Does patients' age predict their clinical outcomes following non-infectious epiglottitis? A systematic review.
<h4>Background</h4>Non-infectious epiglottitis, an infrequent but significant condition, presents challenges in airway management and treatment due to its potential for rapid progression.<h4>Objective</h4>To analyze differences in clinicodemographic characteristics, managemen...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0318648 |
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| author | Alaa Safia Uday Abd Elhadi Rabie Shehadeh Raed Farhat Majd Asakly Nidal El Khatib Ashraf Khater Taiser Bishara Saqr Massoud Shlomo Merchavy |
| author_facet | Alaa Safia Uday Abd Elhadi Rabie Shehadeh Raed Farhat Majd Asakly Nidal El Khatib Ashraf Khater Taiser Bishara Saqr Massoud Shlomo Merchavy |
| author_sort | Alaa Safia |
| collection | DOAJ |
| description | <h4>Background</h4>Non-infectious epiglottitis, an infrequent but significant condition, presents challenges in airway management and treatment due to its potential for rapid progression.<h4>Objective</h4>To analyze differences in clinicodemographic characteristics, management strategies, and clinical outcomes between pediatric and adult cases of non-infectious epiglottitis.<h4>Methods</h4>A systematic search of four databases identified 57 patient records, all diagnosed with non-infectious epiglottitis. Children (<18 years) were compared to adults (≥18 years). Differences in clinicodemographic characteristics, management strategies, and clinical outcomes were analyzed. Outcomes included intubation, complications, and intensive care unit (ICU) admission. Risk factors of these outcomes were identified through uni- and multi-variable logistic regression analyses.<h4>Results</h4>Twenty-three children and 34 adults were analyzed. The presentation with stridor (56.52% vs. 14.7%), drooling (56.52% vs. 26.47%), cyanosis (17.39% vs. 0%), and sternal retraction (13.04% vs. 0%) was more common among children. Prior vaccination was evident in only 5 pediatric cases. The etiology of epiglottitis was similar across groups. Children had significantly higher chances of receiving epinephrine (34.78% vs. 8.82%), undergoing intubation (82.60% vs. 20.58%), being admitted to the ICU (56.52% vs. 17.64%), and having complications (47.82% vs. 14.70%), compared to adults. In the multivariate regression model, pediatric age was a risk factor for intubation (p = 0.015) and ICU admission (p = 0.040), while foreign body ingestion (p = 0.039) and dyspnea (p = 0.014) were predictors of intubation and complications, respectively.<h4>Conclusions</h4>The study highlights the necessity for age-specific management strategies in non-infectious epiglottitis. Understanding the distinct clinical presentations and responses in different age groups can lead to improved patient care. |
| format | Article |
| id | doaj-art-4b27bef6bca74696bc97423fba88e6d4 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-4b27bef6bca74696bc97423fba88e6d42025-08-20T02:28:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e031864810.1371/journal.pone.0318648Does patients' age predict their clinical outcomes following non-infectious epiglottitis? A systematic review.Alaa SafiaUday Abd ElhadiRabie ShehadehRaed FarhatMajd AsaklyNidal El KhatibAshraf KhaterTaiser BisharaSaqr MassoudShlomo Merchavy<h4>Background</h4>Non-infectious epiglottitis, an infrequent but significant condition, presents challenges in airway management and treatment due to its potential for rapid progression.<h4>Objective</h4>To analyze differences in clinicodemographic characteristics, management strategies, and clinical outcomes between pediatric and adult cases of non-infectious epiglottitis.<h4>Methods</h4>A systematic search of four databases identified 57 patient records, all diagnosed with non-infectious epiglottitis. Children (<18 years) were compared to adults (≥18 years). Differences in clinicodemographic characteristics, management strategies, and clinical outcomes were analyzed. Outcomes included intubation, complications, and intensive care unit (ICU) admission. Risk factors of these outcomes were identified through uni- and multi-variable logistic regression analyses.<h4>Results</h4>Twenty-three children and 34 adults were analyzed. The presentation with stridor (56.52% vs. 14.7%), drooling (56.52% vs. 26.47%), cyanosis (17.39% vs. 0%), and sternal retraction (13.04% vs. 0%) was more common among children. Prior vaccination was evident in only 5 pediatric cases. The etiology of epiglottitis was similar across groups. Children had significantly higher chances of receiving epinephrine (34.78% vs. 8.82%), undergoing intubation (82.60% vs. 20.58%), being admitted to the ICU (56.52% vs. 17.64%), and having complications (47.82% vs. 14.70%), compared to adults. In the multivariate regression model, pediatric age was a risk factor for intubation (p = 0.015) and ICU admission (p = 0.040), while foreign body ingestion (p = 0.039) and dyspnea (p = 0.014) were predictors of intubation and complications, respectively.<h4>Conclusions</h4>The study highlights the necessity for age-specific management strategies in non-infectious epiglottitis. Understanding the distinct clinical presentations and responses in different age groups can lead to improved patient care.https://doi.org/10.1371/journal.pone.0318648 |
| spellingShingle | Alaa Safia Uday Abd Elhadi Rabie Shehadeh Raed Farhat Majd Asakly Nidal El Khatib Ashraf Khater Taiser Bishara Saqr Massoud Shlomo Merchavy Does patients' age predict their clinical outcomes following non-infectious epiglottitis? A systematic review. PLoS ONE |
| title | Does patients' age predict their clinical outcomes following non-infectious epiglottitis? A systematic review. |
| title_full | Does patients' age predict their clinical outcomes following non-infectious epiglottitis? A systematic review. |
| title_fullStr | Does patients' age predict their clinical outcomes following non-infectious epiglottitis? A systematic review. |
| title_full_unstemmed | Does patients' age predict their clinical outcomes following non-infectious epiglottitis? A systematic review. |
| title_short | Does patients' age predict their clinical outcomes following non-infectious epiglottitis? A systematic review. |
| title_sort | does patients age predict their clinical outcomes following non infectious epiglottitis a systematic review |
| url | https://doi.org/10.1371/journal.pone.0318648 |
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