“Time to Change”: To What Extent Could Non-Sputum Sampling Accelerate the Fight Against Tuberculosis—A Qualitative Study Among End-Users

Inadequate access to timely diagnosis and linkage to treatment are major barriers to tuberculosis (TB) care. New point-of-care diagnostics that do not rely solely on sputum samples are needed to make up for lost time, bringing TB testing closer to service recipients and addressing current sputum sam...

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Main Authors: Vanessa Fargnoli, Hoang Thi My Hanh, Ly Na Hoang, Ananya Mahesh, Nasiphi Mqedlana-Ntombela, Jovitta Xavier, Mikashmi Kohli, Kavindhran Velen, Sonjelle Shilton
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Tropical Medicine and Infectious Disease
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Online Access:https://www.mdpi.com/2414-6366/10/2/44
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author Vanessa Fargnoli
Hoang Thi My Hanh
Ly Na Hoang
Ananya Mahesh
Nasiphi Mqedlana-Ntombela
Jovitta Xavier
Mikashmi Kohli
Kavindhran Velen
Sonjelle Shilton
author_facet Vanessa Fargnoli
Hoang Thi My Hanh
Ly Na Hoang
Ananya Mahesh
Nasiphi Mqedlana-Ntombela
Jovitta Xavier
Mikashmi Kohli
Kavindhran Velen
Sonjelle Shilton
author_sort Vanessa Fargnoli
collection DOAJ
description Inadequate access to timely diagnosis and linkage to treatment are major barriers to tuberculosis (TB) care. New point-of-care diagnostics that do not rely solely on sputum samples are needed to make up for lost time, bringing TB testing closer to service recipients and addressing current sputum sampling limitations. Urine-based TB lipoarabinomannan tests and tongue dorsum swabs have demonstrated potential as alternatives to sputum-based molecular testing. We conducted a study to ascertain the perceived value of these non-sputum-based TB tests among stakeholders from the TB community, including TB service recipients and healthcare providers, in India, South Africa, and Viet Nam. Our results showed that there was a high degree of enthusiasm among various end-users for both novel sample types. It is important to generate both qualitative and quantitative evidence to support optimal uptake and implementation of these potential new sample types for TB testing.
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publishDate 2025-02-01
publisher MDPI AG
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series Tropical Medicine and Infectious Disease
spelling doaj-art-4b2ebfbc7f654c26b8fe9d042d1eac012025-08-20T02:03:27ZengMDPI AGTropical Medicine and Infectious Disease2414-63662025-02-011024410.3390/tropicalmed10020044“Time to Change”: To What Extent Could Non-Sputum Sampling Accelerate the Fight Against Tuberculosis—A Qualitative Study Among End-UsersVanessa Fargnoli0Hoang Thi My Hanh1Ly Na Hoang2Ananya Mahesh3Nasiphi Mqedlana-Ntombela4Jovitta Xavier5Mikashmi Kohli6Kavindhran Velen7Sonjelle Shilton8FIND, 1218 Geneva, SwitzerlandHealth Strategy and Policy Institute (HSPI), Hanoi 100000, VietnamFIND, Hanoi 100000, VietnamResource group for Education and Advocacy for Community Health (REACH), Chennai 600014, IndiaThe Aurum Institute, Johannesburg 2194, South AfricaResource group for Education and Advocacy for Community Health (REACH), Chennai 600014, IndiaFIND, 1218 Geneva, SwitzerlandFIND, 1218 Geneva, SwitzerlandFIND, 1218 Geneva, SwitzerlandInadequate access to timely diagnosis and linkage to treatment are major barriers to tuberculosis (TB) care. New point-of-care diagnostics that do not rely solely on sputum samples are needed to make up for lost time, bringing TB testing closer to service recipients and addressing current sputum sampling limitations. Urine-based TB lipoarabinomannan tests and tongue dorsum swabs have demonstrated potential as alternatives to sputum-based molecular testing. We conducted a study to ascertain the perceived value of these non-sputum-based TB tests among stakeholders from the TB community, including TB service recipients and healthcare providers, in India, South Africa, and Viet Nam. Our results showed that there was a high degree of enthusiasm among various end-users for both novel sample types. It is important to generate both qualitative and quantitative evidence to support optimal uptake and implementation of these potential new sample types for TB testing.https://www.mdpi.com/2414-6366/10/2/44tuberculosisdiagnosisnon-sputum samplingurinetongue swabsend-users
spellingShingle Vanessa Fargnoli
Hoang Thi My Hanh
Ly Na Hoang
Ananya Mahesh
Nasiphi Mqedlana-Ntombela
Jovitta Xavier
Mikashmi Kohli
Kavindhran Velen
Sonjelle Shilton
“Time to Change”: To What Extent Could Non-Sputum Sampling Accelerate the Fight Against Tuberculosis—A Qualitative Study Among End-Users
Tropical Medicine and Infectious Disease
tuberculosis
diagnosis
non-sputum sampling
urine
tongue swabs
end-users
title “Time to Change”: To What Extent Could Non-Sputum Sampling Accelerate the Fight Against Tuberculosis—A Qualitative Study Among End-Users
title_full “Time to Change”: To What Extent Could Non-Sputum Sampling Accelerate the Fight Against Tuberculosis—A Qualitative Study Among End-Users
title_fullStr “Time to Change”: To What Extent Could Non-Sputum Sampling Accelerate the Fight Against Tuberculosis—A Qualitative Study Among End-Users
title_full_unstemmed “Time to Change”: To What Extent Could Non-Sputum Sampling Accelerate the Fight Against Tuberculosis—A Qualitative Study Among End-Users
title_short “Time to Change”: To What Extent Could Non-Sputum Sampling Accelerate the Fight Against Tuberculosis—A Qualitative Study Among End-Users
title_sort time to change to what extent could non sputum sampling accelerate the fight against tuberculosis a qualitative study among end users
topic tuberculosis
diagnosis
non-sputum sampling
urine
tongue swabs
end-users
url https://www.mdpi.com/2414-6366/10/2/44
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