TREATMENT OF EPILEPSY IN TUBEROUS SCLEROSIS
Epilepsy is the most frequent neurological sign of tuberous sclerosis complex (TSC) and it’s registered in 83.5% of patients. In majority of cases epilepsy begins during the first year of life (63%) and in 38.8% it’s manifesting as infantile spasms. The presence of epilepsy is closely connected with...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2016-08-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/232 |
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| author | E. D. Belousova M. Y. Dorofeeva T. G. Ohapkina |
| author_facet | E. D. Belousova M. Y. Dorofeeva T. G. Ohapkina |
| author_sort | E. D. Belousova |
| collection | DOAJ |
| description | Epilepsy is the most frequent neurological sign of tuberous sclerosis complex (TSC) and it’s registered in 83.5% of patients. In majority of cases epilepsy begins during the first year of life (63%) and in 38.8% it’s manifesting as infantile spasms. The presence of epilepsy is closely connected with development of mental retardation in TSC. Early treatment of epilepsy is a key to prevention of mental retardation, and preventive treatment with vigabatrin is now advised by some specialists. Possibly high efficasy of vigabatrin in treatment of seizures associated with TSC is partly due to its m-TOR inhibiting property. M-TOR way is widely discussed now as one of the perspective targets for epilepsy treatment, associated or not associated with TSC. |
| format | Article |
| id | doaj-art-4b2d211bf0d543baad5b4212abbd6c61 |
| institution | DOAJ |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| publishDate | 2016-08-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj-art-4b2d211bf0d543baad5b4212abbd6c612025-08-20T02:54:04ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882016-08-01823742231TREATMENT OF EPILEPSY IN TUBEROUS SCLEROSISE. D. Belousova0M. Y. Dorofeeva1T. G. Ohapkina2The Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian FederationThe Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian FederationThe Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian FederationEpilepsy is the most frequent neurological sign of tuberous sclerosis complex (TSC) and it’s registered in 83.5% of patients. In majority of cases epilepsy begins during the first year of life (63%) and in 38.8% it’s manifesting as infantile spasms. The presence of epilepsy is closely connected with development of mental retardation in TSC. Early treatment of epilepsy is a key to prevention of mental retardation, and preventive treatment with vigabatrin is now advised by some specialists. Possibly high efficasy of vigabatrin in treatment of seizures associated with TSC is partly due to its m-TOR inhibiting property. M-TOR way is widely discussed now as one of the perspective targets for epilepsy treatment, associated or not associated with TSC.https://www.epilepsia.su/jour/article/view/232tuberous sclerosis complextscepilepsytreatmentpreventive treatmentvigabatrinm-tor |
| spellingShingle | E. D. Belousova M. Y. Dorofeeva T. G. Ohapkina TREATMENT OF EPILEPSY IN TUBEROUS SCLEROSIS Эпилепсия и пароксизмальные состояния tuberous sclerosis complex tsc epilepsy treatment preventive treatment vigabatrin m-tor |
| title | TREATMENT OF EPILEPSY IN TUBEROUS SCLEROSIS |
| title_full | TREATMENT OF EPILEPSY IN TUBEROUS SCLEROSIS |
| title_fullStr | TREATMENT OF EPILEPSY IN TUBEROUS SCLEROSIS |
| title_full_unstemmed | TREATMENT OF EPILEPSY IN TUBEROUS SCLEROSIS |
| title_short | TREATMENT OF EPILEPSY IN TUBEROUS SCLEROSIS |
| title_sort | treatment of epilepsy in tuberous sclerosis |
| topic | tuberous sclerosis complex tsc epilepsy treatment preventive treatment vigabatrin m-tor |
| url | https://www.epilepsia.su/jour/article/view/232 |
| work_keys_str_mv | AT edbelousova treatmentofepilepsyintuberoussclerosis AT mydorofeeva treatmentofepilepsyintuberoussclerosis AT tgohapkina treatmentofepilepsyintuberoussclerosis |