Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases

Astrocytes are the most abundant and morphologically complex glial cells that play active roles in the central nervous system (CNS). Recent research has identified shared and region-specific astrocytic genes and functions, elucidated the cellular origins of their regional diversity, and uncovered th...

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Main Author: Fumito Endo
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Neuroscience Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S0168010224000981
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author Fumito Endo
author_facet Fumito Endo
author_sort Fumito Endo
collection DOAJ
description Astrocytes are the most abundant and morphologically complex glial cells that play active roles in the central nervous system (CNS). Recent research has identified shared and region-specific astrocytic genes and functions, elucidated the cellular origins of their regional diversity, and uncovered the molecular networks for astrocyte morphology, which are essential for their functional complexity. Reactive astrocytes exhibit a wide range of functional diversity in a context-specific manner in CNS disorders. This review discusses recent advances in understanding the molecular and morphological diversity of astrocytes in healthy individuals and those with neurodegenerative diseases, such as Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.
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spelling doaj-art-4b3ea006cc214a19ba0fcd68bfdf58f92025-01-16T04:28:16ZengElsevierNeuroscience Research0168-01022025-01-01210110Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseasesFumito Endo0Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, JapanAstrocytes are the most abundant and morphologically complex glial cells that play active roles in the central nervous system (CNS). Recent research has identified shared and region-specific astrocytic genes and functions, elucidated the cellular origins of their regional diversity, and uncovered the molecular networks for astrocyte morphology, which are essential for their functional complexity. Reactive astrocytes exhibit a wide range of functional diversity in a context-specific manner in CNS disorders. This review discusses recent advances in understanding the molecular and morphological diversity of astrocytes in healthy individuals and those with neurodegenerative diseases, such as Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.http://www.sciencedirect.com/science/article/pii/S0168010224000981Astrocyte diversityMorphological complexityAstrocyte reactivityAlzheimer's diseaseAmyotrophic lateral sclerosis
spellingShingle Fumito Endo
Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases
Neuroscience Research
Astrocyte diversity
Morphological complexity
Astrocyte reactivity
Alzheimer's disease
Amyotrophic lateral sclerosis
title Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases
title_full Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases
title_fullStr Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases
title_full_unstemmed Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases
title_short Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases
title_sort deciphering the spectrum of astrocyte diversity insights into molecular morphological and functional dimensions in health and neurodegenerative diseases
topic Astrocyte diversity
Morphological complexity
Astrocyte reactivity
Alzheimer's disease
Amyotrophic lateral sclerosis
url http://www.sciencedirect.com/science/article/pii/S0168010224000981
work_keys_str_mv AT fumitoendo decipheringthespectrumofastrocytediversityinsightsintomolecularmorphologicalandfunctionaldimensionsinhealthandneurodegenerativediseases