Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity
Adipokines are bioactive molecules that regulate several physiological functions such as energy balance, insulin sensitization, appetite regulation, inflammatory response, and vascular homeostasis. They include proinflammatory cytokines such as adipocyte fatty acid binding protein (A-FABP) and anti-...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/8095926 |
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| author | Mostafa Wanees Ahmed El husseny Mediana Mamdouh Sara Shaban Abdelrahman Ibrahim Abushouk Marwa Mostafa Mohamed Zaki Osama M. Ahmed Mohamed M. Abdel-Daim |
| author_facet | Mostafa Wanees Ahmed El husseny Mediana Mamdouh Sara Shaban Abdelrahman Ibrahim Abushouk Marwa Mostafa Mohamed Zaki Osama M. Ahmed Mohamed M. Abdel-Daim |
| author_sort | Mostafa Wanees Ahmed El husseny |
| collection | DOAJ |
| description | Adipokines are bioactive molecules that regulate several physiological functions such as energy balance, insulin sensitization, appetite regulation, inflammatory response, and vascular homeostasis. They include proinflammatory cytokines such as adipocyte fatty acid binding protein (A-FABP) and anti-inflammatory cytokines such as adiponectin, as well as vasodilator and vasoconstrictor molecules. In obesity and type II diabetes mellitus (DM), insulin resistance causes impairment of the endocrine function of the perivascular adipose tissue, an imbalance in the secretion of vasoconstrictor and vasodilator molecules, and an increased production of reactive oxygen species. Recent studies have shown that targeting plasma levels of adipokines or the expression of their receptors can increase insulin sensitivity, improve vascular function, and reduce the risk of cardiovascular morbidity and mortality. Several reviews have discussed the potential of adipokines as therapeutic targets for type II DM and obesity; however, this review is the first to focus on their therapeutic potential for vascular dysfunction in type II DM and obesity. |
| format | Article |
| id | doaj-art-4b33554a523d4882bbb56e55619f7f48 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-4b33554a523d4882bbb56e55619f7f482025-08-20T03:36:27ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/80959268095926Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and ObesityMostafa Wanees Ahmed El husseny0Mediana Mamdouh1Sara Shaban2Abdelrahman Ibrahim Abushouk3Marwa Mostafa Mohamed Zaki4Osama M. Ahmed5Mohamed M. Abdel-Daim6Faculty of Medicine, Fayoum University, Fayoum, EgyptFaculty of Medicine, Fayoum University, Fayoum, EgyptFaculty of Medicine, Fayoum University, Fayoum, EgyptNovaMed Medical Research Association, Cairo, EgyptFaculty of Clinical Pharmacy, Fayoum University, Fayoum, EgyptPhysiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, EgyptPharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, EgyptAdipokines are bioactive molecules that regulate several physiological functions such as energy balance, insulin sensitization, appetite regulation, inflammatory response, and vascular homeostasis. They include proinflammatory cytokines such as adipocyte fatty acid binding protein (A-FABP) and anti-inflammatory cytokines such as adiponectin, as well as vasodilator and vasoconstrictor molecules. In obesity and type II diabetes mellitus (DM), insulin resistance causes impairment of the endocrine function of the perivascular adipose tissue, an imbalance in the secretion of vasoconstrictor and vasodilator molecules, and an increased production of reactive oxygen species. Recent studies have shown that targeting plasma levels of adipokines or the expression of their receptors can increase insulin sensitivity, improve vascular function, and reduce the risk of cardiovascular morbidity and mortality. Several reviews have discussed the potential of adipokines as therapeutic targets for type II DM and obesity; however, this review is the first to focus on their therapeutic potential for vascular dysfunction in type II DM and obesity.http://dx.doi.org/10.1155/2017/8095926 |
| spellingShingle | Mostafa Wanees Ahmed El husseny Mediana Mamdouh Sara Shaban Abdelrahman Ibrahim Abushouk Marwa Mostafa Mohamed Zaki Osama M. Ahmed Mohamed M. Abdel-Daim Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity Journal of Diabetes Research |
| title | Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity |
| title_full | Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity |
| title_fullStr | Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity |
| title_full_unstemmed | Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity |
| title_short | Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity |
| title_sort | adipokines potential therapeutic targets for vascular dysfunction in type ii diabetes mellitus and obesity |
| url | http://dx.doi.org/10.1155/2017/8095926 |
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