The role of IL-17 family cytokines in cardiac fibrosis
Myocardial fibrosis is a common pathological feature in various cardiovascular diseases including myocardial infarction, heart failure, and myocarditis. Generally, persistent myocardial fibrosis correlates with poor prognosis and ranks among the leading causes of death globally. Currently, there is...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1470362/full |
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| author | Liqing Huang |
| author_facet | Liqing Huang |
| author_sort | Liqing Huang |
| collection | DOAJ |
| description | Myocardial fibrosis is a common pathological feature in various cardiovascular diseases including myocardial infarction, heart failure, and myocarditis. Generally, persistent myocardial fibrosis correlates with poor prognosis and ranks among the leading causes of death globally. Currently, there is no effective treatment for myocardial fibrosis, partly due to its unclear pathogenic mechanism. Increasing studies have shown IL-17 family cytokines are strongly associated with the initiation and propagation of myocardial fibrosis. This review summarizes the expression, action, and signal transduction mechanisms of IL-17, focusing on its role in fibrosis associated with cardiovascular diseases such as myocardial infarction, heart failure, hypertension, diabetes, and myocarditis. It also discusses its potential as a therapeutic target, offering new insights for the clinical treatment of myocardial fibrosis. |
| format | Article |
| id | doaj-art-4b2d0467fbf24cc891f8b34147c23c2c |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-4b2d0467fbf24cc891f8b34147c23c2c2025-08-20T02:08:46ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-10-011110.3389/fcvm.2024.14703621470362The role of IL-17 family cytokines in cardiac fibrosisLiqing HuangMyocardial fibrosis is a common pathological feature in various cardiovascular diseases including myocardial infarction, heart failure, and myocarditis. Generally, persistent myocardial fibrosis correlates with poor prognosis and ranks among the leading causes of death globally. Currently, there is no effective treatment for myocardial fibrosis, partly due to its unclear pathogenic mechanism. Increasing studies have shown IL-17 family cytokines are strongly associated with the initiation and propagation of myocardial fibrosis. This review summarizes the expression, action, and signal transduction mechanisms of IL-17, focusing on its role in fibrosis associated with cardiovascular diseases such as myocardial infarction, heart failure, hypertension, diabetes, and myocarditis. It also discusses its potential as a therapeutic target, offering new insights for the clinical treatment of myocardial fibrosis.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1470362/fullIL-17cardiac fibrosisfibroblastmyofibroblastextracellular matrix |
| spellingShingle | Liqing Huang The role of IL-17 family cytokines in cardiac fibrosis Frontiers in Cardiovascular Medicine IL-17 cardiac fibrosis fibroblast myofibroblast extracellular matrix |
| title | The role of IL-17 family cytokines in cardiac fibrosis |
| title_full | The role of IL-17 family cytokines in cardiac fibrosis |
| title_fullStr | The role of IL-17 family cytokines in cardiac fibrosis |
| title_full_unstemmed | The role of IL-17 family cytokines in cardiac fibrosis |
| title_short | The role of IL-17 family cytokines in cardiac fibrosis |
| title_sort | role of il 17 family cytokines in cardiac fibrosis |
| topic | IL-17 cardiac fibrosis fibroblast myofibroblast extracellular matrix |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1470362/full |
| work_keys_str_mv | AT liqinghuang theroleofil17familycytokinesincardiacfibrosis AT liqinghuang roleofil17familycytokinesincardiacfibrosis |