Protective effect of fermented vegetable compounds against nonalcoholic fatty liver disease using metabolite profiling, integrated network pharmacology, and molecular docking approach
Vegetable fermentation extract (VFE) shows potential as a preventive agent to inhibit nonalcoholic fatty liver disease (NAFLD). This study identified bioactive compounds of VFE and explored the mechanism of VFE against NAFLD. Metabolite profiling was analysed using Liquid chromatography-tandem mass...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of Advanced Pharmaceutical Technology & Research |
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| Online Access: | https://journals.lww.com/10.4103/JAPTR.JAPTR_331_24 |
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| _version_ | 1850232846705229824 |
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| author | Ermin Rachmawati Larasati Sekar Kinasih Nabila Rahmadani Tias Pramesti Griana Roihatul Muti’ah Suharti Suharti Dwiki Pramudika Abdul Azis Endah Eni |
| author_facet | Ermin Rachmawati Larasati Sekar Kinasih Nabila Rahmadani Tias Pramesti Griana Roihatul Muti’ah Suharti Suharti Dwiki Pramudika Abdul Azis Endah Eni |
| author_sort | Ermin Rachmawati |
| collection | DOAJ |
| description | Vegetable fermentation extract (VFE) shows potential as a preventive agent to inhibit nonalcoholic fatty liver disease (NAFLD). This study identified bioactive compounds of VFE and explored the mechanism of VFE against NAFLD. Metabolite profiling was analysed using Liquid chromatography-tandem mass spectrometry (LC-MS/MS). The bioactive compounds were screened using the Lipinski Rule of 5, toxicity, and biological activity prediction, followed by network pharmacology and molecular docking. Of the 24 bioactive compounds identified, 8 compounds passed the screening process. Twenty-four genes from network pharmacology were involved in the NAFLD mechanism, including those related to insulin signaling, inflammation, and lipid metabolism. Kaempferol, apigenin, and N-(p-coumaroyl) serotonin showed a good binding affinity with CCR2, AKT, IL-6, and PPAR-γ compared to simvastatin and metformin. Bioactive compounds from VFE were predicted to ameliorate NAFLD. |
| format | Article |
| id | doaj-art-4b248753139a4d14b3600a73d697854c |
| institution | OA Journals |
| issn | 2231-4040 0976-2094 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Pharmaceutical Technology & Research |
| spelling | doaj-art-4b248753139a4d14b3600a73d697854c2025-08-20T02:03:04ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research2231-40400976-20942025-04-01162929810.4103/JAPTR.JAPTR_331_24Protective effect of fermented vegetable compounds against nonalcoholic fatty liver disease using metabolite profiling, integrated network pharmacology, and molecular docking approachErmin RachmawatiLarasati Sekar KinasihNabila RahmadaniTias Pramesti GrianaRoihatul Muti’ahSuharti SuhartiDwiki Pramudika Abdul AzisEndah EniVegetable fermentation extract (VFE) shows potential as a preventive agent to inhibit nonalcoholic fatty liver disease (NAFLD). This study identified bioactive compounds of VFE and explored the mechanism of VFE against NAFLD. Metabolite profiling was analysed using Liquid chromatography-tandem mass spectrometry (LC-MS/MS). The bioactive compounds were screened using the Lipinski Rule of 5, toxicity, and biological activity prediction, followed by network pharmacology and molecular docking. Of the 24 bioactive compounds identified, 8 compounds passed the screening process. Twenty-four genes from network pharmacology were involved in the NAFLD mechanism, including those related to insulin signaling, inflammation, and lipid metabolism. Kaempferol, apigenin, and N-(p-coumaroyl) serotonin showed a good binding affinity with CCR2, AKT, IL-6, and PPAR-γ compared to simvastatin and metformin. Bioactive compounds from VFE were predicted to ameliorate NAFLD.https://journals.lww.com/10.4103/JAPTR.JAPTR_331_24metabolite profilingmolecular dockingnetwork pharmacologynonalcoholic fatty liver diseasevegetable fermentation |
| spellingShingle | Ermin Rachmawati Larasati Sekar Kinasih Nabila Rahmadani Tias Pramesti Griana Roihatul Muti’ah Suharti Suharti Dwiki Pramudika Abdul Azis Endah Eni Protective effect of fermented vegetable compounds against nonalcoholic fatty liver disease using metabolite profiling, integrated network pharmacology, and molecular docking approach Journal of Advanced Pharmaceutical Technology & Research metabolite profiling molecular docking network pharmacology nonalcoholic fatty liver disease vegetable fermentation |
| title | Protective effect of fermented vegetable compounds against nonalcoholic fatty liver disease using metabolite profiling, integrated network pharmacology, and molecular docking approach |
| title_full | Protective effect of fermented vegetable compounds against nonalcoholic fatty liver disease using metabolite profiling, integrated network pharmacology, and molecular docking approach |
| title_fullStr | Protective effect of fermented vegetable compounds against nonalcoholic fatty liver disease using metabolite profiling, integrated network pharmacology, and molecular docking approach |
| title_full_unstemmed | Protective effect of fermented vegetable compounds against nonalcoholic fatty liver disease using metabolite profiling, integrated network pharmacology, and molecular docking approach |
| title_short | Protective effect of fermented vegetable compounds against nonalcoholic fatty liver disease using metabolite profiling, integrated network pharmacology, and molecular docking approach |
| title_sort | protective effect of fermented vegetable compounds against nonalcoholic fatty liver disease using metabolite profiling integrated network pharmacology and molecular docking approach |
| topic | metabolite profiling molecular docking network pharmacology nonalcoholic fatty liver disease vegetable fermentation |
| url | https://journals.lww.com/10.4103/JAPTR.JAPTR_331_24 |
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