel of cancer cell lines utilized, compound ACS08 exhibited greater efficacy against the MDA-MB-231 breast cancer cell line, as evidenced by an IC50 estimation of 55.89 μM. |
| format | Article |
| id | doaj-art-4b3f9bc33ece45fba6c331fa3cd16cc6 |
| institution | OA Journals |
| issn | 2835-6969 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Maximum Academic Press |
| record_format | Article |
| series | Medicinal Plant Biology |
| spelling | doaj-art-4b3f9bc33ece45fba6c331fa3cd16cc62025-08-20T02:27:18ZengMaximum Academic PressMedicinal Plant Biology2835-69692024-01-01311710.48130/mpb-0024-0021mpb-0024-0021Extracts and isolated compounds from the Acorus calamus L. (sweet flag) rhizome showed distinct antimetastatic activity against MDA-MB-231 breast cancer cellsSabiyah Akhter0Malik Muzafar Manzoor1Sameer Ahmad Mir2Tahirah Khaliq3Phalisteen Sultan4Qazi Parvaiz Hassan5Plant Molecular Biology and Biotechnology Division, CSIR Indian Institute of Integrative Medicine, Sanat Nagar-Srinagar 190005, Jammu and Kashmir, IndiaPlant Molecular Biology and Biotechnology Division, CSIR Indian Institute of Integrative Medicine, Sanat Nagar-Srinagar 190005, Jammu and Kashmir, IndiaCancer Pharmacology Division, CSIR Indian Institute of Integrative Medicine, Sanat Nagar-Srinagar 190005, Jammu and Kashmir, IndiaPlant Molecular Biology and Biotechnology Division, CSIR Indian Institute of Integrative Medicine, Sanat Nagar-Srinagar 190005, Jammu and Kashmir, IndiaPlant Molecular Biology and Biotechnology Division, CSIR Indian Institute of Integrative Medicine, Sanat Nagar-Srinagar 190005, Jammu and Kashmir, IndiaPlant Molecular Biology and Biotechnology Division, CSIR Indian Institute of Integrative Medicine, Sanat Nagar-Srinagar 190005, Jammu and Kashmir, IndiaThe present work aims to investigate and validate the medicinal potential of Acorus calamus, a plant known for its high therapeutic potential. The focus was identifying biologically active extracts and compounds that exhibit promising anticancer properties. The cytotoxicity of the extracts and compounds extracted from the rhizomes of A. calamus was assessed in three different cancer cell lines: lung carcinoma (A549), colon carcinoma (HCT-116), and breast carcinoma (MDA-MB-231). The application of extracts derived from the rhizome of A. calamus significantly inhibited cell proliferation in various cancer cell lines, including lung, colon, and breast cancer cells. Furthermore, the isolated compounds ACS08 (stearic acid), ACS06 (beta-sitosterol), and ACS02 (β-asarone) exhibited superior anticancer activity against all the tested cancer cell lines, with an inhibition rate of ≥ 50%. Compared with ACS06 and ACS02, ACS08 exhibited greater cytotoxicity. Among the panel of cancer cell lines utilized, compound ACS08 exhibited greater efficacy against the MDA-MB-231 breast cancer cell line, as evidenced by an IC50 estimation of 55.89 μM.https://www.maxapress.com/article/doi/10.48130/mpb-0024-0021acorus calamuscompoundsanticancermtt assaymda-mb-231 |
| spellingShingle | Sabiyah Akhter Malik Muzafar Manzoor Sameer Ahmad Mir Tahirah Khaliq Phalisteen Sultan Qazi Parvaiz Hassan Extracts and isolated compounds from the Acorus calamus L. (sweet flag) rhizome showed distinct antimetastatic activity against MDA-MB-231 breast cancer cells Medicinal Plant Biology acorus calamus compounds anticancer mtt assay mda-mb-231 |
| title | Extracts and isolated compounds from the Acorus calamus L. (sweet flag) rhizome showed distinct antimetastatic activity against MDA-MB-231 breast cancer cells |
| title_full | Extracts and isolated compounds from the Acorus calamus L. (sweet flag) rhizome showed distinct antimetastatic activity against MDA-MB-231 breast cancer cells |
| title_fullStr | Extracts and isolated compounds from the Acorus calamus L. (sweet flag) rhizome showed distinct antimetastatic activity against MDA-MB-231 breast cancer cells |
| title_full_unstemmed | Extracts and isolated compounds from the Acorus calamus L. (sweet flag) rhizome showed distinct antimetastatic activity against MDA-MB-231 breast cancer cells |
| title_short | Extracts and isolated compounds from the Acorus calamus L. (sweet flag) rhizome showed distinct antimetastatic activity against MDA-MB-231 breast cancer cells |
| title_sort | extracts and isolated compounds from the acorus calamus l sweet flag rhizome showed distinct antimetastatic activity against mda mb 231 breast cancer cells |
| topic | acorus calamus compounds anticancer mtt assay mda-mb-231 |
| url | https://www.maxapress.com/article/doi/10.48130/mpb-0024-0021 |
| work_keys_str_mv | AT sabiyahakhter extractsandisolatedcompoundsfromtheacoruscalamuslsweetflagrhizomeshoweddistinctantimetastaticactivityagainstmdamb231breastcancercells AT malikmuzafarmanzoor extractsandisolatedcompoundsfromtheacoruscalamuslsweetflagrhizomeshoweddistinctantimetastaticactivityagainstmdamb231breastcancercells AT sameerahmadmir extractsandisolatedcompoundsfromtheacoruscalamuslsweetflagrhizomeshoweddistinctantimetastaticactivityagainstmdamb231breastcancercells AT tahirahkhaliq extractsandisolatedcompoundsfromtheacoruscalamuslsweetflagrhizomeshoweddistinctantimetastaticactivityagainstmdamb231breastcancercells AT phalisteensultan extractsandisolatedcompoundsfromtheacoruscalamuslsweetflagrhizomeshoweddistinctantimetastaticactivityagainstmdamb231breastcancercells AT qaziparvaizhassan extractsandisolatedcompoundsfromtheacoruscalamuslsweetflagrhizomeshoweddistinctantimetastaticactivityagainstmdamb231breastcancercells |