Chemical Composition, Antifungal, and Cytotoxicity Activities of Inga laurina (Sw.) Willd Leaves
The species Inga laurina is native to the Brazilian Cerrado. There are no studies about the chemical composition and biological activities of extracts of this endangered species. The ethanolic extract and its successive fractions are rich in phenolic compounds and presented good antifungal activitie...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2019/9423658 |
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| author | Carla de Moura Martins Sérgio A. L. de Morais Mário M. Martins Luís C. S. Cunha Cláudio V. da Silva Carlos H. G. Martins Luís F. Leandro Alberto de Oliveira Francisco J. T. de Aquino Evandro A. do Nascimento Roberto Chang |
| author_facet | Carla de Moura Martins Sérgio A. L. de Morais Mário M. Martins Luís C. S. Cunha Cláudio V. da Silva Carlos H. G. Martins Luís F. Leandro Alberto de Oliveira Francisco J. T. de Aquino Evandro A. do Nascimento Roberto Chang |
| author_sort | Carla de Moura Martins |
| collection | DOAJ |
| description | The species Inga laurina is native to the Brazilian Cerrado. There are no studies about the chemical composition and biological activities of extracts of this endangered species. The ethanolic extract and its successive fractions are rich in phenolic compounds and presented good antifungal activities. HPLC/MS-MS/MS and H1/C13 analysis led to the identification of seventeen compounds, most of which are gallic acid derivatives, myricetin and quercetin glycosides. The ethyl acetate fraction (EAF) contained high levels of total phenolics, expressed in milligrams of gallic acid equivalents per gram of extract (475.3 ± 1.9 mg GAE gextract-1) and flavonoids expressed in milligrams of quercetin equivalents per gram of extract (359.3 ± 10.6 mg QE gextract-1). This fraction was active against fungi of the Candida genus. The EAF showed MIC value 11.7 μg mL−1 against C. glabrata and a selectivity index of 1.6 against Vero cells. The flavonol glycoside myricetin-3-O-rhamnoside was isolated for the first time from the Inga laurina. These results make I. laurina a promising plant as a source of pharmaceutical and biological active antifungal compounds. |
| format | Article |
| id | doaj-art-4b39f2e27d924aa0a2464a5090510a34 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4b39f2e27d924aa0a2464a5090510a342025-02-03T05:51:51ZengWileyThe Scientific World Journal2356-61401537-744X2019-01-01201910.1155/2019/94236589423658Chemical Composition, Antifungal, and Cytotoxicity Activities of Inga laurina (Sw.) Willd LeavesCarla de Moura Martins0Sérgio A. L. de Morais1Mário M. Martins2Luís C. S. Cunha3Cláudio V. da Silva4Carlos H. G. Martins5Luís F. Leandro6Alberto de Oliveira7Francisco J. T. de Aquino8Evandro A. do Nascimento9Roberto Chang10Chemistry Nucleus, Goiano Federal Institute, Campus Morrinhos, BR-153, km 633, Rural Area, 75650-000 Morrinhos-GO, BrazilNatural Products Research Nucleus (NuPPeN), Federal University of Uberlândia, João Naves de Ávila Avenue, 2121, Santa Mônica, 38400-902 Uberlândia-MG, BrazilNatural Products Research Nucleus (NuPPeN), Federal University of Uberlândia, João Naves de Ávila Avenue, 2121, Santa Mônica, 38400-902 Uberlândia-MG, BrazilNatural Products Research Nucleus (NuPPeN), Federal University of Uberlândia, João Naves de Ávila Avenue, 2121, Santa Mônica, 38400-902 Uberlândia-MG, BrazilInstitute of Biomedical Sciences, Laboratory of Trypanosomatids, Federal University of Uberlândia, Pará Avenue, 1720, Umuarama, 38405-320 Uberlândia-MG, BrazilLaboratory of Research on Applied Microbiology, Franca University (UNIFRAN), Dr. Armando Salles Oliveira Avenue, 201, University Park, 14404-600 Franca-SP, BrazilLaboratory of Research on Applied Microbiology, Franca University (UNIFRAN), Dr. Armando Salles Oliveira Avenue, 201, University Park, 14404-600 Franca-SP, BrazilNatural Products Research Nucleus (NuPPeN), Federal University of Uberlândia, João Naves de Ávila Avenue, 2121, Santa Mônica, 38400-902 Uberlândia-MG, BrazilNatural Products Research Nucleus (NuPPeN), Federal University of Uberlândia, João Naves de Ávila Avenue, 2121, Santa Mônica, 38400-902 Uberlândia-MG, BrazilNatural Products Research Nucleus (NuPPeN), Federal University of Uberlândia, João Naves de Ávila Avenue, 2121, Santa Mônica, 38400-902 Uberlândia-MG, BrazilNatural Products Research Nucleus (NuPPeN), Federal University of Uberlândia, João Naves de Ávila Avenue, 2121, Santa Mônica, 38400-902 Uberlândia-MG, BrazilThe species Inga laurina is native to the Brazilian Cerrado. There are no studies about the chemical composition and biological activities of extracts of this endangered species. The ethanolic extract and its successive fractions are rich in phenolic compounds and presented good antifungal activities. HPLC/MS-MS/MS and H1/C13 analysis led to the identification of seventeen compounds, most of which are gallic acid derivatives, myricetin and quercetin glycosides. The ethyl acetate fraction (EAF) contained high levels of total phenolics, expressed in milligrams of gallic acid equivalents per gram of extract (475.3 ± 1.9 mg GAE gextract-1) and flavonoids expressed in milligrams of quercetin equivalents per gram of extract (359.3 ± 10.6 mg QE gextract-1). This fraction was active against fungi of the Candida genus. The EAF showed MIC value 11.7 μg mL−1 against C. glabrata and a selectivity index of 1.6 against Vero cells. The flavonol glycoside myricetin-3-O-rhamnoside was isolated for the first time from the Inga laurina. These results make I. laurina a promising plant as a source of pharmaceutical and biological active antifungal compounds.http://dx.doi.org/10.1155/2019/9423658 |
| spellingShingle | Carla de Moura Martins Sérgio A. L. de Morais Mário M. Martins Luís C. S. Cunha Cláudio V. da Silva Carlos H. G. Martins Luís F. Leandro Alberto de Oliveira Francisco J. T. de Aquino Evandro A. do Nascimento Roberto Chang Chemical Composition, Antifungal, and Cytotoxicity Activities of Inga laurina (Sw.) Willd Leaves The Scientific World Journal |
| title | Chemical Composition, Antifungal, and Cytotoxicity Activities of Inga laurina (Sw.) Willd Leaves |
| title_full | Chemical Composition, Antifungal, and Cytotoxicity Activities of Inga laurina (Sw.) Willd Leaves |
| title_fullStr | Chemical Composition, Antifungal, and Cytotoxicity Activities of Inga laurina (Sw.) Willd Leaves |
| title_full_unstemmed | Chemical Composition, Antifungal, and Cytotoxicity Activities of Inga laurina (Sw.) Willd Leaves |
| title_short | Chemical Composition, Antifungal, and Cytotoxicity Activities of Inga laurina (Sw.) Willd Leaves |
| title_sort | chemical composition antifungal and cytotoxicity activities of inga laurina sw willd leaves |
| url | http://dx.doi.org/10.1155/2019/9423658 |
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