Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases
Astrocytes are the most abundant and morphologically complex glial cells that play active roles in the central nervous system (CNS). Recent research has identified shared and region-specific astrocytic genes and functions, elucidated the cellular origins of their regional diversity, and uncovered th...
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Elsevier
2025-01-01
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0168010224000981 |
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author | Fumito Endo |
author_facet | Fumito Endo |
author_sort | Fumito Endo |
collection | DOAJ |
description | Astrocytes are the most abundant and morphologically complex glial cells that play active roles in the central nervous system (CNS). Recent research has identified shared and region-specific astrocytic genes and functions, elucidated the cellular origins of their regional diversity, and uncovered the molecular networks for astrocyte morphology, which are essential for their functional complexity. Reactive astrocytes exhibit a wide range of functional diversity in a context-specific manner in CNS disorders. This review discusses recent advances in understanding the molecular and morphological diversity of astrocytes in healthy individuals and those with neurodegenerative diseases, such as Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. |
format | Article |
id | doaj-art-4b3ea006cc214a19ba0fcd68bfdf58f9 |
institution | Kabale University |
issn | 0168-0102 |
language | English |
publishDate | 2025-01-01 |
publisher | Elsevier |
record_format | Article |
series | Neuroscience Research |
spelling | doaj-art-4b3ea006cc214a19ba0fcd68bfdf58f92025-01-16T04:28:16ZengElsevierNeuroscience Research0168-01022025-01-01210110Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseasesFumito Endo0Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, JapanAstrocytes are the most abundant and morphologically complex glial cells that play active roles in the central nervous system (CNS). Recent research has identified shared and region-specific astrocytic genes and functions, elucidated the cellular origins of their regional diversity, and uncovered the molecular networks for astrocyte morphology, which are essential for their functional complexity. Reactive astrocytes exhibit a wide range of functional diversity in a context-specific manner in CNS disorders. This review discusses recent advances in understanding the molecular and morphological diversity of astrocytes in healthy individuals and those with neurodegenerative diseases, such as Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.http://www.sciencedirect.com/science/article/pii/S0168010224000981Astrocyte diversityMorphological complexityAstrocyte reactivityAlzheimer's diseaseAmyotrophic lateral sclerosis |
spellingShingle | Fumito Endo Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases Neuroscience Research Astrocyte diversity Morphological complexity Astrocyte reactivity Alzheimer's disease Amyotrophic lateral sclerosis |
title | Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases |
title_full | Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases |
title_fullStr | Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases |
title_full_unstemmed | Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases |
title_short | Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases |
title_sort | deciphering the spectrum of astrocyte diversity insights into molecular morphological and functional dimensions in health and neurodegenerative diseases |
topic | Astrocyte diversity Morphological complexity Astrocyte reactivity Alzheimer's disease Amyotrophic lateral sclerosis |
url | http://www.sciencedirect.com/science/article/pii/S0168010224000981 |
work_keys_str_mv | AT fumitoendo decipheringthespectrumofastrocytediversityinsightsintomolecularmorphologicalandfunctionaldimensionsinhealthandneurodegenerativediseases |