Microglia cannibalism during neurodevelopment results in necroptotic cell death.
Clearance of dying neurons by microglia is critical to healthy neurodevelopment, but what else do microglia eat? A new study in PLOS Biology demonstrates that microglia not only eat neurons but each other, and that this "microglia cannibalism" causes necroptotic cell death.
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-10-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002869 |
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| _version_ | 1850033555374080000 |
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| author | F Chris Bennett Mariko L Bennett |
| author_facet | F Chris Bennett Mariko L Bennett |
| author_sort | F Chris Bennett |
| collection | DOAJ |
| description | Clearance of dying neurons by microglia is critical to healthy neurodevelopment, but what else do microglia eat? A new study in PLOS Biology demonstrates that microglia not only eat neurons but each other, and that this "microglia cannibalism" causes necroptotic cell death. |
| format | Article |
| id | doaj-art-4b2b6c54089649a3bed94d0d2ea85bcc |
| institution | DOAJ |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-4b2b6c54089649a3bed94d0d2ea85bcc2025-08-20T02:58:10ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852024-10-012210e300286910.1371/journal.pbio.3002869Microglia cannibalism during neurodevelopment results in necroptotic cell death.F Chris BennettMariko L BennettClearance of dying neurons by microglia is critical to healthy neurodevelopment, but what else do microglia eat? A new study in PLOS Biology demonstrates that microglia not only eat neurons but each other, and that this "microglia cannibalism" causes necroptotic cell death.https://doi.org/10.1371/journal.pbio.3002869 |
| spellingShingle | F Chris Bennett Mariko L Bennett Microglia cannibalism during neurodevelopment results in necroptotic cell death. PLoS Biology |
| title | Microglia cannibalism during neurodevelopment results in necroptotic cell death. |
| title_full | Microglia cannibalism during neurodevelopment results in necroptotic cell death. |
| title_fullStr | Microglia cannibalism during neurodevelopment results in necroptotic cell death. |
| title_full_unstemmed | Microglia cannibalism during neurodevelopment results in necroptotic cell death. |
| title_short | Microglia cannibalism during neurodevelopment results in necroptotic cell death. |
| title_sort | microglia cannibalism during neurodevelopment results in necroptotic cell death |
| url | https://doi.org/10.1371/journal.pbio.3002869 |
| work_keys_str_mv | AT fchrisbennett microgliacannibalismduringneurodevelopmentresultsinnecroptoticcelldeath AT marikolbennett microgliacannibalismduringneurodevelopmentresultsinnecroptoticcelldeath |