Copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis
Background/Aim. Some oligoelements are now investigated as possibly having a role in atherosclerosis. The aim of this study was to compare the concentrations of copper and zinc in the serum and carotid plaque and parameters of lipid metabolism in patients with different morphology of car...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501400074T.pdf |
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| author | Tasić Nebojša M. Tasić Danijela Otašević Petar Veselinović Mirjana Jakovljević Vladimir Đurić Dragan Radak Đorđe |
| author_facet | Tasić Nebojša M. Tasić Danijela Otašević Petar Veselinović Mirjana Jakovljević Vladimir Đurić Dragan Radak Đorđe |
| author_sort | Tasić Nebojša M. |
| collection | DOAJ |
| description | Background/Aim. Some oligoelements are now investigated as possibly having a
role in atherosclerosis. The aim of this study was to compare the
concentrations of copper and zinc in the serum and carotid plaque and
parameters of lipid metabolism in patients with different morphology of
carotid atherosclerotic plaque. Methods. Carotid endarterectomy due to the
significant atherosclerotic stenosis was performed in 91 patients (mean age
64 ± 7). The control group consisted of 27 patients (mean age 58 ± 9),
without carotid atherosclerosis. Atheroscletoric plaques were divided into
four morphological groups, according to ultrasonic and intraoperative
characteristics. Copper and zinc concentrations in the plaque, carotid artery
and serum were measured by atomic absorption spectrophotometry. Results.
Serum copper concentrations were statistically significantly higher in the
patients with hemorrhagic in comparison to those with calcified plaque (1.2 ±
0.9 μmol/L vs 0.7 ± 0.2 μmol/L, respectively; p = 0.021). Zinc concentrations
were statistically significantly lower in plaques of the patients with
fibrolipid in comparison to those with calcified plaques (22.1 ± 16.3 μg/g vs
38.4 ± 25.8 μg/g, respectively; p = 0.024). A negative significant
correlation was found for zinc and triglycerides in the serum in all the
patients (r = -0.52, p = 0.025). In the control group we also demonstrated a
positive significant correlation for low-density lipoprotein cholesterol and
copper in the serum (r = 0.54, p = 0.04). Conclusion. The data obtained in
the current study are consistent with the hypothesis that high copper and
lower zinc levels may contribute to atherosclerosis and its sequelae as
factors in a multifactorial disease. Further studies are necessary in order
to conclude whether high concentration of copper and zinc in the serum could
be risk factors for atherosclesrosis. |
| format | Article |
| id | doaj-art-4b37261d720643549720c23e6aa331ef |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-4b37261d720643549720c23e6aa331ef2025-08-20T02:17:48ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202015-01-0172980180610.2298/VSP140417074T0042-84501400074TCopper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosisTasić Nebojša M.0Tasić Danijela1Otašević Petar2Veselinović Mirjana3Jakovljević Vladimir4Đurić Dragan5Radak Đorđe6Faculty of Medicine, Dedinje Cardiovascular Institute, BelgradeFaculty of Medicine, Dedinje Cardiovascular Institute, BelgradeFaculty of Medicine, Dedinje Cardiovascular Institute, BelgradeClinical Centre Kragujevac, Internal Medicine Clinic, Department of Rheumatology, KragujevacFaculty of Medicine, Department of Physiology, KragujevacFaculty of Medicine, Institute of Physiology “Richard Burian”, BelgradeFaculty of Medicine, Dedinje Cardiovascular Institute, BelgradeBackground/Aim. Some oligoelements are now investigated as possibly having a role in atherosclerosis. The aim of this study was to compare the concentrations of copper and zinc in the serum and carotid plaque and parameters of lipid metabolism in patients with different morphology of carotid atherosclerotic plaque. Methods. Carotid endarterectomy due to the significant atherosclerotic stenosis was performed in 91 patients (mean age 64 ± 7). The control group consisted of 27 patients (mean age 58 ± 9), without carotid atherosclerosis. Atheroscletoric plaques were divided into four morphological groups, according to ultrasonic and intraoperative characteristics. Copper and zinc concentrations in the plaque, carotid artery and serum were measured by atomic absorption spectrophotometry. Results. Serum copper concentrations were statistically significantly higher in the patients with hemorrhagic in comparison to those with calcified plaque (1.2 ± 0.9 μmol/L vs 0.7 ± 0.2 μmol/L, respectively; p = 0.021). Zinc concentrations were statistically significantly lower in plaques of the patients with fibrolipid in comparison to those with calcified plaques (22.1 ± 16.3 μg/g vs 38.4 ± 25.8 μg/g, respectively; p = 0.024). A negative significant correlation was found for zinc and triglycerides in the serum in all the patients (r = -0.52, p = 0.025). In the control group we also demonstrated a positive significant correlation for low-density lipoprotein cholesterol and copper in the serum (r = 0.54, p = 0.04). Conclusion. The data obtained in the current study are consistent with the hypothesis that high copper and lower zinc levels may contribute to atherosclerosis and its sequelae as factors in a multifactorial disease. Further studies are necessary in order to conclude whether high concentration of copper and zinc in the serum could be risk factors for atherosclesrosis.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501400074T.pdfzinccopperrisk factorsarteriosclerosiscarotid stenosislipids |
| spellingShingle | Tasić Nebojša M. Tasić Danijela Otašević Petar Veselinović Mirjana Jakovljević Vladimir Đurić Dragan Radak Đorđe Copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis Vojnosanitetski Pregled zinc copper risk factors arteriosclerosis carotid stenosis lipids |
| title | Copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis |
| title_full | Copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis |
| title_fullStr | Copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis |
| title_full_unstemmed | Copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis |
| title_short | Copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis |
| title_sort | copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis |
| topic | zinc copper risk factors arteriosclerosis carotid stenosis lipids |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501400074T.pdf |
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